Gene Page:TRIM11

Summary?
GeneID 81559
Symbol TRIM11
Synonyms BIA1|RNF92
Description tripartite motif containing 11
Reference MIM:607868|HGNC:HGNC:16281|Ensembl:ENSG00000154370|HPRD:07429|Vega:OTTHUMG00000039773
Gene type protein-coding
Map location 1q42.13
Sherlock p-value 0.254
Fetal beta -0.271
DMG 1 (# studies)
eGene Cortex
Myers' cis & trans
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg17465697 1 228594029 TRIM11 1.8E-6 -0.343 0.008 DMG:Wockner_2014
cg07602073 1 228595680 TRIM17;TRIM11 7.2E-5 0.475 0.025 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16829545 chr2 151977407 TRIM11 81559 2.923 e-8 trans
rs7584986 chr2 184111432 TRIM11 81559 0.05 trans
rs16955618 chr15 29937543 TRIM11 81559 7.985E-12 trans
rs1041786 chr21 22617710 TRIM11 81559 0.04 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
某羊乳酪l (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AC023055.4 0.38 0.34
ACADVL 0.34 0.31
MOV10 0.34 0.32
PLD2 0.33 0.33
NPHP3 0.33 0.29
USP40 0.33 0.29
ATHL1 0.33 0.28
PDE6B 0.32 0.29
MYO15B 0.32 0.30
DNHD1 0.32 0.31
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FAM163B -0.27 -0.26
KCNF1 -0.26 -0.26
LNX1 -0.25 -0.27
HSPBP1 -0.25 -0.23
HS3ST2 -0.25 -0.25
CLTB -0.25 -0.25
AC073610.6 -0.24 -0.26
CDK5R2 -0.24 -0.23
C1QTNF4 -0.24 -0.22
MATK -0.23 -0.22

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251 156 All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212 129 All SZGR 2.0 genes in this pathway
CASTELLANO NRAS TARGETS UP 68 41 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE UP 86 57 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293 203 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway