Gene Page:MCM8

概括?
GeneID 84515
Symbol MCM8
Synonyms C20orf154|POF10|dJ967N21.5
Description minichromosome maintenance 8 homologous recombination repair factor
Reference MIM:608187|HGNC：HGNC：16147|Ensembl:ENSG00000125885|HPRD:12186|Vega：Otthumg0000000031822
Gene type protein-coding
Map location 20p12.3
Pascal p-value 0.596
Sherlock p-value 0.422
Fetal beta 1.207
eGene Anterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
额叶皮质BA9
Hippocampus
下丘脑
Nucleus accumbens basal ganglia
Putamen basal ganglia

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
CV:PheWAS Phenome-wide association studies (PheWAS) 157 SNPs associated with schizophrenia 1

第一节遗传学和表观遗传学注释

@CV:PheWAS

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs16991615 20 5948227 null 1.883 MCM8 null

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs397732967 20 5932104 MCM8 ENSG00000125885.9 4.11E-7 0.01 806 gtex_brain_ba24
rs236118 20 5938207 MCM8 ENSG00000125885.9 1.435E-8 0.01 6909 gtex_brain_ba24
rs236119 20 5938654 MCM8 ENSG00000125885.9 1.068E-7 0.01 7356 gtex_brain_ba24
rs2326680 20 5942955 MCM8 ENSG00000125885.9 2.826E-7 0.01 11657 gtex_brain_ba24
rs409035 20 5943649 MCM8 ENSG00000125885.9 2.826E-7 0.01 12351 gtex_brain_ba24
rs454422 20 5943693 MCM8 ENSG00000125885.9 2.826E-7 0.01 12395 gtex_brain_ba24
rs236104 20 5958960 MCM8 ENSG00000125885.9 2.826E-7 0.01 27662 gtex_brain_ba24
rs236106 20 5960691 MCM8 ENSG00000125885.9 2.826E-7 0.01 29393 gtex_brain_ba24
rs13041190 20 5961458 MCM8 ENSG00000125885.9 1.435E-8 0.01 30160 gtex_brain_ba24
rs180477 20 5967744 MCM8 ENSG00000125885.9 2.822E-7 0.01 36446 gtex_brain_ba24
rs6053815 20 5970438 MCM8 ENSG00000125885.9 2.82E-7 0.01 39140 gtex_brain_ba24
rs6053816 20 5970750 MCM8 ENSG00000125885.9 2.819E-7 0.01 39452 gtex_brain_ba24
rs236121 20 5972594 MCM8 ENSG00000125885.9 2.818E-7 0.01 41296 gtex_brain_ba24
rs35653279 20 5974704 MCM8 ENSG00000125885.9 6.486E-7 0.01 43406 gtex_brain_ba24
rs236126 20 5978141 MCM8 ENSG00000125885.9 1.419E-8 0.01 46843 gtex_brain_ba24
RS397689224 20 5979861 MCM8 ENSG00000125885.9 5.679E-7 0.01 48563 gtex_brain_ba24
rs4813785 20 5983436 MCM8 ENSG00000125885.9 3.965E-8 0.01 52138 gtex_brain_ba24
rs6053797 20 5916096 MCM8 ENSG00000125885.9 6.144E-7 0 -15202 gtex_brain_putamen_basal
rs397732967 20 5932104 MCM8 ENSG00000125885.9 9.509E-10 0 806 gtex_brain_putamen_basal
rs236110 20 5933108 MCM8 ENSG00000125885.9 1.022E-6 0 1810 gtex_brain_putamen_basal
rs236112 20 5934319 MCM8 ENSG00000125885.9 1.022E-6 0 3021 gtex_brain_putamen_basal
rs236115 20 5935449 MCM8 ENSG00000125885.9 1.022E-6 0 4151 gtex_brain_putamen_basal
rs236118 20 5938207 MCM8 ENSG00000125885.9 2.304E-9 0 6909 gtex_brain_putamen_basal
rs200713657 20 5938653 MCM8 ENSG00000125885.9 2.613E-9 0 7355 gtex_brain_putamen_basal
rs236119 20 5938654 MCM8 ENSG00000125885.9 9.147E-12 0 7356 gtex_brain_putamen_basal
rs71334368 20 5939638 MCM8 ENSG00000125885.9 6.46E-7 0 8340 gtex_brain_putamen_basal
rs11483684 20 5939644 MCM8 ENSG00000125885.9 2.121E-6 0 8346 gtex_brain_putamen_basal
rs236120 20 5939649 MCM8 ENSG00000125885.9 1.025E-6 0 8351 gtex_brain_putamen_basal
RS379418 20 5942207 MCM8 ENSG00000125885.9 1.022E-6 0 10909 gtex_brain_putamen_basal
rs2326680 20 5942955 MCM8 ENSG00000125885.9 1.153E-9 0 11657 gtex_brain_putamen_basal
rs409035 20 5943649 MCM8 ENSG00000125885.9 1.153E-9 0 12351 gtex_brain_putamen_basal
rs454422 20 5943693 MCM8 ENSG00000125885.9 1.153E-9 0 12395 gtex_brain_putamen_basal
RS12106220 20 5944255 MCM8 ENSG00000125885.9 1.022E-6 0 12957 gtex_brain_putamen_basal
rs11468712 20 5948421 MCM8 ENSG00000125885.9 8.927E-7 0 17123 gtex_brain_putamen_basal
rs236102 20 5951966 MCM8 ENSG00000125885.9 1.022E-6 0 20668 gtex_brain_putamen_basal
rs12624735 20 5956166 MCM8 ENSG00000125885.9 1.638E-6 0 24868 gtex_brain_putamen_basal
rs236104 20 5958960 MCM8 ENSG00000125885.9 1.153E-9 0 27662 gtex_brain_putamen_basal
rs236105 20 5959832 MCM8 ENSG00000125885.9 1.022E-6 0 28534 gtex_brain_putamen_basal
rs236106 20 5960691 MCM8 ENSG00000125885.9 1.153E-9 0 29393 gtex_brain_putamen_basal
rs13041190 20 5961458 MCM8 ENSG00000125885.9 2.304E-9 0 30160 gtex_brain_putamen_basal
rs236107 20 5965731 MCM8 ENSG00000125885.9 1.022E-6 0 34433 gtex_brain_putamen_basal
rs180477 20 5967744 MCM8 ENSG00000125885.9 1.143E-9 0 36446 gtex_brain_putamen_basal
rs236108 20 5968559 MCM8 ENSG00000125885.9 1.022E-6 0 37261 gtex_brain_putamen_basal
rs6053815 20 5970438 MCM8 ENSG00000125885.9 1.135E-9 0 39140 gtex_brain_putamen_basal
rs6053816 20 5970750 MCM8 ENSG00000125885.9 1.134E-9 0 39452 gtex_brain_putamen_basal
rs236121 20 5972594 MCM8 ENSG00000125885.9 1.132E-9 0 41296 gtex_brain_putamen_basal
rs236122 20 5973528 MCM8 ENSG00000125885.9 6.604E-7 0 42230 gtex_brain_putamen_basal
rs35653279 20 5974704 MCM8 ENSG00000125885.9 1.729E-7 0 43406 gtex_brain_putamen_basal
rs236124 20 5975979 MCM8 ENSG00000125885.9 7.417E-7 0 44681 gtex_brain_putamen_basal
rs236125 20 5976974 MCM8 ENSG00000125885.9 6.303E-7 0 45676 gtex_brain_putamen_basal
rs236126 20 5978141 MCM8 ENSG00000125885.9 4.46E-9 0 46843 gtex_brain_putamen_basal
RS397689224 20 5979861 MCM8 ENSG00000125885.9 3.302E-9 0 48563 gtex_brain_putamen_basal
rs6053817 20 5980698 MCM8 ENSG00000125885.9 2.509E-7 0 49400 gtex_brain_putamen_basal
rs384578 20 5981476 MCM8 ENSG00000125885.9 4.335E-7 0 50178 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME激活之前复制的COMPLEX 31 16 该途径中的所有SZGR 2.0基因
