Gene Page:C1orf21

Summary?
GeneID 81563
Symbol C1orf21
Synonyms PIG13
Description chromosome 1 open reading frame 21
Reference HGNC:HGNC:15494|Ensembl:ENSG00000116667|HPRD:12721|Vega:OTTHUMG00000035386
Gene type protein-coding
Map location 1q25
Sherlock p-value 0.744
Fetal beta -0.4
DMG 1 (# studies)
eGene Cortex

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg14509921 1 184357113 C1orf21 2.98E-10 -0.035 6.69E-7 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AL645608.4 0.80 0.76
CAPN10 0.79 0.78
B4GALNT4 0.79 0.78
LRRC45 0.79 0.73
TRABD 0.79 0.78
TAF1C 0.78 0.77
NINL 0.78 0.79
ANO8 0.78 0.80
SH3BP2 0.78 0.77
ZNF446 0.78 0.77
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PLA2G4A -0.57 -0.67
C5orf53 -0.55 -0.61
ABCG2 -0.54 -0.60
ITM2B -0.52 -0.57
CA4 -0.52 -0.58
B2M -0.52 -0.60
SLC39A8 -0.51 -0.54
AF347015.31 -0.50 -0.57
COPZ2 -0.49 -0.54
ANXA7 -0.49 -0.49

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 UP 112 72 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE DN 230 115 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380 213 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN UP 86 61 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL A UP 84 52 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307 182 All SZGR 2.0 genes in this pathway
国外RB1增长目标 243 155 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387 225 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway