Gene Page:PPP1R9B

Summary?
GeneID 84687
Symbol PPP1R9B
Synonyms PPP1R6|PPP1R9|SPINO|Spn
Description protein phosphatase 1 regulatory subunit 9B
Reference MIM:603325|HGNC:HGNC:9298|Ensembl:ENSG00000108819|HPRD:04506|Vega:OTTHUMG00000162008
Gene type protein-coding
Map location 17q21.33
Pascal p-value 0.287
Fetal beta 0.115
Support INTRACELLULAR SIGNAL TRANSDUCTION
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.humanPSD
G2Cdb.humanPSP
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed的基因co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.9202

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003779 actin binding IEA -
GO:0005515 protein binding 新闻学会 11278317
GO:0004864 protein phosphatase inhibitor activity NAS 11278317
GO:0008157 protein phosphatase 1 binding NAS 11278317
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007399 nervous system development IEA neurite (GO term level: 5) -
GO:0001560 regulation of cell growth by extracellular stimulus TAS 11278317
GO:0008380 RNA splicing NAS 11278317
GO:0007050 cell cycle arrest TAS 11278317
GO:0007096 regulation of exit from mitosis NAS 11278317
GO:0007275 multicellular organismal development IEA -
GO:0030154 cell differentiation IEA -
GO:0042127 regulation of cell proliferation NAS 11278317
GO:0030308 negative regulation of cell growth IDA 11278317
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0042995 cell projection IEA axon (GO term level: 4) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0000164 protein phosphatase type 1 complex TAS 11278317
GO:0005856 cytoskeleton IEA -
GO:0005634 nucleus IEA -
GO:0005654 nucleoplasm IMP 11278317
GO:0005737 cytoplasm IDA 11278317
GO:0030054 cell junction IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ACTA1 ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3 actin, alpha 1, skeletal muscle Reconstituted Complex BioGRID 12417592
ACTC1 ACTC | CMD1R | CMH11 actin, alpha, cardiac muscle 1 - HPRD 12270929|12417592
ADRA1A ADRA1C | ADRA1L1 | ALPHA1AAR adrenergic, alpha-1A-, receptor - HPRD 11154706
ADRA2A ADRA2 | ADRA2R | ADRAR | ALPHA2AAR | ZNF32 adrenergic, alpha-2A-, receptor Reconstituted Complex BioGRID 11154706
ADRA2B ADRA2L1 | ADRA2RL1 | ADRARL1 | ALPHA2BAR adrenergic, alpha-2B-, receptor Reconstituted Complex BioGRID 11154706
ADRA2C ADRA2L2 | ADRA2RL2 | ADRARL2 | ALPHA2CAR adrenergic, alpha-2C-, receptor Reconstituted Complex BioGRID 11154706
CDKN2A 东盟地区论坛| CDK4I | CDKN2 | CMM2 | INK4 | INK4a |传销|MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19 cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) - HPRD,BioGRID 11278317
CDKN2A 东盟地区论坛| CDK4I | CDKN2 | CMM2 | INK4 | INK4a |传销|MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19 cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) SPINO interacts with p14ARF. BIND 11278317
DCX DBCN | DC | LISX | SCLH | XLIS doublecortin - HPRD 14550532
DRD2 D2DR | D2R dopamine receptor D2 - HPRD,BioGRID 10391935
PPP1CA MGC15877 | MGC1674 | PP-1A | PPP1A protein phosphatase 1, catalytic subunit, alpha isoform Affinity Capture-Western
Reconstituted Complex		 BioGRID 10194355
PPP1CB MGC3672 | PP-1B | PPP1CD protein phosphatase 1, catalytic subunit, beta isoform Affinity Capture-Western
Reconstituted Complex		 BioGRID 10194355
PPP1CC PPP1G protein phosphatase 1, catalytic subunit, gamma isoform Affinity Capture-Western
Reconstituted Complex		 BioGRID 10194355|10391935
PPP1R2 IPP2 | MGC87148 protein phosphatase 1, regulatory (inhibitor) subunit 2 - HPRD,BioGRID 12270929
PPP1R9A FLJ20068 | KIAA1222 | NRB1 | NRBI | Neurabin-I protein phosphatase 1, regulatory (inhibitor) subunit 9A - HPRD 10514494
PPYR1 MGC116897 | NPY4-R | NPY4R | PP1 | Y4 pancreatic polypeptide receptor 1 - HPRD 10194355|10391935
|12270929
RASGRF1 CDC25 | CDC25L | GNRP | GRF1 | GRF55 | H-GRF55 | PP13187 Ras protein-specific guanine nucleotide-releasing factor 1 Affinity Capture-Western BioGRID 12531897
TGOLN2 MGC14722 | TGN38 | TGN46 | TGN48 | TGN51 | TTGN2 trans-golgi network protein 2 - HPRD,BioGRID 10514494
TIAM1 FLJ36302 T-cell lymphoma invasion and metastasis 1 - HPRD,BioGRID 12531897


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
LIU SOX4 TARGETS DN 309 191 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN 110 78 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
LEIN LOCALIZED TO DISTAL AND PROXIMAL DENDRITES 17 12 All SZGR 2.0 genes in this pathway
SENGUPTA EBNA1 ANTICORRELATED 173 85 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP 140 94 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-125/351 146 152 1A hsa-miR-125bbrain UCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrain UCCCUGAGACCCUUUAACCUGUG
miR-133 1143 1149 1A hsa-miR-133a UUGGUCCCCUUCAACCAGCUGU
hsa-miR-133b UUGGUCCCCUUCAACCAGCUA
hsa-miR-133a UUGGUCCCCUUCAACCAGCUGU
hsa-miR-133b UUGGUCCCCUUCAACCAGCUA
miR-148/152 619 626 1A,m8 hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-182 759 765 1A hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-200bc/429 1316 1322 m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-216 440 446 m8 hsa-miR-216 UAAUCUCAGCUGGCAACUGUG
miR-335 431 437 1A hsa-miR-335brain UCAAGAGCAAUAACGAAAAAUGU
miR-34/449 311 317 1A hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-346 192 199 1A,m8 hsa-miR-346brain UGUCUGCCCGCAUGCCUGCCUCU
miR-96 758 765 1A,m8 hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC