创e Page:ZNF577
Summary?
| 创eID | 84765 |
| Symbol | ZNF577 |
| Synonyms | - |
| Description | zinc finger protein 577 |
| Reference | HGNC:HGNC:28673|Ensembl:ENSG00000161551|HPRD:15856|Vega:OTTHUMG00000157045 |
| 创e type | protein-coding |
| Map location | 19q13.41 |
| Pascal p-value | 0.004 |
| Sherlock p-value | 0.182 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia |
创e in Data Sources
| 创e set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | 创ome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | 创e Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7251993 | 19 | 52351965 | ZNF577 | ENSG00000161551.8 | 4.278E-7 | 0 | 39268 | gtex_brain_ba24 |
| rs7252002 | 19 | 52351993 | ZNF577 | ENSG00000161551.8 | 2.269E-9 | 0 | 39240 | gtex_brain_ba24 |
| rs7252006 | 19 | 52352006 | ZNF577 | ENSG00000161551.8 | 2.398E-11 | 0 | 39227 | gtex_brain_ba24 |
| rs7252110 | 19 | 52352015 | ZNF577 | ENSG00000161551.8 | 2.342E-11 | 0 | 39218 | gtex_brain_ba24 |
| rs7252849 | 19 | 52352440 | ZNF577 | ENSG00000161551.8 | 5.6E-10 | 0 | 38793 | gtex_brain_ba24 |
| rs10421731 | 19 | 52353109 | ZNF577 | ENSG00000161551.8 | 4.769E-10 | 0 | 38124 | gtex_brain_ba24 |
| rs7256792 | 19 | 52353249 | ZNF577 | ENSG00000161551.8 | 4.822E-10 | 0 | 37984 | gtex_brain_ba24 |
| rs6509575 | 19 | 52353437 | ZNF577 | ENSG00000161551.8 | 5.692E-12 | 0 | 37796 | gtex_brain_ba24 |
| rs2191669 | 19 | 52353761 | ZNF577 | ENSG00000161551.8 | 1.251E-12 | 0 | 37472 | gtex_brain_ba24 |
| rs2215518 | 19 | 52353805 | ZNF577 | ENSG00000161551.8 | 9.616E-13 | 0 | 37428 | gtex_brain_ba24 |
| rs13382098 | 19 | 52354381 | ZNF577 | ENSG00000161551.8 | 1.199E-12 | 0 | 36852 | gtex_brain_ba24 |
| rs7249718 | 19 | 52354972 | ZNF577 | ENSG00000161551.8 | 8.433E-13 | 0 | 36261 | gtex_brain_ba24 |
| rs10409522 | 19 | 52355333 | ZNF577 | ENSG00000161551.8 | 8.37E-13 | 0 | 35900 | gtex_brain_ba24 |
| rs397966537 | 19 | 52355856 | ZNF577 | ENSG00000161551.8 | 8.424E-13 | 0 | 35377 | gtex_brain_ba24 |
| rs7255208 | 19 | 52356135 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 35098 | gtex_brain_ba24 |
| rs74651958 | 19 | 52356623 | ZNF577 | ENSG00000161551.8 | 1.512E-11 | 0 | 34610 | gtex_brain_ba24 |
| rs201879463 | 19 | 52356627 | ZNF577 | ENSG00000161551.8 | 4.084E-7 | 0 | 34606 | gtex_brain_ba24 |
| rs7256036 | 19 | 52356791 | ZNF577 | ENSG00000161551.8 | 1.097E-9 | 0 | 34442 | gtex_brain_ba24 |
| rs10424176 | 19 | 52357178 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 34055 | gtex_brain_ba24 |
| rs10423844 | 19 | 52357203 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 34030 | gtex_brain_ba24 |
| rs56406030 | 19 | 52357458 | ZNF577 | ENSG00000161551.8 | 1.097E-11 | 0 | 33775 | gtex_brain_ba24 |
| rs10424471 | 19 | 52357472 | ZNF577 | ENSG00000161551.8 | 1.126E-12 | 0 | 33761 | gtex_brain_ba24 |
| rs112952722 | 19 | 52357738 | ZNF577 | ENSG00000161551.8 | 8.872 e-12 | 0 | 33495 | gtex_brain_ba24 |
