Gene Page:DHX16

Summary?
GeneID 8449
Symbol DHX16
Synonyms DBP2|DDX16|PRO2014|PRP8|PRPF2|Prp2
Description DEAH-box helicase 16
Reference MIM:603405|HGNC:HGNC:2739|Ensembl:ENSG00000204560|HPRD:04555|Vega:OTTHUMG00000031060
Gene type protein-coding
Map location 6p21.3
Pascal p-value 4.552E-15
Sherlock p-value 0.619
Fetal beta 0.134
eGene Cerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
GSMA_I Genome scan meta-analysis Psr: 0.033

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17072268 chr13 49383760 DHX16 8449 0.05 trans
rs16955618 chr15 29937543 DHX16 8449 0.05 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ATHL1 0.57 0.62
PEAR1 0.57 0.62
SNED1 0.57 0.64
ADAM33 0.56 0.64
TENC1 0.56 0.58
ITIH4 0.56 0.58
ABCA9 0.56 0.64
AC055839.1 0.56 0.61
WIPI1 0.55 0.55
COL16A1 0.54 0.58
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PFDN2 -0.40 -0.43
TMSB10 -0.38 -0.44
MED19 -0.38 -0.42
C19orf43 -0.37 -0.40
ALKBH2 -0.37 -0.43
LSM7 -0.37 -0.43
C12orf45 -0.37 -0.45
FAM128B -0.36 -0.47
RPL31 -0.36 -0.49
STRA13 -0.36 -0.47

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0003676 nucleic acid binding IEA -
GO:0003724 RNA helicase activity TAS 9547260
GO:0005524 ATP binding IEA -
GO:0016787 hydrolase activity IEA -
GO:0008026 ATP-dependent helicase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006397 mRNA processing IEA -
GO:0008380 RNA splicing TAS 9547260
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus TAS 9547260

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG SPLICEOSOME 128 72 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180 101 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
LIU BREAST CANCER 30 19 All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 24HR DN 33 21 All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161 105 All SZGR 2.0 genes in this pathway
LEE METASTASIS AND RNA PROCESSING UP 17 9 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway