Gene Page:HIRIP3

Summary?
GeneID 8479
Symbol HIRIP3
Synonyms -
Description HIRA interacting protein 3
Reference MIM:603365|HGNC:HGNC:4917|Ensembl:ENSG00000149929|HPRD:04531|Vega:OTTHUMG00000132118
Gene type protein-coding
Map location 16p11.2
Pascal p-value 2.515E-9
Sherlock p-value 0.081
Fetal beta 0.141
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CNV:YES Copy number variation studies Manual curation
CV:PGCnp Genome-wide Association Study GWAS
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01775

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg05995267 16 29822529 HIRIP3 7.949E-4 4.713 DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KBTBD7 0.97 0.97
SCYL2 0.96 0.97
WDR82 0.96 0.96
KBTBD6 0.96 0.96
RBMXL1 0.96 0.95
ASB7 0.95 0.95
ZMYM4 0.95 0.97
SPAST 0.95 0.96
GRPEL2 0.95 0.95
C5orf24 0.95 0.96
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FXYD1 -0.74 -0.87
MT-CO2 -0.73 -0.87
AF347015.31 -0.72 -0.85
AIFM3 -0.72 -0.77
AF347015.33 -0.72 -0.84
AF347015.27 -0.72 -0.84
AF347015.8 -0.71 -0.87
HSD17B14 -0.71 -0.79
S100B -0.71 -0.81
MT-CYB -0.71 -0.84

Section III. Gene Ontology annotation

Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006333 chromatin assembly or disassembly TAS 9710638
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus TAS 9710638

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS 138 91 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL SHORT TERM 32 15 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL UP 45 26 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA VIA VHL 34 24 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403 240 All SZGR 2.0 genes in this pathway