Gene Page:SLC7A5

Summary?
GeneID 8140
Symbol SLC7A5
Synonyms 4F2LC|CD98|D16S469E|E16|LAT1|MPE16|hLAT1
Description solute carrier family 7 member 5
Reference MIM:600182|HGNC:HGNC:11063|Ensembl:ENSG00000103257|HPRD:02552|Vega:OTTHUMG00000137658
Gene type protein-coding
Map location 16q24.3
Pascal p-value 0.031
Sherlock p-value 0.302
DMG 2 (# studies)
eGene Myers' cis & trans
Support CELL METABOLISM

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Montano_2016 Genome-wide DNA methylation analysis This dataset includes 172 replicated associations between CpGs with schizophrenia. 4
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 4
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
SLC7A5 chr16 87885445 C G NM_003486 . silent Schizophrenia DNM:Fromer_2014

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg07558761 16 87866696 SLC7A5 1.32E-4 0.007 0.135 DMG:Montano_2016
cg07021906 16 87866833 SLC7A5 1.43E-4 0.008 0.139 DMG:Montano_2016
cg02203067 16 87866800 SLC7A5 1.47E-4 0.006 0.139 DMG:Montano_2016
cg08617020 16 87894491 SLC7A5 5.56E-4 0.36 0.049 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16827037 chr3 117203284 SLC7A5 8140 9.033E-4 trans
snp_a-4196049 0 SLC7A5 8140 0.13 trans
rs9369202 chr6 40390005 SLC7A5 8140 0.16 trans
rs10947885 chr6 40394397 SLC7A5 8140 0.03 trans
rs320082 chr7 29105404 SLC7A5 8140 2.863E-4 trans
rs317720 chr7 29110633 SLC7A5 8140 0.01 trans
rs317714 chr7 29115553 SLC7A5 8140 0.01 trans
rs317724 chr7 29120565 SLC7A5 8140 0.01 trans
rs11203077 chr10 91097084 SLC7A5 8140 0.17 trans
rs4414226 chr11 131236610 SLC7A5 8140 0.04 trans
rs11066476 chr12 113465366 SLC7A5 8140 0.08 trans
rs4497566 chr13 51694324 SLC7A5 8140 5.057E-4 trans
rs1307687 0 SLC7A5 8140 0 trans
rs12452652 chr17 72235560 SLC7A5 8140 0.15 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0015175 neutral amino acid transmembrane transporter activity TAS 9751058
GO:0015179 L-amino acid transmembrane transporter activity IEA -
GO:0042605 peptide antigen binding ISS -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007399 nervous system development IEA neurite (GO term level: 5) -
GO:0006520 amino acid metabolic process TAS 9751058
GO:0015807 L-amino acid transport IEA -
GO:0015804 neutral amino acid transport ISS -
GO:0006810 transport IEA -
GO:0006810 transport TAS 9751058
GO:0007275 multicellular organismal development IEA -
GO:0030154 cell differentiation IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm IEA -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane NAS 9751058
GO:0016324 apical plasma membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 91 65 All SZGR 2.0 genes in this pathway
REACTOME BASIGIN INTERACTIONS 30 23 All SZGR 2.0 genes in this pathway
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 31 21 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241 157 All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 94 65 All SZGR 2.0 genes in this pathway
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 49 36 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP 151 84 All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN 90 65 All SZGR 2.0 genes in this pathway
CORRE MULTIPLE MYELOMA UP 74 45 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290 177 All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP 158 103 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS RED UP 17 13 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP 78 41 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187 115 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536 332 All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA UP 141 75 All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP 181 101 All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN 87 49 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
PACHER TARGETS OF IGF1 AND IGF2 UP 35 27 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178 108 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS AND SERUM RESPONSE UP 47 32 All SZGR 2.0 genes in this pathway
WANG METHYLATED IN BREAST CANCER 35 25 All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE UP 57 41 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
TSUNODA CISPLATIN RESISTANCE DN 51 38 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
WILLIAMS ESR1 TARGETS UP 26 16 All SZGR 2.0 genes in this pathway
SCIAN INVERSED TARGETS OF TP53 AND TP73 DN 31 23 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382 224 All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283 177 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 16Q24 AMPLICON 53 38 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK 143 96 All SZGR 2.0 genes in this pathway
GOLDRATH HOMEOSTATIC PROLIFERATION 171 102 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309 206 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245 154 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION UP 87 67 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 VS CD2 UP 66 47 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT DN 129 86 All SZGR 2.0 genes in this pathway
GREENBAUM E2A TARGETS UP 33 18 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C8 72 56 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY TBH AND H2O2 36 24 All SZGR 2.0 genes in this pathway
HU GENOTOXIC DAMAGE 24HR 35 22 All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS 138 91 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
LEONARD HYPOXIA 47 35 All SZGR 2.0 genes in this pathway
RHODES UNDIFFERENTIATED CANCER 69 44 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156 101 All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 120 89 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 8 86 57 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR UP 101 69 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 141 92 All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN 49 34 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS 212 121 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
华莱士前列腺癌竞赛 299 167 All SZGR 2.0 genes in this pathway
YOKOE CANCER TESTIS ANTIGENS 38 22 All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS UP 48 31 All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354 216 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274 165 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN LUNG UP 21 10 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL A DN 18 7 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
GRATIAS RETINOBLASTOMA 16Q24 17 15 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294 199 All SZGR 2.0 genes in this pathway
FERRARI RESPONSE TO FENRETINIDE UP 22 16 All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 122 84 All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL UP 51 32 All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 67 52 All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS DN 142 79 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288 168 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237 159 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC UP 72 53 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 UP 87 50 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221 135 All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE DN 38 25 All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456 287 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567 365 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374 217 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229 149 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324 193 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-126/126-3p 164 170 1A hsa-miR-126brain UCGUACCGUGAGUAAUAAUGC