基因页：TMEM25
Summary？
| 基因 | 84866 |
| 象征 | TMEM25 |
| 同义词 | - |
| 描述 | 跨膜蛋白25 |
| Reference | MIM：613934|HGNC：HGNC：25890|ENSEMBL：ENSG00000149582|HPRD:11635|Vega：Otthumg00000166339 |
| 基因类型 | 蛋白质编码 |
| 地图位置 | 11q23.3 |
| Pascal P值 | 0.011 |
| Sherlock p-value | 0.63 |
| 主持人 | 前扣带回皮层BA24 小脑半球 小脑 皮质 元 |
Gene in Data Sources
| 基因集名称 | 基因组方法 | 描述 | 信息 |
|---|---|---|---|
| 简历：PGCNP | 全基因组协会研究 | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.006 |
Section I. Genetics and epigenetics annotation
EQTL注释
EQTL注释| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | PVALUE | QVALUE | TSS距离 | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| RS12289253 | 11 | 118405068 | TMEM25 | ENSG00000149582.11 | 5.068E-8 | 0 | 2995 | gtex_brain_ba24 |
| RS45505501 | 11 | 118405305 | TMEM25 | ENSG00000149582.11 | 5.947E-8 | 0 | 3232 | gtex_brain_ba24 |
| RS45485302 | 11 | 118405377 | TMEM25 | ENSG00000149582.11 | 6.006e-8 | 0 | 3304 | gtex_brain_ba24 |
| RS45548238 | 11 | 118405437 | TMEM25 | ENSG00000149582.11 | 9.845e-7 | 0 | 3364 | gtex_brain_ba24 |
| RS45522239 | 11 | 118405438 | TMEM25 | ENSG00000149582.11 | 5.96E-8 | 0 | 3365 | gtex_brain_ba24 |
| rs45474901 | 11 | 118405453 | TMEM25 | ENSG00000149582.11 | 4.148e-7 | 0 | 3380 | gtex_brain_ba24 |
| rs3741323 | 11 | 118405641 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 3568 | gtex_brain_ba24 |
| rs3741324 | 11 | 118405835 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 3762 | gtex_brain_ba24 |
| RS45576832 | 11 | 118406328 | TMEM25 | ENSG00000149582.11 | 1.756E-6 | 0 | 4255 | gtex_brain_ba24 |
| RS59533931 | 11 | 118407070 | TMEM25 | ENSG00000149582.11 | 4.895e-8 | 0 | 4997 | gtex_brain_ba24 |
| RS7108845 | 11 | 118407523 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 5450 | gtex_brain_ba24 |
| RS535207 | 11 | 118408033 | TMEM25 | ENSG00000149582.11 | 5.068E-8 | 0 | 5960 | gtex_brain_ba24 |
| RS75802917 | 11 | 118408339 | TMEM25 | ENSG00000149582.11 | 5.044e-8 | 0 | 6266 | gtex_brain_ba24 |
| RS73022038 | 11 | 118408471 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 6398 | gtex_brain_ba24 |
| rs74404016 | 11 | 118408653 | TMEM25 | ENSG00000149582.11 | 5.061E-8 | 0 | 6580 | gtex_brain_ba24 |
| RS73022041 | 11 | 118408789 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 6716 | gtex_brain_ba24 |
| RS73022042 | 11 | 118408893 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 6820 | gtex_brain_ba24 |
| RS7128587 | 11 | 118409302 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 7229 | gtex_brain_ba24 |
| RS7131631 | 11 | 118409374 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 7301 | gtex_brain_ba24 |
| RS11216880 | 11 | 118409536 | TMEM25 | ENSG00000149582.11 | 4.423e-8 | 0 | 7463 | gtex_brain_ba24 |
| RS11216881 | 11 | 118409539 | TMEM25 | ENSG00000149582.11 | 4.438e-8 | 0 | 7466 | gtex_brain_ba24 |
| RS7101585 | 11 | 118409583 | TMEM25 | ENSG00000149582.11 | 4.643E-8 | 0 | 7510 | gtex_brain_ba24 |
| RS11216883 | 11 | 118410468 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 8395 | gtex_brain_ba24 |
| RS11216884 | 11 | 118410488 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 8415 | gtex_brain_ba24 |
| RS11216885 | 11 | 118410545 | TMEM25 | ENSG00000149582.11 | 4.753E-8 | 0 | 8472 | gtex_brain_ba24 |
| RS11216886 | 11 | 118411424 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 9351 | gtex_brain_ba24 |
| RS7932700 | 11 | 118411713 | TMEM25 | ENSG00000149582.11 | 5.094E-8 | 0 | 9640 | gtex_brain_ba24 |
| rs60067274 | 11 | 118412296 | TMEM25 | ENSG00000149582.11 | 4.672E-8 | 0 | 10223 | gtex_brain_ba24 |
| rs61290697 | 11 | 118412358 | TMEM25 | ENSG00000149582.11 | 5.265E-8 | 0 | 10285 | gtex_brain_ba24 |
| rs58270621 | 11 | 118413604 | TMEM25 | ENSG00000149582.11 | 4.522e-7 | 0 | 11531 | gtex_brain_ba24 |
| rs3741320 | 11 | 118415847 | TMEM25 | ENSG00000149582.11 | 5.661E-8 | 0 | 13774 | gtex_brain_ba24 |
| rs3741319 | 11 | 118415848 | TMEM25 | ENSG00000149582.11 | 5.661E-8 | 0 | 13775 | gtex_brain_ba24 |
| RS3825055 | 11 | 118416073 | TMEM25 | ENSG00000149582.11 | 5.382E-7 | 0 | 14000 | gtex_brain_ba24 |
| RS2277295 | 11 | 118416253 | TMEM25 | ENSG00000149582.11 | 4.134E-7 | 0 | 14180 | gtex_brain_ba24 |
| rs143059106 | 11 | 118417645 | TMEM25 | ENSG00000149582.11 | 4.69E-7 | 0 | 15572 | gtex_brain_ba24 |
| RS45536433 | 11 | 118417648 | TMEM25 | ENSG00000149582.11 | 7.969E-7 | 0 | 15575 | gtex_brain_ba24 |
| RS59176377 | 11 | 118419295 | TMEM25 | ENSG00000149582.11 | 9.551E-7 | 0 | 17222 | gtex_brain_ba24 |
| RS113739713 | 11 | 118420101 | TMEM25 | ENSG00000149582.11 | 4.364E-7 | 0 | 18028 | gtex_brain_ba24 |
| RS11216887 | 11 | 118420736 | TMEM25 | ENSG00000149582.11 | 4.556E-7 | 0 | 18663 | gtex_brain_ba24 |
| RS11216890 | 11 | 118421569 | TMEM25 | ENSG00000149582.11 | 2.429E-6 | 0 | 19496年 | gtex_brain_ba24 |
| RS11216891 | 11 | 118422234 | TMEM25 | ENSG00000149582.11 | 1.756E-6 | 0 | 20161 | gtex_brain_ba24 |
| RS2277293 | 11 | 118422868 | TMEM25 | ENSG00000149582.11 | 4.337E-7 | 0 | 20795 | gtex_brain_ba24 |
| RS11216892 | 11 | 118424008 | TMEM25 | ENSG00000149582.11 | 4.377E-7 | 0 | 21935 | gtex_brain_ba24 |
| RS56403966 | 11 | 118425051 | TMEM25 | ENSG00000149582.11 | 2.214E-6 | 0 | 22978 | gtex_brain_ba24 |
| RS55857590 | 11 | 118425063 | TMEM25 | ENSG00000149582.11 | 4.351E-7 | 0 | 22990 | gtex_brain_ba24 |
| RS2277292 | 11 | 118425419 | TMEM25 | ENSG00000149582.11 | 4.692E-7 | 0 | 23346 | gtex_brain_ba24 |
| RS7929887 | 11 | 118428791 | TMEM25 | ENSG00000149582.11 | 4.478E-7 | 0 | 26718 | gtex_brain_ba24 |
| RS201228166 | 11 | 118428828 | TMEM25 | ENSG00000149582.11 | 4.722E-7 | 0 | 26755 | gtex_brain_ba24 |
| rs111942423 | 11 | 118429764 | TMEM25 | ENSG00000149582.11 | 4.478E-7 | 0 | 27691 | gtex_brain_ba24 |
| RS11216896 | 11 | 118430048 | TMEM25 | ENSG00000149582.11 | 4.478E-7 | 0 | 27975 | gtex_brain_ba24 |
| RS11552421 | 11 | 118430519 | TMEM25 | ENSG00000149582.11 | 4.286E-7 | 0 | 28446 | gtex_brain_ba24 |
| RS56693362 | 11 | 118430773 | TMEM25 | ENSG00000149582.11 | 1.038E-6 | 0 | 28700 | gtex_brain_ba24 |
| RS11216897 | 11 | 118432279 | TMEM25 | ENSG00000149582.11 | 1.629E-7 | 0 | 30206 | gtex_brain_ba24 |
| RS4326835 | 11 | 118432404 | TMEM25 | ENSG00000149582.11 | 1.032E-6 | 0 | 30331 | gtex_brain_ba24 |
| RS11216898 | 11 | 118432852 | TMEM25 | ENSG00000149582.11 | 1.379E-7 | 0 | 30779 | gtex_brain_ba24 |
| RS200984057 | 11 | 118433259 | TMEM25 | ENSG00000149582.11 | 3.372E-8 | 0 | 31186 | gtex_brain_ba24 |
| rs59108310 | 11 | 118433729 | TMEM25 | ENSG00000149582.11 | 3.349e-8 | 0 | 31656 | gtex_brain_ba24 |
| RS11216899 | 11 | 118434421 | TMEM25 | ENSG00000149582.11 | 1.954E-7 | 0 | 32348 | gtex_brain_ba24 |
| RS60753148 | 11 | 118434835 | TMEM25 | ENSG00000149582.11 | 1.894E-7 | 0 | 32762 | gtex_brain_ba24 |
| RS2277291 | 11 | 118435756 | TMEM25 | ENSG00000149582.11 | 7.251E-7 | 0 | 33683 | gtex_brain_ba24 |
| rs11216900 | 11 | 118436079 | TMEM25 | ENSG00000149582.11 | 3.502E-8 | 0 | 34006 | gtex_brain_ba24 |
| rs11216902 | 11 | 118437279 | TMEM25 | ENSG00000149582.11 | 3.377E-8 | 0 | 35206 | gtex_brain_ba24 |
| RS60837962 | 11 | 118438448 | TMEM25 | ENSG00000149582.11 | 6.631E-7 | 0 | 36375 | gtex_brain_ba24 |
| RS12224844 | 11 | 118439048 | TMEM25 | ENSG00000149582.11 | 3.323e-8 | 0 | 36975 | gtex_brain_ba24 |
| rs11216904 | 11 | 118440863 | TMEM25 | ENSG00000149582.11 | 3.317E-8 | 0 | 38790 | gtex_brain_ba24 |
| RS10892243 | 11 | 118441846 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 39773 | gtex_brain_ba24 |
| rs11216905 | 11 | 118442577 | TMEM25 | ENSG00000149582.11 | 1.613E-7 | 0 | 40504 | gtex_brain_ba24 |
| rs11216906 | 11 | 118443944 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 41871 | gtex_brain_ba24 |
| rs11216907 | 11 | 118444525 | TMEM25 | ENSG00000149582.11 | 1.773E-7 | 0 | 42452 | gtex_brain_ba24 |
| RS17122269 | 11 | 118445275 | TMEM25 | ENSG00000149582.11 | 7.251E-7 | 0 | 43202 | gtex_brain_ba24 |
| rs73023341 | 11 | 118445585 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 43512 | gtex_brain_ba24 |
| RS55844025 | 11 | 118446298 | TMEM25 | ENSG00000149582.11 | 3.302E-7 | 0 | 44225 | gtex_brain_ba24 |
| RS9736327 | 11 | 118447580 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 45507 | gtex_brain_ba24 |
| RS9735421 | 11 | 118447597 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 45524 | gtex_brain_ba24 |
| RS9735449 | 11 | 118448087 | TMEM25 | ENSG00000149582.11 | 3.823e-7 | 0 | 46014 | gtex_brain_ba24 |
| RS17122278 | 11 | 118449370 | TMEM25 | ENSG00000149582.11 | 5.959E-7 | 0 | 47297 | gtex_brain_ba24 |
| RS73023350 | 11 | 118449396 | TMEM25 | ENSG00000149582.11 | 3.317E-8 | 0 | 47323 | gtex_brain_ba24 |
| rs11216909 | 11 | 118449746 | TMEM25 | ENSG00000149582.11 | 3.283E-9 | 0 | 47673 | gtex_brain_ba24 |
| rs11216910 | 11 | 118450046 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 47973 | gtex_brain_ba24 |
| rs7122547 | 11 | 118450260 | TMEM25 | ENSG00000149582.11 | 1.215E-7 | 0 | 48187 | gtex_brain_ba24 |
| RS7126175 | 11 | 118450875 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 48802 | gtex_brain_ba24 |
| rs11216911 | 11 | 118451901 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 49828 | gtex_brain_ba24 |
| rs11216912 | 11 | 118452334 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 50261 | gtex_brain_ba24 |
| RS60112336 | 11 | 118453483 | TMEM25 | ENSG00000149582.11 | 3.841E-7 | 0 | 51410 | gtex_brain_ba24 |
| rs11216913 | 11 | 118453681 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 51608 | gtex_brain_ba24 |
| RS17842763 | 11 | 118454177 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 52104 | gtex_brain_ba24 |
| rs11216914 | 11 | 118456414 | TMEM25 | ENSG00000149582.11 | 9.198E-8 | 0 | 54341 | gtex_brain_ba24 |
| RS17092756 | 11 | 118457630 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 55557 | gtex_brain_ba24 |
| RS57438673 | 11 | 118459039 | TMEM25 | ENSG00000149582.11 | 1.773E-7 | 0 | 56966 | gtex_brain_ba24 |
| RS113054880 | 11 | 118459702 | TMEM25 | ENSG00000149582.11 | 1.584E-7 | 0 | 57629 | gtex_brain_ba24 |
| rs11216916 | 11 | 118461605 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 59532 | gtex_brain_ba24 |
| rs11216917 | 11 | 118462160 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 60087 | gtex_brain_ba24 |
| rs11216921 | 11 | 118464815 | TMEM25 | ENSG00000149582.11 | 1.945E-7 | 0 | 62742 | gtex_brain_ba24 |
| rs11216922 | 11 | 118465295 | TMEM25 | ENSG00000149582.11 | 3.541E-8 | 0 | 63222 | gtex_brain_ba24 |
| rs11216923 | 11 | 118465501 | TMEM25 | ENSG00000149582.11 | 3.541E-8 | 0 | 63428 | gtex_brain_ba24 |
| RS7115634 | 11 | 118466249 | TMEM25 | ENSG00000149582.11 | 4.489E-7 | 0 | 64176 | gtex_brain_ba24 |
| RS7931564 | 11 | 118469571 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 67498 | gtex_brain_ba24 |
| rs11216924 | 11 | 118470092 | TMEM25 | ENSG00000149582.11 | 4.489E-7 | 0 | 68019 | gtex_brain_ba24 |
| rs11216925 | 11 | 118471423 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 69350 | gtex_brain_ba24 |
| rs11216926 | 11 | 118471996 | TMEM25 | ENSG00000149582.11 | 4.489E-7 | 0 | 69923 | gtex_brain_ba24 |
| RS10892245 | 11 | 118472354 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 70281 | gtex_brain_ba24 |
| RS1047079 | 11 | 118473231 | TMEM25 | ENSG00000149582.11 | 7.251E-7 | 0 | 71158 | gtex_brain_ba24 |
| RS17742 | 11 | 118473385 | TMEM25 | ENSG00000149582.11 | 3.314e-8 | 0 | 71312 | gtex_brain_ba24 |
| RS375152863 | 11 | 118474719 | TMEM25 | ENSG00000149582.11 | 3.568E-6 | 0 | 72646 | gtex_brain_ba24 |
第二节。转录组注释
一般基因表达（GTEX）
时间变化的基因表达（brainspan）
Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
No co-expressed genes in brain regions
第三节。基因本体论注释
| 细胞分量 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| 去：0005576 | 细胞外区域 | IEA | - | |
| GO：0016021 | 膜不可或缺 | IEA | - | |
| 去：0005886 | 质膜 | IEA | - |
Section V. Pathway annotation
| 路径名 | 路径大小 | # SZGR 2.0基因通路 | 信息 |
|---|---|---|---|
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821年 | 933 | All SZGR 2.0 genes in this pathway |
| 甲状腺癌变性DN | 537 | 339 | All SZGR 2.0 genes in this pathway |
| lastowska神经母细胞瘤副本编号dn | 800 | 473 | All SZGR 2.0 genes in this pathway |
| LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL DN | 114 | 58 | All SZGR 2.0 genes in this pathway |
| VANASSE BCL2靶向DN | 74 | 50 | All SZGR 2.0 genes in this pathway |
| Ivanovska mir106b目标 | 90 | 56 | All SZGR 2.0 genes in this pathway |
| CTBP1的Purbey目标不是SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |
| Fortschegger PHF8靶向DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
第六节。microRNA注释
| mirna家族 | 目标位置 | miRNA ID | mirna seq | ||
|---|---|---|---|---|---|
| UTR开始 | UTR结束 | 匹配方法 | |||
| mir-103/107 | 568 | 574 | 1a | hsa-miR-103brain | agcagcauuguacggcuauga |
| hsa-miR-107brain | agcagcauuguacgggcuauca | ||||
| miR-128 | 882 | 889 | 1A，M8 | hsa-miR-128a | ucacagugaaccggucuuuu |
| hsa-miR-128b | ucacagugaaccggucuuc | ||||
| mir-218 | 550 | 557 | 1A，M8 | hsa-miR-218brain | UUGUGCUUGAUCUAACCAUGU |
| hsa-miR-218brain | UUGUGCUUGAUCUAACCAUGU | ||||
| hsa-miR-218brain | UUGUGCUUGAUCUAACCAUGU | ||||
| mir-27 | 883 | 889 | M8 | HSA-MIR-27Abrain | uucacaguggcuaaguuccgc |
| HSA-MIR-27Bbrain | uucacaguggcuaaguucugc | ||||
| mir-320 | 1042 | 1048 | 1a | hsa-miR-320 | aaaagcugggugagaggggcgaa |