Gene Page:BHLHE40

Summary？
基因 8553
象征 BHLHE40
Synonyms bhlhb2 | dec1 | hlhb2 | sharp-2 | stra13 | stra14
Description 基本的螺旋环螺旋家庭成员E40
Reference MIM:604256|HGNC:HGNC:1046|ENSEMBL：ENSG00000134107|HPRD:16050|Vega:OTTHUMG00000119035
基因类型 蛋白质编码
Map location 3P26
Pascal p-value 0.053
Sherlock p-value 0.723
胎儿β -3.271

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp 全基因组协会研究 GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
iqsec1 0.92 0.91
C2ORF21 0.90 0.86
NLK 0.90 0.84
ARHGAP26 0.89 0.87
NPTN 0.89 0.83
CNNM1 0.89 0.86
KCNMA1 0.89 0.83
RNF6 0.89 0.84
htr5a 0.89 0.82
SLC12A5 0.89 0.83
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
BCL7C -0.55 -0.63
AC006276.2 -0.48 -0.50
HEBP2 -0.46 -0.59
RPL35 -0.46 -0.52
C9orf46 -0.46 -0.47
RPL36 -0.45 -0.53
RPLP1 -0.45 -0.50
RPL31 -0.44 -0.49
RPS18 -0.44 -0.48
RPL23A -0.43 -0.47

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG CIRCADIAN RHYTHM MAMMAL 13 13 All SZGR 2.0 genes in this pathway
PID HIF2Pathway 34 29 All SZGR 2.0 genes in this pathway
PID昼夜节路 16 15 All SZGR 2.0 genes in this pathway
PID HIF1 TFPathway 66 52 All SZGR 2.0 genes in this pathway
Reactome BMAL1时钟NPAS2激活昼夜节律表达 36 27 All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK 53 40 All SZGR 2.0 genes in this pathway
弗雷索莫昔芬反应 51 36 All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS UP 52 38 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN 384 230 All SZGR 2.0 genes in this pathway
Smirnov在癌症中循环内皮细胞 158 103 All SZGR 2.0 genes in this pathway
莱茵所有糖皮质激素治疗DN 362 238 All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS UP 112 68 All SZGR 2.0 genes in this pathway
Nagashima NRG1信号向上发出 176 123 All SZGR 2.0 genes in this pathway
Nagashima EGF信号向上 58 40 All SZGR 2.0 genes in this pathway
Kim WT1靶向 214 155 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP 171 112 All SZGR 2.0 genes in this pathway
DMOG的Elvidge缺氧 130 85 All SZGR 2.0 genes in this pathway
Elvidge HIF1A和HIF2A靶向DN 104 72 All SZGR 2.0 genes in this pathway
IGF1和IGF2的Pacher靶标 35 27 All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN 485 334 All SZGR 2.0 genes in this pathway
GESERICK TERT TARGETS DN 21 16 All SZGR 2.0 genes in this pathway
甲状腺癌 443 294 All SZGR 2.0 genes in this pathway
chiaradonna肿瘤转化CDC25 DN 153 100 All SZGR 2.0 genes in this pathway
Markey RB1急性lof 215 137 All SZGR 2.0 genes in this pathway
Berenjeno由Rhoa DN转变 394 258 All SZGR 2.0 genes in this pathway
McBryan Pubertal TGFB1靶向 169 127 All SZGR 2.0 genes in this pathway
MAHADEVAN RESPONSE TO MP470 DN 19 11 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3公共DN 483 336 All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向神经上皮 176 111 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER UP 227 137 All SZGR 2.0 genes in this pathway
Mohankumar TLX1靶向 414 287 All SZGR 2.0 genes in this pathway
maina vhl目标dn 18 14 All SZGR 2.0 genes in this pathway
GROSS ELK3 TARGETS DN 32 17 All SZGR 2.0 genes in this pathway
通过ELK3 DN的缺氧总缺氧 156 106 All SZGR 2.0 genes in this pathway
通过HIF1A DN的缺氧总缺氧 110 78 All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向 1037 673 All SZGR 2.0 genes in this pathway
buytaert光动力疗法压力 811 508 All SZGR 2.0 genes in this pathway
SCIAN INVERSED TARGETS OF TP53 AND TP73 DN 31 23 All SZGR 2.0 genes in this pathway
SUH COEXPRESSED WITH ID1 AND ID2 UP 19 14 All SZGR 2.0 genes in this pathway
Colin Pilocytic星形胶质细胞瘤与胶质母细胞瘤DN 28 21 All SZGR 2.0 genes in this pathway
阿米特延迟了早期基因 18 15 All SZGR 2.0 genes in this pathway
PETRETTO HEART MASS QTL CIS UP 28 15 All SZGR 2.0 genes in this pathway
Amit EGF响应60 HELA 46 32 All SZGR 2.0 genes in this pathway
Amit EGF响应60 MCF10A 39 24 All SZGR 2.0 genes in this pathway
阿米特血清反应60 mcf10a 57 42 All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK 143 96 All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CHICK 169 111 All SZGR 2.0 genes in this pathway
brocke凋亡由IL6逆转 144 98 All SZGR 2.0 genes in this pathway
甜蜜的克拉斯靶向 84 51 All SZGR 2.0 genes in this pathway
lu IL4信号传导 94 56 All SZGR 2.0 genes in this pathway
马纳洛缺氧 207 145 All SZGR 2.0 genes in this pathway
GALINDO免疫响应E TO ENTEROTOXIN 85 67 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
LEI MYB目标 318 215 All SZGR 2.0 genes in this pathway
量缺氧 98 71 All SZGR 2.0 genes in this pathway
布鲁诺造血 66 48 All SZGR 2.0 genes in this pathway
葡萄病毒感染的Debiasi凋亡 314 201 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
外邦紫外线响应集群D4 55 37 All SZGR 2.0 genes in this pathway
哈里斯缺氧 81 64 All SZGR 2.0 genes in this pathway
伦纳德缺氧 47 35 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP 178 111 All SZGR 2.0 genes in this pathway
胰岛素抵抗时的肉食正常 34 27 All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312 203 All SZGR 2.0 genes in this pathway
敏锐的回应罗格列酮DN 106 68 All SZGR 2.0 genes in this pathway
Browne HCMV感染24小时 148 96 All SZGR 2.0 genes in this pathway
Browne HCMV感染6小时DN 160 101 All SZGR 2.0 genes in this pathway
马丁尼trabectedin抗性DN 49 34 All SZGR 2.0 genes in this pathway
monnier tradiatiation肿瘤逃脱DN 373 196 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307 185 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
iwanaga癌变由Kras Pten Up 181 112 All SZGR 2.0 genes in this pathway
阿塞维多肝癌DN 540 340 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274 165 All SZGR 2.0 genes in this pathway
肝癌DN中的阿塞维多甲基化 940 425 All SZGR 2.0 genes in this pathway
Boquest干细胞培养与新鲜 425 298 All SZGR 2.0 genes in this pathway
Labbe TGFB1靶向 102 64 All SZGR 2.0 genes in this pathway
TGFB1和WNT3A的LABBE目标 111 70 All SZGR 2.0 genes in this pathway
气浆细胞瘤了 259 185 All SZGR 2.0 genes in this pathway
冬季缺氧metagene 242 168 All SZGR 2.0 genes in this pathway
法拉利对fenretinide的反应 22 16 All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346 192 All SZGR 2.0 genes in this pathway
Yoshimura MAPK8目标DN 366 257 All SZGR 2.0 genes in this pathway
Chang Core血清反应DN 209 137 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 UP 167 99 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
Han Satb1靶向DN 442 275 All SZGR 2.0 genes in this pathway
4EBP1和4EBP2的COLINA目标 356 214 All SZGR 2.0 genes in this pathway
Boyault肝癌子类G56 DN 17 9 All SZGR 2.0 genes in this pathway
Coulouarn暂时TGFB1签名 109 68 All SZGR 2.0 genes in this pathway
Boylan多发性骨髓瘤PCA3 80 54 All SZGR 2.0 genes in this pathway
PYEON CANCAR CANCAR HEAD和NECK与颈椎 193 95 All SZGR 2.0 genes in this pathway
开罗肝母细胞瘤课程DN 210 141 All SZGR 2.0 genes in this pathway
黄成人组织茎模块 721 492 All SZGR 2.0 genes in this pathway
YAO对孕酮簇1的时间反应1 68 50 All SZGR 2.0 genes in this pathway
Karlsson TGFB1靶向 127 78 All SZGR 2.0 genes in this pathway
li诱导了自然杀手 307 182 All SZGR 2.0 genes in this pathway
由PML Rara Fusion绑定的Martens 456 287 All SZGR 2.0 genes in this pathway
Kim所有疾病Calb1 Corr Up 548 370 All SZGR 2.0 genes in this pathway
Qi缺氧 140 96 All SZGR 2.0 genes in this pathway
Wierenga Stat5A靶向 217 131 All SZGR 2.0 genes in this pathway
Wierenga Stat5a Targets Group2 60 38 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 All SZGR 2.0 genes in this pathway
Johnstone Parvb目标3 430 288 All SZGR 2.0 genes in this pathway
Bruins通过TP53组B响应UVC响应 549 316 All SZGR 2.0 genes in this pathway
pasini suz12靶向DN 315 215 All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 2 DN 32 23 All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向 682 433 All SZGR 2.0 genes in this pathway
Fardin缺氧11 32 29 All SZGR 2.0 genes in this pathway
CTBP1和SATB1的Purbey目标 87 52 All SZGR 2.0 genes in this pathway
Gobert少突胶质细胞分化DN 1080 713 All SZGR 2.0 genes in this pathway
ERBB2同工型的Pedersen转移1 46 33 All SZGR 2.0 genes in this pathway
Plasari TGFB1靶向1小时 34 26 All SZGR 2.0 genes in this pathway
Plasari TGFB1靶向10小时 199 143 All SZGR 2.0 genes in this pathway
Delacroix Rarg Bound MEF 367 231 All SZGR 2.0 genes in this pathway
Delacroix RAR目标 48 33 All SZGR 2.0 genes in this pathway
Delacroix Rar Bound ES 462 273 All SZGR 2.0 genes in this pathway
Krieg缺氧不是通过KDM3A 770 480 All SZGR 2.0 genes in this pathway
phong TNF靶向 63 43 All SZGR 2.0 genes in this pathway
phong tnf响应不是通过p38 337 236 All SZGR 2.0 genes in this pathway
BOSCO过敏原诱导TH2相关模块 151 86 All SZGR 2.0 genes in this pathway
Zwang 3类由EGF瞬时诱导 222 159 All SZGR 2.0 genes in this pathway