SZGR2 - Beplay体育中心

Summary？

基因	842
象征	CASP9
Synonyms	apaf-3 \| apaf3 \| ice-lap6 \| mch6 \| ppp1r56
Description	caspase 9
Reference	MIM：602234\|HGNC：HGNC：1511\|ENSEMBL：ENSG00000132906\|HPRD:03756\|Vega:OTTHUMG00000002256
基因类型	蛋白质编码
Map location	1p36.21
Pascal p-value	0.677
Sherlock p-value	0.329
胎儿β	-1.335
DMG	1(# studies)
主持人	Myers' cis & trans

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
DMG：Wockner_2014	全基因组DNA甲基化分析	该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	染色体	位置	Nearest gene	p（dis）	Beta (dis)	fdr（dis）	学习
CG20153829	1	15848307	CASP9	3.371E-4	0.304	0.041	DMG：Wockner_2014

eQTL annotation

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
RS12718316	CHR7	49035889	CASP9	842		0.05		反式
RS4132419	CHR7	49066632	CASP9	842		0.16		反式

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
CARD11	0.75	0.58
CHRNA2	0.73	0.55
ATP2A3	0.71	0.08
AL133445.2	0.71	0.31
SUSD2	0.71	0.38
EPN3	0.68	0.43
FAM19A4	0.68	0.56
FAM20A	0.68	0.27
CHRNA3	0.68	0.44
PLCB4	0.68	0.34

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
plekho1	-0.18	-0.24
EMID1	-0.17	-0.32
IER5L	-0.16	-0.09
WDR86	-0.16	-0.20
NR2C2AP	-0.15	-0.22
TMEM44	-0.15	-0.18
RPL35	-0.15	-0.30
TMEM159	-0.15	-0.15
RPL18	-0.15	-0.38
CHRDL1	-0.15	-0.09

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
ABL1	ABL \|JTK7 \|BCR/ABL \|c-abl \|P150 \|V-ABL	C-ABL癌基因1，受体酪氨酸激酶	-	HPRD	15657060
APAF1	CED4 \| DKFZp781B1145	apoptotic peptidase activating factor 1	-	HPRD,BioGRID	9390557\|9488720
APAF1	CED4 \| DKFZp781B1145	apoptotic peptidase activating factor 1	APAF1interacts with CASP9.	绑定	15829969
APAF1	CED4 \| DKFZp781B1145	apoptotic peptidase activating factor 1	-	HPRD	9390557\|9488720 \|9539746\|9837928 \|10376594
BCL10	CARMEN \| CIPER \| CLAP \| c-E10 \| mE10	B-cell CLL/lymphoma 10	-	HPRD	10187815
Bcl2l1	BCL-XL/S \| BCL2L \| BCLX \| Bcl-X \| DKFZp781P2092 \| bcl-xL \| bcl-xS	BCL2-like 1	-	HPRD,BioGRID	9539746
BIRC2	API1 \|hiap2 \|hiap-2 \|mihb \|RNF48 \|CIAP1	baculoviral IAP repeat-containing 2	-	HPRD,BioGRID	9545235
BIRC3	AIP1 \|API2 \|CIAP2 \|haip1 \|hiap1 \|MALT2 \|mihc \|RNF49	baculoviral IAP repeat-containing 3	-	HPRD,BioGRID	9545235
Birc5	API4 \| EPR-1	baculoviral IAP repeat-containing 5	-	HPRD,BioGRID	11069302
BIRC6	Apollon \|布鲁斯\|FLJ13726 \|FLJ13786 \|KIAA1289	baculoviral IAP repeat-containing 6	-	HPRD	15300255
BIRC6	Apollon \|布鲁斯\|FLJ13726 \|FLJ13786 \|KIAA1289	baculoviral IAP repeat-containing 6	BRUCE interacts with Casp-9. This interaction was modeled on a demonstrated interaction between mouse BRUCE and human Casp-9.	绑定	15200957
BIRC6	Apollon \|布鲁斯\|FLJ13726 \|FLJ13786 \|KIAA1289	baculoviral IAP repeat-containing 6	Apollon与caspase-9相互作用并泛素化。	绑定	15300255
Birc7	KIAP \| LIVIN \| ML-IAP \| MLIAP \| RNF50	baculoviral IAP repeat-containing 7	-	HPRD,BioGRID	11024045
BIRC8	ILP-2 \| ILP2 \| hILP2	baculoviral IAP repeat-containing 8	-	HPRD,BioGRID	11390657
卡8	红衣主教\|达卡\|DKFZP779L0366 \|达喀尔\|FLJ18119 \|FLJ18121 \|KIAA0955 \|MGC57162 \|NDPP \|NDPP1 \| TUCAN	caspase recruitment domain family, member 8	-	HPRD	11408476
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10，与凋亡相关的半胱氨酸肽酶	-	HPRD,BioGRID	8962078
CASP2	CASP-2 \|ICH-1L \|ICH-1L/1S \|ICH1 \|nedd2	caspase 2，与凋亡相关的半胱氨酸肽酶	表型抑制	Biogrid	11832478
CASP3	CPP32 \|CPP32B \|SCA-1	caspase 3, apoptosis-related cysteine peptidase	-	HPRD	11230124
CASP8	ALPS2B \|cap4 \|弗里斯\|FLJ17672 \|马赫\|MCH5 \|MGC78473	caspase 8, apoptosis-related cysteine peptidase	生化活动表型抑制	Biogrid	8962078\|11832478
CASP9	APAF-3 \| APAF3 \| CASPASE-9c \| ICE-LAP6 \| MCH6	caspase 9, apoptosis-related cysteine peptidase	-	HPRD	9651578
CYCS	CYC \|HCS	细胞色素C，体细胞	-	HPRD	12147322
DCC	CRC18 \| CRCR1	deleted in colorectal carcinoma	-	HPRD,BioGRID	11248093
DSP	DPI \| DPII	脱莫普拉金	-	HPRD	15500642
GZMB	CCPI \| CGL-1 \| CGL1 \| CSP-B \| CSPB \| CTLA1 \| CTSGL1 \| HLP \| SECT	颗粒酶B（颗粒酶2，细胞毒性T淋巴细胞相关丝氨酸酯酶1）	-	HPRD	8900201
HSPD1	CPN60 \|凹槽\|HSP60 \|HSP65 \|hucha60 \|SPG13	热休克60KDA蛋白1（伴侣蛋白）	-	HPRD	11230124
MAPK1	ERK \|ERK2 \|ERT1 \|MAPK2 \|p42mapk \|prkm1 \|prkm2 \|p38 \|P40 \|P41 \| p41mapk	有丝分裂原激活的蛋白激酶1	-	HPRD,BioGRID	12792650
MAPK3	ERK1 \|HS44KDAP \|Humker1a \|MGC20180 \|p44erk1 \|p44mapk \|prkm3	有丝分裂原激活的蛋白激酶3	-	HPRD	12792650
MGC29506	FLJ32987 \|PACAP	假设蛋白MGC29506	-	HPRD	11350957
NAIP	Birc1 \|FLJ18088 \|FLJ42520 \|FLJ58811 \|NLRB1 \|psinaip	NLR家族，凋亡抑制蛋白	-	HPRD,BioGRID	15280366
NLRP1	card7 \|Clr17.1 \|defcap \|defcap-l/s \|DKFZP586O1822 \|KIAA0926 \|NAC \|nalp1 \|pp1044 \|slev1 \| VAMAS1	NLR家族，含有1个	-	HPRD,BioGRID	11076957
NOD1	card4 \|Clr7.1 \|NLRC1	包含1个的核苷酸结合寡聚结构域	NOD1与Caspase-9相互作用并调节	绑定	10329646
NOD1	card4 \|Clr7.1 \|NLRC1	包含1个的核苷酸结合寡聚结构域	-	HPRD,BioGRID	10329646
RB1	OSRC \|RB \|P105-RB \|PRB \|PP110	retinoblastoma 1	CASP9（caspase-9）在贷款共识部位切割RB-1（HRB）以产生p76形式。	绑定	15735701
XIAP	API3 \|Birc4 \|ILP1 \|miha \|XLP2	X-linked inhibitor of apoptosis	XIAP与caspase-9相互作用并泛素化。	绑定	15300255
XIAP	API3 \|Birc4 \|ILP1 \|miha \|XLP2	X-linked inhibitor of apoptosis	亲和力捕获 - 韦斯特恩 Far Western 重构的复合物 Two-hybrid	Biogrid	9545235\|11390657 \|15280366\|16189514
XIAP	API3 \|Birc4 \|ILP1 \|miha \|XLP2	X-linked inhibitor of apoptosis	-	HPRD	9545235\|11927604

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG P53信号通路	69	45	All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS	88	62	All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY	76	53	All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
KEGG PARKINSONS DISEASE	133	78	All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS	53	43	All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE	185	109	All SZGR 2.0 genes in this pathway
癌症中的KEGG途径	328	259	All SZGR 2.0 genes in this pathway
KEGG结直肠癌	62	47	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER	52	45	All SZGR 2.0 genes in this pathway
KEGG前列腺癌	89	75	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER	54	47	All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS	73	58	All SZGR 2.0 genes in this pathway
BIOCARTA AKT PATHWAY	22	16	All SZGR 2.0 genes in this pathway
生物卡尔塔化学途径	22	15	All SZGR 2.0 genes in this pathway
BIOCARTA CASPASE PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA D4GDI PATHWAY	13	8	All SZGR 2.0 genes in this pathway
Biocarta Hivnef途径	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA DEATH PATHWAY	33	24	All SZGR 2.0 genes in this pathway
Biocarta RAS途径	23	20	All SZGR 2.0 genes in this pathway
BIOCARTA MITOCHONDRIA PATHWAY	21	15	All SZGR 2.0 genes in this pathway
Biocarta HSP27途径	15	11	All SZGR 2.0 genes in this pathway
Biocarta TFF途径	21	15	All SZGR 2.0 genes in this pathway
SA CASPASE CASCADE	19	13	All SZGR 2.0 genes in this pathway
SA编程的细胞死亡	12	9	All SZGR 2.0 genes in this pathway
PID P75 NTR途径	69	51	All SZGR 2.0 genes in this pathway
PID HIV NEF PATHWAY	35	26	All SZGR 2.0 genes in this pathway
PID caspase途径	52	39	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
SCF套件的Reactome信号传导	78	59	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
EGFR在癌症中的反应组信号传导	109	80	All SZGR 2.0 genes in this pathway
ERBB4信号中的Reactome PI3K事件	38	28	All SZGR 2.0 genes in this pathway
ERBB2信号中的Reactome PI3K事件	44	34	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	97	66	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	126	90	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME PI3K AKT ACTIVATION	38	29	All SZGR 2.0 genes in this pathway
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	12	10	All SZGR 2.0 genes in this pathway
REACTOME GAB1 SIGNALOSOME	38	29	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF APOPTOSIS	58	34	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
Reactome Pi 3K级联	56	39	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
DCC在调节凋亡中的反应组作用	10	5	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
Reactome先天免疫系统	279	178	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统	539	350	All SZGR 2.0 genes in this pathway
REACTOME NOD1 2 SIGNALING PATHWAY	30	22	All SZGR 2.0 genes in this pathway
Reactome Pip3激活Akt信号传导	29	20	All SZGR 2.0 genes in this pathway
反应组核苷酸结合结构域富含受体NLR信号通路富含亮氨酸的重复途径	46	33	All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导	112	80	All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	30	21	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 DN	52	34	All SZGR 2.0 genes in this pathway
Chemnitz对前列腺素E2 DN的反应	391	222	All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN	186	114	All SZGR 2.0 genes in this pathway
Nagashima NRG1信号向上发出	176	123	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
Berenjeno由Rhoa DN转变	394	258	All SZGR 2.0 genes in this pathway
标记HDAC目标	23	15	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
TSUNODA CISPLATIN RESISTANCE DN	51	38	All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向胎儿肝DN	514	319	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
Koyama Sema3b靶向	292	168	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
Benporath SOX2目标	734	436	All SZGR 2.0 genes in this pathway
Mori前BI淋巴细胞DN	77	49	All SZGR 2.0 genes in this pathway
Tenedini Megakaryocyte标记	66	48	All SZGR 2.0 genes in this pathway
费尔南德斯（Fernandez）由迈克（Myc）约束	182	116	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA DN	39	29	All SZGR 2.0 genes in this pathway
皮肤上的theilgaard中性粒细胞	77	52	All SZGR 2.0 genes in this pathway
Xu Crebbp目标DN	44	31	All SZGR 2.0 genes in this pathway
iglesias e2f目标dn	16	11	All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP	71	49	All SZGR 2.0 genes in this pathway
Chiba对TSA的反应	52	33	All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病	1691	1088	All SZGR 2.0 genes in this pathway
GAJATE RESPONSE TO TRABECTEDIN UP	67	45	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP	388	234	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP	439	257	All SZGR 2.0 genes in this pathway
西肾上腺皮质肿瘤DN	546	362	All SZGR 2.0 genes in this pathway
CLIMENT BREAST CANCER COPY NUMBER DN	8	7	All SZGR 2.0 genes in this pathway
BREDEMEYER RAG SIGNALING VIA ATM NOT VIA NFKB DN	38	23	All SZGR 2.0 genes in this pathway
Mueller Plurinet	299	189	All SZGR 2.0 genes in this pathway
NICK RESPONSE TO PROC TREATMENT DN	27	18	All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS	535	325	All SZGR 2.0 genes in this pathway
Sakai慢性肝炎与肝癌	83	63	All SZGR 2.0 genes in this pathway
由MYC约束	1103	714	All SZGR 2.0 genes in this pathway
萨森对促性腺营养蛋白的反应	91	59	All SZGR 2.0 genes in this pathway
Sasson对Forskolin的反应	90	58	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
wakabayashi脂肪形成PPARG绑定8D	658	397	All SZGR 2.0 genes in this pathway
Zwang 3类由EGF瞬时诱导	222	159	All SZGR 2.0 genes in this pathway

Gene Page:CASP9