Gene Page:CDC45
Summary?
| GeneID | 8318 |
| Symbol | CDC45 |
| Synonyms | CDC45L|CDC45L2|PORC-PI-1 |
| Description | cell division cycle 45 |
| Reference | MIM:603465|HGNC:HGNC:1739|Ensembl:ENSG00000093009|HPRD:09145|Vega:OTTHUMG00000150386 |
| Gene type | protein-coding |
| Map location | 22q11.21 |
| Pascal p-value | 0.014 |
| Fetal beta | 4.059 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CNV:YES | Copy number variation studies | Manual curation | |
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | 新闻学会 | 10518787 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0000076 | DNA replication checkpoint | TAS | 9660782 | |
| GO:0006270 | DNA replication initiation | TAS | 9660782 | |
| GO:0006260 | DNA replication | EXP | 12791985 | |
| GO:0006260 | DNA replication | IEA | - | |
| GO:0007049 | cell cycle | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005813 | centrosome | IDA | 18029348 | |
| GO:0005634 | nucleus | TAS | 9660782 | |
| GO:0005654 | nucleoplasm | EXP | 15226314|15707391 | |
| GO:0005737 | cytoplasm | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CELL CYCLE | 128 | 84 | 所有SZGR 2.0基因通路 |
| REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | 31 | 16 | 所有SZGR 2.0基因通路 |
| REACTOME CELL CYCLE | 421 | 253 | 所有SZGR 2.0基因通路 |
| REACTOME CELL CYCLE MITOTIC | 325 | 185 | 所有SZGR 2.0基因通路 |
| REACTOME CELL CYCLE CHECKPOINTS | 124 | 70 | 所有SZGR 2.0基因通路 |
| REACTOME M G1 TRANSITION | 81 | 45 | 所有SZGR 2.0基因通路 |
| REACTOME G1 S TRANSITION | 112 | 63 | 所有SZGR 2.0基因通路 |
| REACTOME SYNTHESIS OF DNA | 92 | 53 | 所有SZGR 2.0基因通路 |
| REACTOME MITOTIC G1 G1 S PHASES | 137 | 79 | 所有SZGR 2.0基因通路 |
| REACTOME MITOTIC M M G1 PHASES | 172 | 98 | 所有SZGR 2.0基因通路 |
| REACTOME DNA REPLICATION | 192 | 110 | 所有SZGR 2.0基因通路 |
| REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION | 35 | 17 | 所有SZGR 2.0基因通路 |
| REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | 38 | 18 | 所有SZGR 2.0基因通路 |
| REACTOME放松ING OF DNA | 11 | 6 | 所有SZGR 2.0基因通路 |
| REACTOME G1 S SPECIFIC TRANSCRIPTION | 19 | 9 | 所有SZGR 2.0基因通路 |
| REACTOME G2 M CHECKPOINTS | 45 | 23 | 所有SZGR 2.0基因通路 |
| REACTOME S PHASE | 109 | 66 | 所有SZGR 2.0基因通路 |
| REACTOME DNA STRAND ELONGATION | 30 | 18 | 所有SZGR 2.0基因通路 |
| SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP | 151 | 84 | 所有SZGR 2.0基因通路 |
| CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP | 146 | 86 | 所有SZGR 2.0基因通路 |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | 所有SZGR 2.0基因通路 |
| GAL LEUKEMIC STEM CELL DN | 244 | 153 | 所有SZGR 2.0基因通路 |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | 所有SZGR 2.0基因通路 |
| GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP | 181 | 101 | 所有SZGR 2.0基因通路 |
| GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN | 87 | 49 | 所有SZGR 2.0基因通路 |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | 所有SZGR 2.0基因通路 |
| LINDGREN BLADDER CANCER CLUSTER 1 DN | 378 | 231 | 所有SZGR 2.0基因通路 |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | 329 | 196 | 所有SZGR 2.0基因通路 |
| MARKEY RB1 ACUTE LOF DN | 228 | 137 | 所有SZGR 2.0基因通路 |
| BERENJENO通过RHOA转换 | 536 | 340 | 所有SZGR 2.0基因通路 |
| MISSIAGLIA REGULATED BY METHYLATION DN | 122 | 67 | 所有SZGR 2.0基因通路 |
| STREICHER LSM1 TARGETS UP | 44 | 34 | 所有SZGR 2.0基因通路 |
| PATIL LIVER CANCER | 747 | 453 | 所有SZGR 2.0基因通路 |
| AMUNDSON GENOTOXIC SIGNATURE | 105 | 68 | 所有SZGR 2.0基因通路 |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | 所有SZGR 2.0基因通路 |
| PUJANA BRCA2 PCC NETWORK | 423 | 265 | 所有SZGR 2.0基因通路 |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | 所有SZGR 2.0基因通路 |
| KAUFFMANN MELANOMA RELAPSE UP | 61 | 25 | 所有SZGR 2.0基因通路 |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | 所有SZGR 2.0基因通路 |
| BENPORATH NANOG TARGETS | 988 | 594 | 所有SZGR 2.0基因通路 |
| BENPORATH SOX2 TARGETS | 734 | 436 | 所有SZGR 2.0基因通路 |
| BENPORATH CYCLING GENES | 648 | 385 | 所有SZGR 2.0基因通路 |
| SUNG METASTASIS STROMA DN | 54 | 34 | 所有SZGR 2.0基因通路 |
| MORI IMMATURE B LYMPHOCYTE DN | 90 | 55 | 所有SZGR 2.0基因通路 |
| MORI MATURE B LYMPHOCYTE DN | 75 | 43 | 所有SZGR 2.0基因通路 |
| KAUFFMANN DNA REPLICATION GENES | 147 | 87 | 所有SZGR 2.0基因通路 |
| HESS TARGETS OF HOXA9 AND MEIS1 UP | 65 | 44 | 所有SZGR 2.0基因通路 |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | 所有SZGR 2.0基因通路 |
| BURTON ADIPOGENESIS 3 | 101 | 64 | 所有SZGR 2.0基因通路 |
| CUI TCF21 TARGETS 2 UP | 428 | 266 | 所有SZGR 2.0基因通路 |
| MARSON BOUND BY E2F4 UNSTIMULATED | 728 | 415 | 所有SZGR 2.0基因通路 |
| SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP | 180 | 114 | 所有SZGR 2.0基因通路 |
| MOLENAAR TARGETS OF CCND1 AND CDK4 DN | 58 | 25 | 所有SZGR 2.0基因通路 |
| SMID BREAST CANCER LUMINAL A DN | 18 | 7 | 所有SZGR 2.0基因通路 |
| SMID BREAST CANCER BASAL UP | 648 | 398 | 所有SZGR 2.0基因通路 |
| ZHENG GLIOBLASTOMA PLASTICITY UP | 250 | 168 | 所有SZGR 2.0基因通路 |
| WHITEFORD PEDIATRIC CANCER MARKERS | 116 | 63 | 所有SZGR 2.0基因通路 |
| GRADE COLON AND RECTAL CANCER UP | 285 | 167 | 所有SZGR 2.0基因通路 |
| BLUM RESPONSE TO SALIRASIB DN | 342 | 220 | 所有SZGR 2.0基因通路 |
| MUELLER PLURINET | 299 | 189 | 所有SZGR 2.0基因通路 |
| GOLDRATH ANTIGEN RESPONSE | 346 | 192 | 所有SZGR 2.0基因通路 |
| RUIZ TNC目标ETS DN | 142 | 79 | 所有SZGR 2.0基因通路 |
| HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP | 163 | 102 | 所有SZGR 2.0基因通路 |
| HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE DN | 50 | 36 | 所有SZGR 2.0基因通路 |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | 456 | 285 | 所有SZGR 2.0基因通路 |
| ZHANG TLX TARGETS 36HR DN | 185 | 116 | 所有SZGR 2.0基因通路 |
| ZHANG TLX TARGETS 60HR DN | 277 | 166 | 所有SZGR 2.0基因通路 |
| ZHANG TLX TARGETS DN | 89 | 50 | 所有SZGR 2.0基因通路 |
| CROONQUIST IL6 DEPRIVATION DN | 98 | 69 | 所有SZGR 2.0基因通路 |
| CROONQUIST NRAS VS STROMAL STIMULATION DN | 99 | 65 | 所有SZGR 2.0基因通路 |
| KOBAYASHI EGFR SIGNALING 24HR DN | 251 | 151 | 所有SZGR 2.0基因通路 |
| FOURNIER ACINAR DEVELOPMENT LATE 2 | 277 | 172 | 所有SZGR 2.0基因通路 |
| WINNEPENNINCKX MELANOMA METASTASIS UP | 162 | 86 | 所有SZGR 2.0基因通路 |
| WHITFIELD CELL CYCLE LITERATURE | 44 | 25 | 所有SZGR 2.0基因通路 |
| WHITFIELD CELL CYCLE S | 162 | 86 | 所有SZGR 2.0基因通路 |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN | 374 | 217 | 所有SZGR 2.0基因通路 |
| DUTERTRE ESTRADIOL RESPONSE 6HR UP | 229 | 149 | 所有SZGR 2.0基因通路 |
| DUTERTRE ESTRADIOL RESPONSE 24HR UP | 324 | 193 | 所有SZGR 2.0基因通路 |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | 所有SZGR 2.0基因通路 |
| LEE BMP2 TARGETS DN | 882 | 538 | 所有SZGR 2.0基因通路 |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | 所有SZGR 2.0基因通路 |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION UP | 570 | 339 | 所有SZGR 2.0基因通路 |
| PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 | 403 | 240 | 所有SZGR 2.0基因通路 |
| YU BAP1 TARGETS | 29 | 21 | 所有SZGR 2.0基因通路 |