Gene Page:CASP6

Summary?
GeneID 839
Symbol CASP6
Synonyms MCH2
Description caspase 6
Reference MIM:601532|HGNC:HGNC:1507|Ensembl:ENSG00000138794|HPRD:03321|Vega:OTTHUMG00000131914
Gene type protein-coding
Map location 4q25
Pascal p-value 0.03
eGene Cerebellar Hemisphere
Cerebellum
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0235

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MDS1 0.68 0.64
EVI1 0.68 0.63
CXorf36 0.67 0.67
GIMAP8 0.65 0.62
A2M 0.65 0.64
COBLL1 0.64 0.63
FLI1 0.64 0.60
SLCO2B1 0.64 0.65
CDH5 0.63 0.64
TGFBR2 0.63 0.62
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C12orf45 -0.43 -0.47
RPL31 -0.42 -0.46
RPL27 -0.41 -0.50
RPS20 -0.40 -0.48
SNRPD2 -0.39 -0.43
RPL34 -0.39 -0.44
NDUFAF2 -0.39 -0.42
PFDN2 -0.39 -0.39
RPS25P8 -0.38 -0.44
FAM128B -0.38 -0.44

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005515 protein binding IPI 12888622
GO:0004197 cysteine-type endopeptidase activity IEA -
GO:0008233 peptidase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006508 proteolysis IDA 12888622
GO:0006917 induction of apoptosis TAS 7796396
GO:0006915 apoptosis IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
BIRC6 APOLLON | BRUCE | FLJ13726 | FLJ13786 | KIAA1289 baculoviral IAP repeat-containing 6 BRUCE interacts with Casp-6. This interaction was modeled on a demonstrated interaction between mouse BRUCE and human Casp-6. BIND 15200957
CASP10 ALPS2 | FLICE2 | MCH4 caspase 10, apoptosis-related cysteine peptidase - HPRD,BioGRID 8962078
CASP3 CPP32 | CPP32B | SCA-1 caspase 3, apoptosis-related cysteine peptidase Biochemical Activity BioGRID 8900201
CASP6 MCH2 caspase 6, apoptosis-related cysteine peptidase Biochemical Activity BioGRID 12232792
CASP8 ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473 caspase 8, apoptosis-related cysteine peptidase - HPRD,BioGRID 12232792
CHD3 Mi-2a | Mi2-ALPHA | ZFH chromodomain helicase DNA binding protein 3 Two-hybrid BioGRID 16169070
DSP DPI | DPII desmoplakin - HPRD 15500642
HSPD1 CPN60 | GROEL | HSP60 | HSP65 | HuCHA60 | SPG13 heat shock 60kDa protein 1 (chaperonin) - HPRD,BioGRID 10205159
HTT HD | IT15 huntingtin Htt interacts with caspase 6. BIND 14713958
LMNB1 ADLD | LMN | LMN2 | LMNB | MGC111419 lamin B1 - HPRD 11901153
RB1 OSRC | RB | p105-Rb | pRb | pp110 retinoblastoma 1 CASP6 (caspase-6) cleaves RB-1 (hRB) at the DSID consensus site to produce the p68 form. BIND 15735701
TRAF1 EBI6 | MGC:10353 TNF receptor-associated factor 1 Biochemical Activity BioGRID 11098060
XIAP API3 | BIRC4 | ILP1 | MIHA | XLP2 X-linked inhibitor of apoptosis XIAP interacts with Casp-6. BIND 15200957


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG APOPTOSIS 88 62 All SZGR 2.0 genes in this pathway
BIOCARTA CHEMICAL PATHWAY 22 15 All SZGR 2.0 genes in this pathway
BIOCARTA CASPASE PATHWAY 23 15 All SZGR 2.0 genes in this pathway
BIOCARTA FAS PATHWAY 30 22 All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY 58 43 All SZGR 2.0 genes in this pathway
BIOCARTA DEATH PATHWAY 33 24 All SZGR 2.0 genes in this pathway
BIOCARTA MITOCHONDRIA PATHWAY 21 15 All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY 137 94 All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY 69 51 All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY 84 61 All SZGR 2.0 genes in this pathway
PID HIV NEF PATHWAY 35 26 All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY 52 39 All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 40 26 All SZGR 2.0 genes in this pathway
REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS 13 11 All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 148 94 All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE 54 37 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267 178 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA PROGENITOR DN 66 42 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
LIU CMYB TARGETS UP 165 106 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 128 95 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 All SZGR 2.0 genes in this pathway
林格伦膀胱癌集群1 DN 378 231 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234 147 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION DN 84 54 All SZGR 2.0 genes in this pathway
LANG MYB FAMILY TARGETS 29 16 All SZGR 2.0 genes in this pathway
NUNODA RESPONSE TO DASATINIB IMATINIB UP 29 20 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309 206 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX UP 36 27 All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR UP 37 31 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178 111 All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH UP 74 56 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR DN 160 101 All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS UP 47 31 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14 DELETION DN 60 38 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249 165 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259 185 All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299 189 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D DN 49 34 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN 69 48 All SZGR 2.0 genes in this pathway
RAMPON ENRICHED LEARNING ENVIRONMENT EARLY DN 10 10 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 150 99 All SZGR 2.0 genes in this pathway
国外RB1目标GROWING 243 155 All SZGR 2.0 genes in this pathway
QI HYPOXIA 140 96 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE MIDDLE 98 56 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
郭的目标啊F IRS1 AND IRS2 98 67 All SZGR 2.0 genes in this pathway