REACTOME CELL CYCLE 421 253 该途径中的所有SZGR 2.0基因
REACTOME ORC1 REMOVAL FROM CHROMATIN 67 37 该途径中的所有SZGR 2.0基因
REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION 10 5 该途径中的所有SZGR 2.0基因
REACTOME CELL CYCLE MITOTIC 325 185 该途径中的所有SZGR 2.0基因
REACTOME CELL CYCLE CHECKPOINTS 124 70 该途径中的所有SZGR 2.0基因
REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX 11 5 该途径中的所有SZGR 2.0基因
REACTOME M G1 TRANSITION 81 45 该途径中的所有SZGR 2.0基因
REACTOME G1 S TRANSITION 112 63 该途径中的所有SZGR 2.0基因
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX 56 31 该途径中的所有SZGR 2.0基因
DNA的反应组合成 92 53 该途径中的所有SZGR 2.0基因
REACTOME MITOTIC G1 G1 S PHASES 137 79 该途径中的所有SZGR 2.0基因
REACTOME MITOTIC M M G1 PHASES 172 98 该途径中的所有SZGR 2.0基因
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 65 36 该途径中的所有SZGR 2.0基因
REACTOME DNA REPLICATION 192 110 该途径中的所有SZGR 2.0基因
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION 35 17 该途径中的所有SZGR 2.0基因
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 38 18 该途径中的所有SZGR 2.0基因
REACTOME UNWINDING OF DNA 11 6 该途径中的所有SZGR 2.0基因
REACTOME G2 M CHECKPOINTS 45 23 该途径中的所有SZGR 2.0基因
REACTOME S PHASE 109 66 该途径中的所有SZGR 2.0基因
REACTOME DNA STRAND ELONGATION 30 18 该途径中的所有SZGR 2.0基因
PYEON HPV POSITIVE TUMORS UP 98 47 该途径中的所有SZGR 2.0基因
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294 178 该途径中的所有SZGR 2.0基因
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 该途径中的所有SZGR 2.0基因
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 该途径中的所有SZGR 2.0基因
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 该途径中的所有SZGR 2.0基因
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 该途径中的所有SZGR 2.0基因
NUYTTEN EZH2 TARGETS DN 1024 594 该途径中的所有SZGR 2.0基因
WEI MYCN TARGETS WITH E BOX 795 478 该途径中的所有SZGR 2.0基因
BENPORATH CYCLING GENES 648 385 该途径中的所有SZGR 2.0基因
KAUFFMANN DNA REPLICATION GENES 147 87 该途径中的所有SZGR 2.0基因
Vernell视网膜母细胞瘤路径 70 47 该途径中的所有SZGR 2.0基因
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 该途径中的所有SZGR 2.0基因
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 该途径中的所有SZGR 2.0基因
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 该途径中的所有SZGR 2.0基因
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 该途径中的所有SZGR 2.0基因
CHANG CYCLING GENES 148 83 该途径中的所有SZGR 2.0基因
WHITFIELD CELL CYCLE S 162 86 该途径中的所有SZGR 2.0基因
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374 217 该途径中的所有SZGR 2.0基因
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229 149 该途径中的所有SZGR 2.0基因
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324 193 该途径中的所有SZGR 2.0基因
THILLAINADESAN ZNF217 TARGETS UP 44 22 该途径中的所有SZGR 2.0基因
JOHNSTONE PARVB TARGETS 3 DN 918 550 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 该途径中的所有SZGR 2.0基因
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR 128 73 该途径中的所有SZGR 2.0基因