SZGR2 - Beplay体育中心

概括?

基因	826
Symbol	CAPNS1
Synonyms	CALPAIN4\|CANP\|CANPS\|CAPN4\|CDPS\|CSS1
Description	calpain small subunit 1
Reference	MIM:114170\|HGNC:HGNC:1481\|Ensembl:ENSG00000126247\|HPRD:00240\|Vega:OTTHUMG00000160811
Gene type	protein-coding
Map location	19q13.12
Pascal p-value	8.764E-4
Sherlock p-value	0.969
度p-value	度:Maycox_2009:CC_BA10_fold_change=-1.09:CC_BA10_disease_P=0.0323:HBB_BA9_fold_change=-1.19:HBB_BA9_disease_P=0.0420
Fetal beta	-1.19
DMG	1 (# studies)
eGene	Putamen basal ganglia Myers' cis & trans

数据源中的基因

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
度:Maycox_2009	Microarray to determine the expression of over 30000 mRNA transcripts in post-mortem tissue	We included 51 genes whose expression changes are common between two schizophrenia cohorts.
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	2

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg20717845	19	36630602	CAPNS1	1.48E-8	-0.008	5.66E-6	DMG:Jaffe_2016
cg19372504	19	36633213	CAPNS1	5.98E-8	0.018	1.51E-5	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs9966136	chr18	74881659	CAPNS1	826		0.12		trans
rs139322373	19	36823631	CAPNS1	ENSG00000126247.6	2.94415E-6	0.05	193154	gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
CHMP5	0.87	0.86
TXNDC9	0.87	0.85
TMEM49	0.86	0.88
COPS4	0.86	0.87
CCNC	0.85	0.84
OLA1	0.84	0.87
ACTR6	0.84	0.84
COMMD10	0.83	0.82
MRPS35	0.83	0.84
COPS2	0.82	0.87

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
GPT	-0.56	-0.63
MICALL2	-0.55	-0.64
FAM38A	-0.54	-0.57
TENC1	-0.53	-0.55
AF347015.26	-0.52	-0.53
C1orf175	-0.52	-0.60
SLC27A1	-0.52	-0.57
AC010618.2	-0.52	-0.58
DOCK6	-0.50	-0.52
PPP1R13L	-0.50	-0.50

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARR3	ARRX	arrestin 3, retinal (X-arrestin)	两个杂交	BioGRID	16169070
ATP5J2	ATP5JL	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2	两个杂交	BioGRID	16169070
C7orf20	CEE \| CGI-20	chromosome 7 open reading frame 20	两个杂交	BioGRID	16169070
CAPN1	CANP \| CANP1 \| CANPL1 \| muCANP \| muCL	calpain 1, (mu/I) large subunit	-	HPRD	12591934
CAPN1	CANP \| CANP1 \| CANPL1 \| muCANP \| muCL	calpain 1, (mu/I) large subunit	CAPN1 interacts with CAPNS1.	BIND	12358155
CAPN2	CANP2 \| CANPL2 \| CANPml \| FLJ39928 \| mCANP	calpain 2, (m/II) large subunit	-	HPRD,BioGRID	10639123\|10666632 \|11517928\|11673052
CAST	BS-17 \|MGC9402	calpastatin	-	HPRD	12684003
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	两个杂交	BioGRID	16169070
DRG1	DKFZp434N1827 \| NEDD3	developmentally regulated GTP binding protein 1	两个杂交	BioGRID	16169070
GNB2	-	guanine nucleotide binding protein (G protein), beta polypeptide 2	两个杂交	BioGRID	16169070
IL2RG	CD132 \| IMD4 \| SCIDX \| SCIDX1	interleukin 2 receptor, gamma (severe combined immunodeficiency)	-	HPRD,BioGRID	9326644
RAB1A	DKFZp564B163 \| RAB1 \| YPT1	RAB1A, member RAS oncogene family	两个杂交	BioGRID	16169070
TERF1	FLJ41416 \| PIN2 \| TRBF1 \| TRF \| TRF1 \| hTRF1-AS \| t-TRF1	telomeric repeat binding factor (NIMA-interacting) 1	两个杂交	BioGRID	16169070

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA P35ALZHEIMERS PATHWAY	11	9	该途径中的所有SZGR 2.0基因
BIOCARTA INTEGRIN PATHWAY	38	29	该途径中的所有SZGR 2.0基因
BIOCARTA MCALPAIN PATHWAY	25	16	该途径中的所有SZGR 2.0基因
BIOCARTA MEF2D PATHWAY	23	16	该途径中的所有SZGR 2.0基因
BIOCARTA UCALPAIN PATHWAY	18	11	该途径中的所有SZGR 2.0基因
GARY CD5 TARGETS UP	473	314	该途径中的所有SZGR 2.0基因
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	该途径中的所有SZGR 2.0基因
WANG ESOPHAGUS CANCER VS NORMAL DN	101	66	该途径中的所有SZGR 2.0基因
SANA TNF SIGNALING DN	90	57	该途径中的所有SZGR 2.0基因
PARK HSC VS MULTIPOTENT PROGENITORS UP	19	14	该途径中的所有SZGR 2.0基因
Zhan V2晚分化基因	45	34	该途径中的所有SZGR 2.0基因
WEIGEL OXIDATIVE STRESS RESPONSE	35	28	该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE DN	1237	837	该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 48HR DN	504	323	该途径中的所有SZGR 2.0基因
dazard对紫外线nhek的反应	244	151	该途径中的所有SZGR 2.0基因
DAZARD UV RESPONSE CLUSTER G4	21	15	该途径中的所有SZGR 2.0基因
KAAB HEART ATRIUM VS VENTRICLE DN	261	183	该途径中的所有SZGR 2.0基因
ZAMORA NOS2 TARGETS DN	96	71	该途径中的所有SZGR 2.0基因
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN	102	65	该途径中的所有SZGR 2.0基因
NUTT GBM VS AO GLIOMA UP	46	34	该途径中的所有SZGR 2.0基因
HOFMANN MYELODYSPLASTIC SYNDROM LOW RISK DN	30	20	该途径中的所有SZGR 2.0基因
HSIAO HOUSEKEEPING GENES	389	245	该途径中的所有SZGR 2.0基因
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 12	79	54	该途径中的所有SZGR 2.0基因
LI INDUCED T TO NATURAL KILLER UP	307	182	该途径中的所有SZGR 2.0基因
金所有障碍OLIGODENDROCYTE NUMBER CORR UP	756	494	该途径中的所有SZGR 2.0基因
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	该途径中的所有SZGR 2.0基因
FEVR CTNNB1 TARGETS UP	682	433	该途径中的所有SZGR 2.0基因
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	该途径中的所有SZGR 2.0基因
KOHOUTEK CCNT1 TARGETS	50	26	该途径中的所有SZGR 2.0基因
Delacroix Rarg Bound MEF	367	231	该途径中的所有SZGR 2.0基因
DELACROIX RAR BOUND ES	462	273	该途径中的所有SZGR 2.0基因

Gene Page:CAPNS1