Gene Page:PLA2G12A

Summary?
GeneID 81579
Symbol PLA2G12A
Synonyms GXII|PLA2G12|ROSSY
Description phospholipase A2 group XIIA
Reference MIM:611652|HGNC:HGNC:18554|Ensembl:ENSG00000123739|HPRD:17858|Vega:OTTHUMG00000131915
Gene type protein-coding
Map location 4q25
Pascal p-value 0.065
Fetal beta -0.011
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg05537210 4 110650914 PLA2G12A 3.939E-4 -0.192 0.043 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9749085 chr19 58142485 PLA2G12A 81579 0.19 trans
rs10409262 chr19 58154954 PLA2G12A 81579 0.08 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ZNF140 0.86 0.86
ZNF187 0.85 0.85
ZNF354A 0.85 0.84
UTP6 0.84 0.85
ZBED5 0.84 0.83
ZNF527 0.84 0.84
PGBD1 0.84 0.82
CEP78 0.84 0.83
ZNF568 0.84 0.83
CSTF3 0.84 0.84
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.67 -0.76
AF347015.27 -0.67 -0.76
AF347015.31 -0.66 -0.76
MT-CYB -0.66 -0.77
HLA-F -0.66 -0.70
FBXO2 -0.65 -0.69
HLA-C -0.64 -0.70
AIFM3 -0.64 -0.69
AF347015.8 -0.64 -0.76
AF347015.15 -0.63 -0.75

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLYCEROPHOSPHOLIPID METABOLISM 77 35 All SZGR 2.0 genes in this pathway
KEGG ETHER LIPID METABOLISM 33 15 All SZGR 2.0 genes in this pathway
KEGG ARACHIDONIC ACID METABOLISM 58 36 All SZGR 2.0 genes in this pathway
KEGG LINOLEIC ACID METABOLISM 29 16 All SZGR 2.0 genes in this pathway
KEGG ALPHA LINOLENIC ACID METABOLISM 19 9 All SZGR 2.0 genes in this pathway
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 76 53 All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY 79 58 All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 70 53 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
REACTOME ACYL CHAIN REMODELLING OF PI 15 8 All SZGR 2.0 genes in this pathway
REACTOME ACYL CHAIN REMODELLING OF PC 22 13 All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198 112 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PA 27 14 All SZGR 2.0 genes in this pathway
REACTOME ACYL CHAIN REMODELLING OF PG 16 8 All SZGR 2.0 genes in this pathway
REACTOME ACYL CHAIN REMODELLING OF PE 21 13 All SZGR 2.0 genes in this pathway
REACTOME ACYL CHAIN REMODELLING OF PS 15 7 All SZGR 2.0 genes in this pathway
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS 82 39 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380 215 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450 256 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316 190 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN 199 124 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176 111 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283 177 All SZGR 2.0 genes in this pathway
MORI MATURE B LYMPHOCYTE DN 75 43 All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK 169 111 All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS DN 57 39 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388 234 All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14 DELETION DN 60 38 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway