Gene Page:MADD

Summary?
GeneID 8567
Symbol MADD
Synonyms DENN|IG20|RAB3GEP
Description MAP kinase activating death domain
Reference MIM:603584|HGNC:HGNC:6766|Ensembl:ENSG00000110514|HPRD:04664|Vega:OTTHUMG00000150350
Gene type protein-coding
Map location 11p11.2
Pascal p-value 0.029
Sherlock p-value 0.622
Fetal beta -0.801
eGene Cerebellar Hemisphere
Cerebellum
元
Support CompositeSet
Darnell FMRP targets
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MRPL23 0.85 0.78
C11orf83 0.85 0.81
C19orf60 0.85 0.75
POLR2L 0.84 0.74
POLR2I 0.84 0.74
MRPS11 0.84 0.73
LAGE3 0.83 0.74
LSM10 0.83 0.76
NME3 0.82 0.73
DGCR6L 0.82 0.76
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.26 -0.37 -0.36
AF347015.15 -0.36 -0.38
AF347015.2 -0.34 -0.32
MT-ATP8 -0.34 -0.38
AF347015.8 -0.34 -0.35
AF347015.18 -0.33 -0.30
MT-CYB -0.33 -0.36
AF347015.33 -0.32 -0.35
AF347015.27 -0.32 -0.37
SDPR -0.31 -0.29

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA TNFR1 PATHWAY 29 21 All SZGR 2.0 genes in this pathway
PID TNF PATHWAY 46 33 All SZGR 2.0 genes in this pathway
PID CERAMIDE PATHWAY 48 37 All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY 52 39 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180 101 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229 142 All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER UP 100 75 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
LEIN NEURON MARKERS 69 45 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 120 81 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225 124 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
金所有障碍少突细胞NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN 146 90 All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL DN 214 124 All SZGR 2.0 genes in this pathway