Gene Page:CASP1
Summary？
| GeneID | 834 |
| Symbol | CASP1 |
| Synonyms | ICE|IL1BC|P45 |
| Description | caspase 1 |
| Reference | MIM:147678|HGNC:HGNC:1499|Ensembl:ENSG00000137752|HPRD:00977|Vega：Otthumg0000000048072 |
| 基因类型 | 蛋白质编码 |
| Map location | 11q23 |
| Pascal p-value | 0.046 |
| DEG P值 | DEG：SANDERS_2014：DS1_P = 0.143：DS1_BETA = 0.049100：DS2_P = 4.63E-02：DS2_BETA = -0.097：DS2_FDR = 1.89E-01 |
| 胎儿β | -0.289 |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| DEG:Sanders_2013 | 微阵列 | 使用微阵列在413例和446例对照中使用微阵列（LCLS）上的微阵列进行全基因组基因表达谱。 | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.006 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 2.5585 |
Section I. Genetics and epigenetics annotation
第二节。转录组注释
一般基因表达（GTEX）
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。
No co-expressed genes in brain regions
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| 去：0005515 | 蛋白质结合 | IEA | - | |
| 去：0005515 | 蛋白质结合 | IPI | 12888622|15107016 | |
| 去：0004197 | 半胱氨酸型内肽酶活性 | IEA | - | |
| 去：0004197 | 半胱氨酸型内肽酶活性 | TAS | 10353249 | |
| GO:0008656 | caspase activator activity | TAS | 10799503 | |
| GO:0008233 | 肽酶活性 | IEA | - | |
| Biological process | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO:0001666 | 对缺氧的反应 | IEA | - | |
| 去：0006508 | proteolysis | IDA | 12888622 | |
| 去：0006508 | proteolysis | IEA | - | |
| GO:0008219 | cell death | IEA | - | |
| GO:0006917 | 诱导凋亡 | IEA | - | |
| GO:0007165 | 信号转导 | TAS | 1373520 | |
| GO：0042981 | 调节凋亡 | IEA | - | |
| GO：0016485 | protein processing | IEA | - | |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | IEP | 12761501 | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0005576 | 细胞外区域 | IEA | - | |
| 去：0005622 | 细胞内 | IEA | - | |
| 去：0005634 | nucleus | IDA | 18029348 | |
| 去：0005730 | nucleolus | IDA | 18029348 | |
| 去：0005737 | cytoplasm | IEA | - |
Section IV. Protein-protein interaction annotation
| 互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
|---|---|---|---|---|---|
| ar | AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM | 雄激素受体 | 雄激素受体与caspase 1相互作用。这种相互作用是基于未指定物种的人类雄激素受体和caspase 1的相互作用建模的。 | 绑定 | 9535906 |
| ATN1 | B37 | D12S755E | DRPLA | NOD | atrophin 1 | Atrophin-1与caspase 1相互作用。这种相互作用是建立在未指定物种中的人Atrophin-1和caspase 1之间的相互作用上建模的。 | 绑定 | 9535906 |
| atxn3 | AT3 | ATX3 | JOS | MJD | MJD1 | SCA3 | ataxin 3 | ataxin-3与caspase 1相互作用。这种相互作用是根据未指定物种的人ataxin-3和caspase 1之间的相互作用建模的。 | 绑定 | 9535906 |
| atxn3 | AT3 | ATX3 | JOS | MJD | MJD1 | SCA3 | ataxin 3 | - | HPRD | 9535906 |
| BCAP31 | 6c6-ag |BAP31 |CDM |DXS1357E | B细胞受体相关蛋白31 | - | HPRD,BioGRID | 9334338 |
| CARD16 | 警察|警察1 | PSEUDO-ICE | caspase招聘域家庭，成员16 | - | HPRD | 11432859|11536016 |
| CARD17 | 印加 | caspase招聘域家庭，成员17 | - | HPRD | 15383541 |
| 卡8 | 红衣主教|达卡|DKFZP779L0366 |达喀尔|FLJ18119 |FLJ18121 |KIAA0955 |MGC57162 |NDPP |NDPP1 | TUCAN | caspase recruitment domain family, member 8 | - | HPRD | 11821383 |
| 卡8 | 红衣主教|达卡|DKFZP779L0366 |达喀尔|FLJ18119 |FLJ18121 |KIAA0955 |MGC57162 |NDPP |NDPP1 | TUCAN | caspase recruitment domain family, member 8 | CARD-8 interacts with Casp-1 | 绑定 | 11821383 |
| CASP1 | ICE | IL1BC | P45 | caspase 1，与凋亡相关的半胱氨酸肽酶（白介素1，β，转化酶） | - | HPRD | 9190289 |
| CASP1 | ICE | IL1BC | P45 | caspase 1，与凋亡相关的半胱氨酸肽酶（白介素1，β，转化酶） | 亲和力捕获 - 韦斯特恩 | Biogrid | 11432859 |
| CASP10 | ALPS2 | FLICE2 | MCH4 | caspase 10，与凋亡相关的半胱氨酸肽酶 | 生化活动 | Biogrid | 8962078 |
| CASP14 | MGC119078 |MGC119079 | caspase 14, apoptosis-related cysteine peptidase | - | HPRD,BioGRID | 9792675 |
| CASP4 | ICE(rel)II | ICEREL-II | ICH-2 | Mih1/TX | TX | caspase 4，与凋亡相关的半胱氨酸肽酶 | 重构的复合物 | Biogrid | 10477277 |
| CASP8 | ALPS2B |cap4 |弗里斯|FLJ17672 |马赫|MCH5 |MGC78473 | caspase 8, apoptosis-related cysteine peptidase | 生化活动 | Biogrid | 8962078 |
| 警察 | 克尔托 | 网格蛋白排序的蛋白质 | 亲和力捕获 - 韦斯特恩 | Biogrid | 11432859 |
| egfr | ERBB |ERBB1 |her1 |PIG61 |梅纳 | 表皮生长因子受体（红细胞性白血病病毒（V-ERB-B）癌基因同源物，鸟类） | - | HPRD,BioGRID | 11226410 |
| htt | 高清|IT15 | huntingtin | Huntingtin interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human huntingtin and caspase 1 from an unspecified species. | 绑定 | 9535906 |
| htt | 高清|IT15 | huntingtin | - | HPRD | 9535906 |
| IL18 | IGIF | IL-18 | IL-1g | IL1F4 | MGC12320 | interleukin 18 (interferon-gamma-inducing factor) | 生化活动 | Biogrid | 12096920 |
| IL1F7 | FIL1 | FIL1(ZETA) | FIL1Z | IL-1F7 | IL-1H4 | IL-1RP1 | IL1H4 | IL1RP1 | interleukin 1 family, member 7 (zeta) | 生化活动 | Biogrid | 12096920 |
| NA | NAC | neurocanthocytosis | 亲和力捕获 - 韦斯特恩 | Biogrid | 15107016 |
| NFE2L2 | NRF2 | nuclear factor (erythroid-derived 2)-like 2 | - | HPRD,BioGRID | 10510468 |
| NLRC4 | CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAF | NLR family, CARD domain containing 4 | - | HPRD,BioGRID | 11472070 |
| NLRC4 | CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAF | NLR family, CARD domain containing 4 | Card12（氏族）与CASP1相互作用。这种相互作用是基于未指定物种的人类Card12和Casp1之间的相互作用进行建模的。 | 绑定 | 15107016 |
| NLRC4 | CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAF | NLR family, CARD domain containing 4 | - | HPRD | 11390368|11472070 | 11472070 |
| NLRP1 | CARD7 | CLR17.1 | DEFCAP | DEFCAP-L/S | DKFZp586O1822 | KIAA0926 | NAC | NALP1 | PP1044 | SLEV1 | VAMAS1 | NLR家族，含有1个 | NALP1 (NAC) interacts with CASP1. This interaction was modelled on a demonstrated interaction between human NALP1 and CASP1 from an unspecified species. | 绑定 | 15107016 |
| NOD1 | card4 |Clr7.1 |NLRC1 | nucleotide-binding寡聚化域containing 1 | - | HPRD,BioGRID | 10329646 |
| NOD2 | ACUG | BLAU | CARD15 | CD | CLR16.3 | IBD1 | NLRC2 | NOD2B | PSORAS1 | 包含2的核苷酸结合寡聚结构域 | 亲和力捕获 - 韦斯特恩 | Biogrid | 15107016 |
| NOD2 | ACUG | BLAU | CARD15 | CD | CLR16.3 | IBD1 | NLRC2 | NOD2B | PSORAS1 | 包含2的核苷酸结合寡聚结构域 | Card15（NOD2）与CASP1相互作用。这种相互作用是基于未指定物种的人类Card15和Casp1之间的相互作用进行建模的。 | 绑定 | 15107016 |
| park2 | ar-JP | LPRS2 | PDJ | PRKN | 帕金森病（常染色体隐性，少年）2，帕金 | - | HPRD | 12692130 |
| PSEN1 | AD3 | FAD | PS1 | S182 | Presenilin 1 | PS-1 interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 1. | 绑定 | 10069390 |
| Pycard | ASC | CARD5 | MGC10332 | TMS | TMS-1 | TMS1 | PYD和卡域包含 | - | HPRD | 11967258|12019269 |12191486 |
| RIPK2 | CARD3 | CARDIAK | CCK | GIG30 | RICK | RIP2 | 受体相互作用丝氨酸 - 硫代激酶2 | - | HPRD,BioGRID | 9705938 |