Gene Page:OR2B2
Summary?
| GeneID | 81697 |
| Symbol | OR2B2 |
| Synonyms | OR2B2Q|OR2B9|OR6-1|dJ193B12.4|hs6M1-10 |
| Description | olfactory receptor family 2 subfamily B member 2 |
| Reference | HGNC:HGNC:13966|Ensembl:ENSG00000168131|HPRD:17695|Vega:OTTHUMG00000014495 |
| Gene type | protein-coding |
| Map location | 6p22.3-p21.3 |
| Pascal p-value | 1E-12 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CCNI2 | 0.72 | 0.76 |
| SNCB | 0.71 | 0.72 |
| JDP2 | 0.70 | 0.73 |
| BNIP3 | 0.70 | 0.72 |
| SERPINI1 | 0.70 | 0.74 |
| VSNL1 | 0.70 | 0.73 |
| OSBPL1A | 0.70 | 0.73 |
| PRMT8 | 0.68 | 0.66 |
| CKMT1A | 0.68 | 0.74 |
| GNG3 | 0.67 | 0.69 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HYAL2 | -0.53 | -0.56 |
| SH2D2A | -0.47 | -0.53 |
| SH3BP2 | -0.46 | -0.50 |
| C21orf30 | -0.45 | -0.39 |
| VASH2 | -0.45 | -0.30 |
| KIAA1949 | -0.45 | -0.37 |
| TRAF4 | -0.45 | -0.49 |
| BCL7C | -0.45 | -0.56 |
| LRRC3 | -0.44 | -0.38 |
| NHSL1 | -0.44 | -0.43 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | IEA | - | |
| GO:0004984 | olfactory receptor activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | IEA | - | |
| GO:0007165 | signal transduction | IEA | - | |
| GO:0007608 | sensory perception of smell | IEA | - | |
| GO:0050896 | response to stimulus | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0005886 | plasma membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG嗅觉传导 | 389 | 85 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME OLFACTORY SIGNALING PATHWAY | 328 | 60 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| HUTTMANN B CLL POOR SURVIVAL UP | 276 | 187 | All SZGR 2.0 genes in this pathway |
| DURCHDEWALD SKIN CARCINOGENESIS DN | 264 | 168 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |