Gene Page:PPFIA1

Summary?
GeneID 8500
Symbol PPFIA1
Synonyms LIP.1|LIP1|LIPRIN
Description PTPRF interacting protein alpha 1
Reference MIM:611054|HGNC:HGNC:9245|Ensembl:ENSG00000131626|HPRD:11451|Vega:OTTHUMG00000167266
Gene type protein-coding
Map location 11q13.3
Pascal p-value 0.413
Sherlock p-value 0.491
Fetal beta -0.135
DMG 1 (# studies)
eGene Cerebellar Hemisphere
Cerebellum
Cortex
Myers' cis & trans
Support PROTEIN CLUSTERING
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
CompositeSet
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg12652780 11 70178166 PPFIA1 3.466E-4 0.339 0.041 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
snp_a-1817904 0 PPFIA1 8500 0.06 trans
rs6494052 chr15 59295924 PPFIA1 8500 0.19 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception凌晨ks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GPI 0.86 0.83
FAM73B 0.85 0.82
TOM1 0.85 0.85
LIMK1 0.85 0.82
SNPH 0.84 0.87
ABHD12 0.84 0.82
TOM1L2 0.84 0.83
SRPR 0.84 0.83
NDRG4 0.83 0.84
ACO2 0.83 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FAM159B -0.44 -0.67
C9orf46 -0.42 -0.45
EXOSC8 -0.41 -0.37
RPL13AP22 -0.41 -0.56
FAM36A -0.40 -0.36
AC005921.3 -0.40 -0.43
AC087071.1 -0.40 -0.38
RP9P -0.40 -0.46
AC120053.1 -0.39 -0.42
RBMX2 -0.39 -0.37

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ERC1 Cast2 | ELKS | KIAA1081 | MGC12974 | RAB6IP2 ELKS/RAB6-interacting/CAST family member 1 - HPRD 12923177
ERC2 CAST | CAST1 | ELKSL | KIAA0378 | MGC133063 | MGC133064 | SPBC110 | Spc110 ELKS/RAB6-interacting/CAST family member 2 Liprin-alpha1 interacts with ERC2. BIND 12923177
ERC2 CAST | CAST1 | ELKSL | KIAA0378 | MGC133063 | MGC133064 | SPBC110 | Spc110 ELKS/RAB6-interacting/CAST family member 2 - HPRD,BioGRID 12923177
GIT1 - G protein-coupled receptor kinase interacting ArfGAP 1 Liprin-alpha1 interacts with GIT1. This interaction was modeled on a demonstrated interaction between human liprin-alpha1 and rat GIT1. BIND 12923177
GIT1 - G protein-coupled receptor kinase interacting ArfGAP 1 - HPRD,BioGRID 12629171
GRIP2 - glutamate receptor interacting protein 2 Affinity Capture-Western BioGRID 12629171|12923177
MBIP - MAP3K12 binding inhibitory protein 1 Two-hybrid BioGRID 16189514
NCOA2 GRIP1 | KAT13C | MGC138808 | NCoA-2 | TIF2 nuclear receptor coactivator 2 - HPRD,BioGRID 11931740
PPFIA2 FLJ41378 | MGC132572 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 - HPRD,BioGRID 9624153
PPFIA3 KIAA0654 | LPNA3 | MGC126567 | MGC126569 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 - HPRD,BioGRID 9624153
PPFIBP1 L2 | hSGT2 | hSgt2p PTPRF interacting protein, binding protein 1 (liprin beta 1) - HPRD,BioGRID 9624153
PPFIBP2 Cclp1 | DKFZp781K06126 | MGC42541 PTPRF interacting protein, binding protein 2 (liprin beta 2) - HPRD,BioGRID 9624153
PPP2CA PP2Ac | PP2CA | RP-C protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Affinity Capture-MS BioGRID 18782753
PPP2R1A MGC786 | PR65A protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform Affinity Capture-MS BioGRID 18782753
PPP2R5D B56D | MGC2134 | MGC8949 protein phosphatase 2, regulatory subunit B', delta isoform Affinity Capture-Western
Two-hybrid		 BioGRID 16189514
PTPRC B220 | CD45 | CD45R | GP180 | LCA | LY5 | T200 protein tyrosine phosphatase, receptor type, C - HPRD,BioGRID 9624153
PTPRD HPTP | HPTP-DELTA | HPTPD | MGC119750 | MGC119751 | MGC119752 | MGC119753 | PTPD | R-PTP-DELTA protein tyrosine phosphatase, receptor type, D - HPRD,BioGRID 8524829
PTPRF FLJ43335 | FLJ45062 | FLJ45567 | LAR protein tyrosine phosphatase, receptor type, F - HPRD 8524829|9624153
PTPRF FLJ43335 | FLJ45062 | FLJ45567 | LAR protein tyrosine phosphatase, receptor type, F - HPRD,BioGRID 7796809|8524829
|9624153|8524829|9624153
PTPRS PTPSIGMA protein tyrosine phosphatase, receptor type, S - HPRD,BioGRID 8524829
TNNT1 ANM | FLJ98147 | MGC104241 | STNT | TNT | TNTS troponin T type 1 (skeletal, slow) Two-hybrid BioGRID 16189514


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
LIU SOX4 TARGETS DN 309 191 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352 225 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 2HR DN 88 53 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
JAERVINEN AMPLIFIED IN LARYNGEAL CANCER 40 24 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514 319 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214 139 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON 158 93 All SZGR 2.0 genes in this pathway
DING LUNG CANCER EXPRESSION BY COPY NUMBER 100 62 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225 163 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225 139 All SZGR 2.0 genes in this pathway
SU TESTIS 76 53 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD DN 150 93 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 105 73 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY DN 145 88 All SZGR 2.0 genes in this pathway
KIM GASTRIC CANCER CHEMOSENSITIVITY 103 64 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156 101 All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262 186 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178 111 All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 All SZGR 2.0 genes in this pathway
CROMER TUMORIGENESIS UP 63 36 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA 43 27 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS UP 74 45 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP 116 87 All SZGR 2.0 genes in this pathway