| rs11883265 | 19 | 52357777 | ZNF577 | ENSG00000161551.8 | 1.84 e-12 | 0 | 33456 | gtex_brain_ba24 |
| rs11883230 | 19 | 52357805 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 33428 | gtex_brain_ba24 |
| rs6509576 | 19 | 52358023 | ZNF577 | ENSG00000161551.8 | 1.421E-11 | 0 | 33210 | gtex_brain_ba24 |
| rs6509577 | 19 | 52358119 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 33114 | gtex_brain_ba24 |
| rs8102206 | 19 | 52358269 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 32964 | gtex_brain_ba24 |
| rs34540338 | 19 | 52358593 | ZNF577 | ENSG00000161551.8 | 6.79E-13 | 0 | 32640 | gtex_brain_ba24 |
| rs1056294 | 19 | 52359169 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 32064 | gtex_brain_ba24 |
| rs11671807 | 19 | 52359502 | ZNF577 | ENSG00000161551.8 | 1.238E-12 | 0 | 31731 | gtex_brain_ba24 |
| rs7253396 | 19 | 52359605 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 31628 | gtex_brain_ba24 |
| rs3752124 | 19 | 52359868 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 31365 | gtex_brain_ba24 |
| rs7255924 | 19 | 52359874 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 31359 | gtex_brain_ba24 |
| rs3752123 | 19 | 52359983 | ZNF577 | ENSG00000161551.8 | 1.238E-12 | 0 | 31250 | gtex_brain_ba24 |
| rs3752122 | 19 | 52360097 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 31136 | gtex_brain_ba24 |
| rs3752121 | 19 | 52360112 | ZNF577 | ENSG00000161551.8 | 1.238E-12 | 0 | 31121 | gtex_brain_ba24 |
| rs397950142 | 19 | 52360193 | ZNF577 | ENSG00000161551.8 | 6.991E-12 | 0 | 31040 | gtex_brain_ba24 |
| rs6509578 | 19 | 52360278 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 30955 | gtex_brain_ba24 |
| rs6509579 | 19 | 52360441 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 30792 | gtex_brain_ba24 |
| rs6509580 | 19 | 52360518 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 30715 | gtex_brain_ba24 |
| rs10642180 | 19 | 52360586 | ZNF577 | ENSG00000161551.8 | 1.06E-12 | 0 | 30647 | gtex_brain_ba24 |
| rs200930484 | 19 | 52360610 | ZNF577 | ENSG00000161551.8 | 8.882E-10 | 0 | 30623 | gtex_brain_ba24 |
| rs10421236 | 19 | 52360618 | ZNF577 | ENSG00000161551.8 | 8.594E-8 | 0 | 30615 | gtex_brain_ba24 |
| rs72213862 | 19 | 52360673 | ZNF577 | ENSG00000161551.8 | 6.156E-9 | 0 | 30560 | gtex_brain_ba24 |
| rs201458902 | 19 | 52360677 | ZNF577 | ENSG00000161551.8 | 1.472E-9 | 0 | 30556 | gtex_brain_ba24 |
| rs11665778 | 19 | 52360813 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 30420 | gtex_brain_ba24 |
| rs11669509 | 19 | 52360842 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 30391 | gtex_brain_ba24 |
| rs765010 | 19 | 52361358 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 29875 | gtex_brain_ba24 |
| rs765009 | 19 | 52361834 | ZNF577 | ENSG00000161551.8 | 8.735E-13 | 0 | 29399 | gtex_brain_ba24 |
| rs11672786 | 19 | 52361981 | ZNF577 | ENSG00000161551.8 | 1.421E-11 | 0 | 29252 | gtex_brain_ba24 |
| rs62107503 | 19 | 52362158 | ZNF577 | ENSG00000161551.8 | 8.947E-12 | 0 | 29075 | gtex_brain_ba24 |
| rs200979439 | 19 | 52364546 | ZNF577 | ENSG00000161551.8 | 4.062E-8 | 0 | 26687 | gtex_brain_ba24 |
| rs8106102 | 19 | 52364547 | ZNF577 | ENSG00000161551.8 | 3.471E-9 | 0 | 26686 | gtex_brain_ba24 |
| rs8113216 | 19 | 52366691 | ZNF577 | ENSG00000161551.8 | 1.097E-9 | 0 | 24542 | gtex_brain_ba24 |
| rs8100840 | 19 | 52370512 | ZNF577 | ENSG00000161551.8 | 7.853E-10 | 0 | 20721 | gtex_brain_ba24 |
| rs10408912 | 19 | 52370845 | ZNF577 | ENSG00000161551.8 | 1.622E-9 | 0 | 20388 | gtex_brain_ba24 |
| rs7251070 | 19 | 52371797 | ZNF577 | ENSG00000161551.8 | 1.097E-9 | 0 | 19436 | gtex_brain_ba24 |
| rs6509585 | 19 | 52374118 | ZNF577 | ENSG00000161551.8 | 2.725E-9 | 0 | 17115 | gtex_brain_ba24 |
| rs8113388 | 19 | 52375239 | ZNF577 | ENSG00000161551.8 | 1.097E-9 | 0 | 15994 | gtex_brain_ba24 |
| rs1055408 | 19 | 52375424 | ZNF577 | ENSG00000161551.8 | 2.725E-9 | 0 | 15809 | gtex_brain_ba24 |
| rs2288868 | 19 | 52376507 | ZNF577 | ENSG00000161551.8 | 1.097E-9 | 0 | 14726 | gtex_brain_ba24 |
| rs8107969 | 19 | 52376952 | ZNF577 | ENSG00000161551.8 | 2.669E-9 | 0 | 14281 | gtex_brain_ba24 |
| rs60088244 | 19 | 52401444 | ZNF577 | ENSG00000161551.8 | 8.259E-8 | 0 | -10211 | gtex_brain_ba24 |
| rs55633023 | 19 | 52402357 | ZNF577 | ENSG00000161551.8 | 8.259E-8 | 0 | -11124 | gtex_brain_ba24 |
| rs8111274 | 19 | 52304593 | ZNF577 | ENSG00000161551.8 | 8.15E-7 | 0 | 86640 | gtex_brain_putamen_basal |
| rs73063025 | 19 | 52349512 | ZNF577 | ENSG00000161551.8 | 1.356E-6 | 0 | 41721 | gtex_brain_putamen_basal |
| rs7252002 | 19 | 52351993 | ZNF577 | ENSG00000161551.8 | 1.111E-7 | 0 | 39240 | gtex_brain_putamen_basal |
| rs7252006 | 19 | 52352006 | ZNF577 | ENSG00000161551.8 | 6.325E-9 | 0 | 39227 | gtex_brain_putamen_basal |
| rs7252110 | 19 | 52352015 | ZNF577 | ENSG00000161551.8 | 6.325E-9 | 0 | 39218 | gtex_brain_putamen_basal |
| rs7252849 | 19 | 52352440 | ZNF577 | ENSG00000161551.8 | 4.154E-7 | 0 | 38793 | gtex_brain_putamen_basal |
| rs10421731 | 19 | 52353109 | ZNF577 | ENSG00000161551.8 | 2.241E-7 | 0 | 38124 | gtex_brain_putamen_basal |
| rs7256792 | 19 | 52353249 | ZNF577 | ENSG00000161551.8 | 2.069E-7 | 0 | 37984 | gtex_brain_putamen_basal |
| rs6509575 | 19 | 52353437 | ZNF577 | ENSG00000161551.8 | 7.466E-10 | 0 | 37796 | gtex_brain_putamen_basal |
| rs2191669 | 19 | 52353761 | ZNF577 | ENSG00000161551.8 | 1.915E-9 | 0 | 37472 | gtex_brain_putamen_basal |
| rs2215518 | 19 | 52353805 | ZNF577 | ENSG00000161551.8 | 1.933E-9 | 0 | 37428 | gtex_brain_putamen_basal |
| rs13382098 | 19 | 52354381 | ZNF577 | ENSG00000161551.8 | 2.758E-9 | 0 | 36852 | gtex_brain_putamen_basal |
| rs7249718 | 19 | 52354972 | ZNF577 | ENSG00000161551.8 | 1.331E-9 | 0 | 36261 | gtex_brain_putamen_basal |
| rs10409522 | 19 | 52355333 | ZNF577 | ENSG00000161551.8 | 1.21E-9 | 0 | 35900 | gtex_brain_putamen_basal |
| rs397966537 | 19 | 52355856 | ZNF577 | ENSG00000161551.8 | 3.048E-10 | 0 | 35377 | gtex_brain_putamen_basal |
| rs7255208 | 19 | 52356135 | ZNF577 | ENSG00000161551.8 | 1.023E-9 | 0 | 35098 | gtex_brain_putamen_basal |
| rs74651958 | 19 | 52356623 | ZNF577 | ENSG00000161551.8 | 2.449E-8 | 0 | 34610 | gtex_brain_putamen_basal |
| rs7256036 | 19 | 52356791 | ZNF577 | ENSG00000161551.8 | 2.57E-7 | 0 | 34442 | gtex_brain_putamen_basal |
| rs10424176 | 19 | 52357178 | ZNF577 | ENSG00000161551.8 | 1.044 e-9 | 0 | 34055 | gtex_brain_putamen_basal |
| rs10423844 | 19 | 52357203 | ZNF577 | ENSG00000161551.8 | 1.044 e-9 | 0 | 34030 | gtex_brain_putamen_basal |
| rs56406030 | 19 | 52357458 | ZNF577 | ENSG00000161551.8 | 8.689E-8 | 0 | 33775 | gtex_brain_putamen_basal |
| rs10424471 | 19 | 52357472 | ZNF577 | ENSG00000161551.8 | 7.562E-10 | 0 | 33761 | gtex_brain_putamen_basal |
| rs112952722 | 19 | 52357738 | ZNF577 | ENSG00000161551.8 | 1.125E-7 | 0 | 33495 | gtex_brain_putamen_basal |
| rs11883265 | 19 | 52357777 | ZNF577 | ENSG00000161551.8 | 1.116E-9 | 0 | 33456 | gtex_brain_putamen_basal |
| rs11883230 | 19 | 52357805 | ZNF577 | ENSG00000161551.8 | 1.064E-9 | 0 | 33428 | gtex_brain_putamen_basal |
| rs6509576 | 19 | 52358023 | ZNF577 | ENSG00000161551.8 | 9.173E-10 | 0 | 33210 | gtex_brain_putamen_basal |
| rs6509577 | 19 | 52358119 | ZNF577 | ENSG00000161551.8 | 1.077E-9 | 0 | 33114 | gtex_brain_putamen_basal |
| rs8102206 | 19 | 52358269 | ZNF577 | ENSG00000161551.8 | 1.082E-9 | 0 | 32964 | gtex_brain_putamen_basal |
| rs34540338 | 19 | 52358593 | ZNF577 | ENSG00000161551.8 | 2.201E-9 | 0 | 32640 | gtex_brain_putamen_basal |
| rs1056294 | 19 | 52359169 | ZNF577 | ENSG00000161551.8 | 1.023E-9 | 0 | 32064 | gtex_brain_putamen_basal |
| rs11671807 | 19 | 52359502 | ZNF577 | ENSG00000161551.8 | 2.306E-9 | 0 | 31731 | gtex_brain_putamen_basal |
| rs7253396 | 19 | 52359605 | ZNF577 | ENSG00000161551.8 | 1.311E-9 | 0 | 31628 | gtex_brain_putamen_basal |
| rs3752124 | 19 | 52359868 | ZNF577 | ENSG00000161551.8 | 1.459E-9 | 0 | 31365 | gtex_brain_putamen_basal |
| rs7255924 | 19 | 52359874 | ZNF577 | ENSG00000161551.8 | 1.463E-9 | 0 | 31359 | gtex_brain_putamen_basal |
| rs3752123 | 19 | 52359983 | ZNF577 | ENSG00000161551.8 | 2.306E-9 | 0 | 31250 | gtex_brain_putamen_basal |
| rs3752122 | 19 | 52360097 | ZNF577 | ENSG00000161551.8 | 1.608E-9 | 0 | 31136 | gtex_brain_putamen_basal |
| rs3752121 | 19 | 52360112 | ZNF577 | ENSG00000161551.8 | 2.306E-9 | 0 | 31121 | gtex_brain_putamen_basal |
| rs397950142 | 19 | 52360193 | ZNF577 | ENSG00000161551.8 | 1.603E-9 | 0 | 31040 | gtex_brain_putamen_basal |
| rs6509578 | 19 | 52360278 | ZNF577 | ENSG00000161551.8 | 1.738E-9 | 0 | 30955 | gtex_brain_putamen_basal |
| rs6509579 | 19 | 52360441 | ZNF577 | ENSG00000161551.8 | 1.866E-9 | 0 | 30792 | gtex_brain_putamen_basal |
