Gene Page:TXNDC5

Summary?
GeneID 81567
Symbol TXNDC5
Synonyms ENDOPDI|ERP46|HCC-2|HCC2|PDIA15|STRF8|UNQ364
Description thioredoxin domain containing 5 (endoplasmic reticulum)
Reference MIM:616412|HGNC:HGNC:21073|Ensembl:ENSG00000239264|Ensembl:ENSG00000259040|HPRD:18249|Vega:OTTHUMG00000014216
Gene type protein-coding
Map location 6p24.3
Sherlock p-value 0.331
Fetal beta 0.449
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0159
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10515267 chr5 100128201 TXNDC5 81567 0.15 trans
rs11833888 chr12 59350152 TXNDC5 81567 0.17 trans
rs9548306 chr13 38876011 TXNDC5 81567 0.13 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0016853 isomerase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006916 anti-apoptosis TAS 16130169
GO:0045454 cell redox homeostasis IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005788 endoplasmic reticulum lumen IEA -
GO:0005783 endoplasmic reticulum TAS 16130169

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME MEMBRANE TRAFFICKING 129 74 All SZGR 2.0 genes in this pathway
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING 60 31 All SZGR 2.0 genes in this pathway
REACTOME LYSOSOME VESICLE BIOGENESIS 23 11 All SZGR 2.0 genes in this pathway
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 53 27 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING DN 90 57 All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN 85 56 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 105 67 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE 101 76 All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE 67 51 All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED DENDRITIC CELL 65 49 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 5 DN 50 31 All SZGR 2.0 genes in this pathway
TERAO AOX4 TARGETS HG UP 28 20 All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS DN 72 52 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-9 1068 1075 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA