Gene Page:HIST1H2BC

Summary?
基因 8347
Symbol HIST1H2BC
Synonyms H2B.1|H2B/l|H2BFL|dJ221C16.3
Description histone cluster 1, H2bc
Reference MIM:602847|HGNC:HGNC:4757|HPRD:13656|
Gene type protein-coding
Map location 6p22.1
Pascal p-value 1E-12
DEG p-value DEG:Sanders_2014:DS1_p=-0.148:DS1_beta=0.034000:DS2_p=1.75e-04:DS2_beta=-0.185:DS2_FDR=5.55e-03
Fetal beta 0.855

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DEG:Sanders_2013 Microarray Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
PMID:cooccur High-throughput literature-search 系统搜索PubMed的基因co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.033
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MARCH5 0.94 0.95
GPN1 0.93 0.94
DLSTP 0.93 0.93
KBTBD4 0.92 0.93
CAPRIN1 0.92 0.94
LSG1 0.92 0.94
MTMR1 0.92 0.92
MKRN1 0.92 0.92
CSNK2A1 0.92 0.94
PSMD11 0.92 0.94
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.81 -0.88
MT-CO2 -0.81 -0.89
AF347015.27 -0.80 -0.89
AF347015.8 -0.79 -0.89
AF347015.33 -0.78 -0.86
MT-CYB -0.78 -0.87
AF347015.21 -0.76 -0.88
AF347015.15 -0.76 -0.87
AF347015.2 -0.74 -0.86
FXYD1 -0.73 -0.84

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding NAS 422550|9119399
GO:0005515 protein binding 新闻学会 17353931
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006334 nucleosome assembly NAS 422550|9119399
GO:0042742 defense response to bacterium IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0000786 nucleosome NAS 422550|9119399
GO:0005634 nucleus IEA -
GO:0005694 chromosome IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS 140 100 All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS 116 81 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I TRANSCRIPTION 89 64 All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210 127 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION 122 80 All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE 122 80 All SZGR 2.0 genes in this pathway
REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE 64 43 All SZGR 2.0 genes in this pathway
REACTOME RNA POL I PROMOTER OPENING 62 49 All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC RECOMBINATION 86 62 All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC SYNAPSIS 73 57 All SZGR 2.0 genes in this pathway
REACTOME AMYLOIDS 83 63 All SZGR 2.0 genes in this pathway
REACTOME PACKAGING OF TELOMERE ENDS 48 40 All SZGR 2.0 genes in this pathway
REACTOME TELOMERE MAINTENANCE 75 57 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 384 All SZGR 2.0 genes in this pathway
KIM RESPONSE TO TSA AND DECITABINE UP 129 73 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 142 95 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153 100 All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF DN 118 78 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215 137 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY DN 110 64 All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER C 113 47 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION UP 140 83 All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 126 90 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183 111 All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP 214 133 All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS 66 48 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
HU GENOTOXIN ACTION DIRECT VS INDIRECT 24HR 55 38 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 5 126 78 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215 132 All SZGR 2.0 genes in this pathway
GEORGANTAS HSC MARKERS 71 47 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
Heller HDAC靶向被甲基化的沉默 461 298 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 DN 228 114 All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299 189 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP 221 150 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293 203 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS UP 108 78 All SZGR 2.0 genes in this pathway
ELLWOOD MYC TARGETS DN 40 27 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 12 79 54 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S 162 86 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
BOUDOUKHA BOUND BY IGF2BP2 111 59 All SZGR 2.0 genes in this pathway