| rs6509580 | 19 | 52360518 | ZNF577 | ENSG00000161551.8 | 1.931E-9 | 0 | 30715 | gtex_brain_putamen_basal |
| rs10642180 | 19 | 52360586 | ZNF577 | ENSG00000161551.8 | 1.726E-9 | 0 | 30647 | gtex_brain_putamen_basal |
| rs200930484 | 19 | 52360610 | ZNF577 | ENSG00000161551.8 | 1.817E-8 | 0 | 30623 | gtex_brain_putamen_basal |
| rs201458902 | 19 | 52360677 | ZNF577 | ENSG00000161551.8 | 5.803E-7 | 0 | 30556 | gtex_brain_putamen_basal |
| rs11665778 | 19 | 52360813 | ZNF577 | ENSG00000161551.8 | 2.211E-9 | 0 | 30420 | gtex_brain_putamen_basal |
| rs11669509 | 19 | 52360842 | ZNF577 | ENSG00000161551.8 | 2.235E-9 | 0 | 30391 | gtex_brain_putamen_basal |
| rs765010 | 19 | 52361358 | ZNF577 | ENSG00000161551.8 | 2.85E-9 | 0 | 29875 | gtex_brain_putamen_basal |
| rs765009 | 19 | 52361834 | ZNF577 | ENSG00000161551.8 | 3.581E-9 | 0 | 29399 | gtex_brain_putamen_basal |
| rs11672786 | 19 | 52361981 | ZNF577 | ENSG00000161551.8 | 2.423E-9 | 0 | 29252 | gtex_brain_putamen_basal |
| rs62107503 | 19 | 52362158 | ZNF577 | ENSG00000161551.8 | 1.125E-7 | 0 | 29075 | gtex_brain_putamen_basal |
| rs200979439 | 19 | 52364546 | ZNF577 | ENSG00000161551.8 | 3.905E-7 | 0 | 26687 | gtex_brain_putamen_basal |
| rs8113216 | 19 | 52366691 | ZNF577 | ENSG00000161551.8 | 2.57E-7 | 0 | 24542 | gtex_brain_putamen_basal |
| rs8100840 | 19 | 52370512 | ZNF577 | ENSG00000161551.8 | 1.114E-7 | 0 | 20721 | gtex_brain_putamen_basal |
| rs10408912 | 19 | 52370845 | ZNF577 | ENSG00000161551.8 | 4.22E-7 | 0 | 20388 | gtex_brain_putamen_basal |
| rs7251070 | 19 | 52371797 | ZNF577 | ENSG00000161551.8 | 1.051E-7 | 0 | 19436 | gtex_brain_putamen_basal |
| rs6509585 | 19 | 52374118 | ZNF577 | ENSG00000161551.8 | 3.095E-8 | 0 | 17115 | gtex_brain_putamen_basal |
| rs8113388 | 19 | 52375239 | ZNF577 | ENSG00000161551.8 | 3.095E-8 | 0 | 15994 | gtex_brain_putamen_basal |
| rs1055408 | 19 | 52375424 | ZNF577 | ENSG00000161551.8 | 3.095E-8 | 0 | 15809 | gtex_brain_putamen_basal |
| rs2288868 | 19 | 52376507 | ZNF577 | ENSG00000161551.8 | 3.095E-8 | 0 | 14726 | gtex_brain_putamen_basal |
| rs8107969 | 19 | 52376952 | ZNF577 | ENSG00000161551.8 | 3.103E-8 | 0 | 14281 | gtex_brain_putamen_basal |
| rs112699281 | 19 | 52412001 | ZNF577 | ENSG00000161551.8 | 1.623E-6 | 0 | -20768 | gtex_brain_putamen_basal |
| rs8103682 | 19 | 52480037 | ZNF577 | ENSG00000161551.8 | 6.725E-7 | 0 | -88804 | gtex_brain_putamen_basal |
| rs8102072 | 19 | 52488711 | ZNF577 | ENSG00000161551.8 | 1.361E-6 | 0 | -97478 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
创eral gene expression (GTEx)
创e expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME GENERIC TRANSCRIPTION PATHWAY | 352 | 181 | All SZGR 2.0 genes in this pathway |
| OUILLETTE CLL 13Q14 DELETION UP | 74 | 40 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP | 397 | 206 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |