Gene Page:PIK3R3

Summary?
GeneID 8503
Symbol PIK3R3
Synonyms p55|p55-GAMMA|p55PIK
Description phosphoinositide-3-kinase regulatory subunit 3
Reference MIM:606076|HGNC:HGNC:8981|Ensembl:ENSG00000117461|HPRD:05831|Vega:OTTHUMG00000008096
Gene type protein-coding
Map location 1p34.1
Pascal p-value 0.605
Fetal beta 1.06
Support CompositeSet

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Fromer_2014 Whole Exome Sequencing analysis This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0149

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
PIK3R3 chr1 46512257 C T NM_001114172
NM_003629		 p.328V>I
p.328V>I		 missense
missense		 Schizophrenia DNM:Fromer_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PPARD 0.72 0.74
FBXO10 0.72 0.74
COG1 0.72 0.68
SGSM2 0.71 0.72
TRIM9 0.70 0.73
KAT2A 0.70 0.68
AC008806.1 0.70 0.72
GORASP1 0.70 0.67
RAB36 0.70 0.71
WDR42A 0.70 0.70
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.56 -0.38
AF347015.31 -0.44 -0.32
MT-CO2 -0.43 -0.31
AF347015.18 -0.43 -0.28
IL32 -0.43 -0.30
GNG11 -0.43 -0.34
AF347015.8 -0.42 -0.28
FAM159B -0.42 -0.48
C1orf54 -0.42 -0.34
MT-CYB -0.41 -0.27

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005515 protein binding IEA -
GO:0005515 protein binding 新闻学会 8647200
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS 9524259
GO:0016301 kinase activity IEA -
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008286 insulin receptor signaling pathway IEA -
GO:0008286 insulin receptor signaling pathway TAS 9524259
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm IDA 18029348
GO:0005942 phosphoinositide 3-kinase complex IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG ERBB SIGNALING PATHWAY 87 71 All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 76 56 All SZGR 2.0 genes in this pathway
KEGG MTOR SIGNALING PATHWAY 52 40 All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS 88 62 All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 76 53 All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201 138 All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 102 88 All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155 105 All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY 75 56 All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY 79 58 All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 97 71 All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 118 78 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION 86 59 All SZGR 2.0 genes in this pathway
KEGG TYPE II DIABETES MELLITUS 47 41 All SZGR 2.0 genes in this pathway
KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION 42 29 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 3.28 259 All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER 62 47 All SZGR 2.0 genes in this pathway
KEGG肾细胞CARCINOMA 70 60 All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 70 56 All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER 52 45 All SZGR 2.0 genes in this pathway
KEGG GLIOMA 65 56 All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER 89 75 All SZGR 2.0 genes in this pathway
KEGG MELANOMA 71 57 All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA 73 59 All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA 60 47 All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER 84 67 All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER 54 47 All SZGR 2.0 genes in this pathway
PID ERBB4 PATHWAY 3.8 3.2 All SZGR 2.0 genes in this pathway
PID TRAIL PATHWAY 28 20 All SZGR 2.0 genes in this pathway
PID TCPTP PATHWAY 43 3.3. All SZGR 2.0 genes in this pathway
PID FAS PATHWAY 3.8 29 All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 102 78 All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY 3.5 29 All SZGR 2.0 genes in this pathway
PID PI3KCI PATHWAY 49 40 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3 PATHWAY 44 3.5 All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129 103 All SZGR 2.0 genes in this pathway
PID NEPHRIN NEPH1 PATHWAY 3.1 24 All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY 41 3.5 All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY 43 3.4 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT 78 59 All SZGR 2.0 genes in this pathway
REACTOME IL 7 SIGNALING 11 9 All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198 112 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 3.1 23 All SZGR 2.0 genes in this pathway
REACTOME PI METABOLISM 48 3.4 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME GPVI MEDIATED ACTIVATION CASCADE 3.1 25 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184 116 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS 74 56 All SZGR 2.0 genes in this pathway
REACTOME CD28 CO STIMULATION 3.2 26 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 3.68 All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 63 48 All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING 22 18 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 107 86 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 3.02 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF SIGNALING BY CBL 18 16 All SZGR 2.0 genes in this pathway
REACTOME IL 3 5和GM CSF信号 43 3.4 All SZGR 2.0 genes in this pathway
REACTOME IL RECEPTOR SHC SIGNALING 27 21 All SZGR 2.0 genes in this pathway
REACTOME IL 2 SIGNALING 41 3.4 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 3.3.1 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 3.50 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
PYEON HPV POSITIVE TUMORS UP 98 47 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 3.84 All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE DN 92 51 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS UP 81 40 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE DN 61 3.5 All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN 240 171 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP 162 116 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN 146 94 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG DN 59 40 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 3.3.4 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY UP 109 69 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176 115 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN DN 19 14 All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN 187 122 All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS DN 87 69 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 3.3.7 230 All SZGR 2.0 genes in this pathway
YAGI AML SURVIVAL 129 87 All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS TEMPORAL DN 25 16 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 3.23 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP 180 125 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178 111 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR UP 18 13 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578 3.41 All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING DN 3.6 24 All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250 168 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216 143 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 3.42 220 All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175 125 All SZGR 2.0 genes in this pathway
GU PDEF TARGETS DN 3.9 20 All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM DN 40 3.1 All SZGR 2.0 genes in this pathway
WENDT COHESIN TARGETS UP 3.3. 19 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR UP 101 65 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567 3.65 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 3.97 206 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 3.28 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 3.15 215 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR DN 244 157 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP 221 120 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-148/152 202 209 1A,m8 hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-181 116 122 m8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-19 95 102 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-25/32/92/363/367 3.507 3.513 1A hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-26 734 740 1A hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-29 888 894 m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
miR-346 2189 2196 1A,m8 hsa-miR-346brain UGUCUGCCCGCAUGCCUGCCUCU
miR-9 495 501 m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA