Gene Page:KMO

Summary?
GeneID 8564
Symbol KMO
Synonyms dJ317G22.1
Description kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Reference MIM:603538|HGNC:HGNC:6381|Ensembl:ENSG00000117009|HPRD:04642|Vega:OTTHUMG00000039635
Gene type protein-coding
Map location 1q42-q44
Fetal beta -2.185

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Guipponi_2014 Whole Exome Sequencing analysis 49 DNMs were identified by comparing the exome of 53 individuals with sporadic SCZ and of their non-affected parents
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
Expression Meta-analysis of gene expression Pvalue: 1.721
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias,schizotypal Click to show details

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
KMO G T NM_003679 p.A461S missense 0.37 0 Schizophrenia DNM:Guipponi_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KIAA1244 0.79 0.79
ARID5B 0.75 0.81
FRMPD4 0.74 0.78
SNX9 0.73 0.78
DNAJC6 0.73 0.75
ANKH 0.72 0.79
C18orf1 0.72 0.75
ANKS1B 0.72 0.75
BACE1 0.72 0.74
SECISBP2L 0.71 0.69
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C1orf61 -0.45 -0.52
RAB34 -0.43 -0.43
DCI -0.42 -0.44
RFXANK -0.42 -0.47
DBI -0.41 -0.41
SERF2 -0.41 -0.45
IMPA2 -0.40 -0.44
GNG11 -0.40 -0.40
PECI -0.40 -0.45
C7orf55 -0.40 -0.42

Section III. Gene Ontology annotation

Molecular function 去后m Evidence Neuro keywords PubMed ID
GO:0004497 monooxygenase activity IEA -
GO:0004502 kynurenine 3-monooxygenase activity EXP 10672018
GO:0004502 kynurenine 3-monooxygenase activity TAS 9237672
GO:0009055 electron carrier activity TAS 9237672
Biological process 去后m Evidence Neuro keywords PubMed ID
GO:0019674 NAD metabolic process EXP 14704851
GO:0055114 oxidation reduction IEA -
Cellular component 去后m Evidence Neuro keywords PubMed ID
GO:0005829 cytosol EXP 10672018
GO:0005739 mitochondrion IEA -
GO:0005741 线粒体l outer membrane IEA -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG TRYPTOPHAN METABOLISM 40 33 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200 136 All SZGR 2.0 genes in this pathway
REACTOME TRYPTOPHAN CATABOLISM 11 9 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER CLASSES UP 72 38 All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN 241 146 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR UP 85 54 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330 217 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357 212 All SZGR 2.0 genes in this pathway
LU IL4 SIGNALING 94 56 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 All SZGR 2.0 genes in this pathway
里奇尤因肉瘤祖 430 288 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP 147 83 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 UP 111 69 All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM DN 40 31 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288 168 All SZGR 2.0 genes in this pathway
CHEN LIVER METABOLISM QTL CIS 93 40 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS INTERFERON UP 26 10 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266 180 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267 160 All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 149 85 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259 159 All SZGR 2.0 genes in this pathway
PURBEY CTBP1没有SATB1的目标 344 215 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 6 29 20 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-203.1 2449 2455 1A hsa-miR-203 UGAAAUGUUUAGGACCACUAG