Gene Page:HIST2H2AA3

Summary?
GeneID 8337
Symbol HIST2H2AA3
Synonyms H2A|H2A.2|H2A/O|H2A/q|H2AFO|H2a-615|HIST2H2AA
Description histone cluster 2, H2aa3
Reference MIM:142720|HGNC:HGNC:4736|Ensembl:ENSG00000203812|HPRD:08851|Vega:OTTHUMG00000188678
Gene type protein-coding
Map location 1q21.2
Sherlock p-value 0.71
DEG p-value DEG:Sanders_2014:DS1_p=-0.151:DS1_beta=0.026800:DS2_p=8.72e-06:DS2_beta=-0.211:DS2_FDR=6.23e-04
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
DEG:Sanders_2013 Microarray Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
GSMA_I Genome scan meta-analysis Psr: 0.0235
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00814

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2421519 chr1 170848473 HIST2H2AA3 8337 0.19 trans
rs7651293 chr3 140776297 HIST2H2AA3 8337 0.08 trans
rs10116858 chr9 20300988 HIST2H2AA3 8337 0.12 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
相约: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MICAL2 0.91 0.80
CAMK2A 0.90 0.86
C8orf46 0.89 0.84
CHN1 0.89 0.89
VSNL1 0.88 0.83
C1orf183 0.88 0.87
MFSD4 0.88 0.84
PACSIN1 0.88 0.82
VIPR1 0.87 0.84
AGBL4 0.87 0.80
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
BCL7C -0.56 -0.65
FADS2 -0.54 -0.51
TRAF4 -0.54 -0.61
SH2B2 -0.53 -0.61
SH3BP2 -0.52 -0.60
TUBB2B -0.52 -0.54
KIAA1949 -0.52 -0.45
SH2D2A -0.52 -0.57
SEMA4B -0.51 -0.50
PKN1 -0.51 -0.49

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006334 nucleosome assembly IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0000786 nucleosome IEA -
GO:0005634 nucleus IEA -
GO:0005694 chromosome IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS 140 100 All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS 116 81 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION 89 64 All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210 127 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION 122 80 All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE 122 80 All SZGR 2.0 genes in this pathway
REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 64 43 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I PROMOTER OPENING 62 49 All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC RECOMBINATION 86 62 All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC SYNAPSIS 73 57 All SZGR 2.0 genes in this pathway
REACTOME AMYLOIDS 83 63 All SZGR 2.0 genes in this pathway
REACTOME PACKAGING OF TELOMERE ENDS 48 40 All SZGR 2.0 genes in this pathway
REACTOME TELOMERE MAINTENANCE 75 57 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR DN 129 84 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
SANCHEZ MDM2 TARGETS 15 10 All SZGR 2.0 genes in this pathway
DACOSTA LOW DOSE UV RESPONSE VIA ERCC3 XPCS UP 18 10 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
GNATENKO PLATELET SIGNATURE 48 28 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION UP 38 25 All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO ESTRADIOL DN 82 52 All SZGR 2.0 genes in this pathway
REN BOUND BY E2F 61 40 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203 130 All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP 214 133 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
GENTILE UV LOW DOSE UP 27 19 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 120 89 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G4 21 15 All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312 203 All SZGR 2.0 genes in this pathway
GEORGANTAS HSC MARKERS 71 47 All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE UP 25 13 All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH UP 74 56 All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR UP 47 39 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON UP 77 47 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
CAMPS COLON CANCER COPY NUMBER DN 74 34 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
GRADE COLON VS RECTAL CANCER DN 56 36 All SZGR 2.0 genes in this pathway
CROONQUIST STROMAL STIMULATION UP 60 42 All SZGR 2.0 genes in this pathway
CROONQUIST NRAS VS STROMAL STIMULATION DN 99 65 All SZGR 2.0 genes in this pathway
KESHELAVA MULTIPLE DRUG RESISTANCE 88 56 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G24 28 19 All SZGR 2.0 genes in this pathway
DALESSIO TSA响应 29 16 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
CHEMELLO SOLEUS VS EDL MYOFIBERS UP 35 16 All SZGR 2.0 genes in this pathway