Gene Page:KHSRP
概括?
| 基因 | 8570 |
| 象征 | KHSRP |
| Synonyms | FBP2|FUBP2|KSRP |
| Description | KH-type splicing regulatory protein |
| Reference | MIM:603445|HGNC:HGNC:6316|Ensembl:ENSG00000088247|HPRD:10350|Vega：Otthumg00000180850 |
| Gene type | protein-coding |
| Map location | 19p13.3 |
| Pascal p-value | 0.395 |
| Sherlock p-value | 0.145 |
| Fetal beta | 0.845 |
| DMG | 1（＃研究） |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
第一节遗传学和表观遗传学注释
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg08340521 | 19 | 6424783 | KHSRP | 9.18e-6 | -0.274 | 0.013 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| COL14A1 | 0.82 | 0.86 |
| acta2 | 0.80 | 0.85 |
| FAM129A | 0.80 | 0.77 |
| JPH2 | 0.75 | 0.79 |
| MYH11 | 0.75 | 0.80 |
| MRGPRF | 0.71 | 0.78 |
| COL8A1 | 0.71 | 0.80 |
| C7orf58 | 0.70 | 0.60 |
| TBX18 | 0.68 | 0.74 |
| FHL5 | 0.66 | 0.73 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RP9 | -0.45 | -0.56 |
| ZNF433 | -0.44 | -0.53 |
| CYP2R1 | -0.43 | -0.56 |
| CCDC23 | -0.43 | -0.54 |
| RPAIN | -0.43 | -0.52 |
| trnau1ap | -0.42 | -0.52 |
| TUBB2B | -0.42 | -0.42 |
| RPS13P2 | -0.42 | -0.60 |
| Dynlt1 | -0.42 | -0.60 |
| RPL23A | -0.42 | -0.57 |
第四节。蛋白质蛋白相互作用注释
| 互动者 | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| A1CF | ACF |ACF64 |ACF65 |apobec1cf |ASP |MGC163391 |RP11-564C4.2 | APOBEC1 complementation factor | - | HPRD,BioGRID | 10781591 |
| BACE1 | ASP2 | BACE | FLJ90568 | HSPC104 | KIAA1149 | beta-site APP-cleaving enzyme 1 | BACE1与KHSRP相互作用。这种相互作用是在小鼠BACE1和人KHSRP之间证明的相互作用上建模的。 | BIND | 15606899 |
| EXOSC2 | RRP4 | Rrp4p | hRrp4p | p7 | 外泌体组件2 | KSRP与HRRP4P相互作用。 | BIND | 15175153 |
| EXOSC2 | RRP4 | Rrp4p | hRrp4p | p7 | 外泌体组件2 | - | HPRD,BioGRID | 15175153 |
| EXOSC3 | CGI-102 | MGC15120 | MGC723 | RP11-3J10.8 | RRP40 | Rrp40p | bA3J10.7 | hRrp40p | p10 | 外泌体组件3 | - | HPRD | 11719186|15175153 | 15175153 |
| EXOSC3 | CGI-102 | MGC15120 | MGC723 | RP11-3J10.8 | RRP40 | Rrp40p | bA3J10.7 | hRrp40p | p10 | 外泌体组件3 | KSRP与HRRP40P相互作用。 | BIND | 15175153 |
| FOS | AP-1 |c-fos | v-fos FBJ murine osteosarcoma viral oncogene homolog | KSRP与Arefos相互作用。这种相互作用是根据来自人类的KSRP与未指定物种的AREFO之间的相互作用进行建模的。 | BIND | 15175153 |
| FUBP1 | FBP | FUBP | 上游元素（保险丝）结合蛋白1 | - | HPRD | 11003644 |
| HNRNPA1 | HNRPA1 | MGC102835 | 异质核核糖核蛋白A1 | Reconstituted Complex | BioGRID | 11003644 |
| HNRNPF | HNRPF | MGC110997 | OK/SW-cl.23 | mcs94-1 | heterogeneous nuclear ribonucleoprotein F | - | HPRD | 9858532 |
| HNRNPH1 | DKFZp686A15170 | HNRPH | HNRPH1 | hnRNPH | 异构核核糖核蛋白H1 (H) | - | HPRD,BioGRID | 9858532|11003644 |
| IL2 | IL-2 | TCGF | lymphokine | 白介素2 | KSRP与IL-2 3'UTR相互作用。这种相互作用是根据来自人类和未指定物种的IL-2 3'UTR的KSRP的相互作用进行建模的。 | BIND | 15175153 |
| JUN | AP-1 |AP1 | c-Jun | Jun Oncogene | KSRP interacts with AREjun. This interaction was modeled on a demonstrated interaction between KSRP from human and AREjun from an unspecified species. | BIND | 15175153 |
| 帕恩 | DAN | poly(A)-specific ribonuclease (deadenylation nuclease) | - | HPRD,BioGRID | 15175153 |
| PTBP1 | HNRNP-I | HNRNPI | HNRPI | MGC10830 | MGC8461 | PTB | PTB-1 | PTB-T | PTB2 | PTB3 | PTB4 | pPTB | polypyrimidine tract binding protein 1 | - | HPRD | 11003644 |
| PTBP2 | FLJ34897 | PTB | PTBLP | brPTB | nPTB | nPTB5 | nPTB6 | nPTB7 | nPTB8 | polypyrimidine tract binding protein 2 | Reconstituted Complex | BioGRID | 11003644 |
| PUF60 | FIR | FLJ31379 | RoBPI | SIAHBP1 | poly-U binding splicing factor 60KDa | 亲和力捕获ms | BioGRID | 17353931 |
| TNF | DIF | TNF-alpha | TNFA | TNFSF2 | 肿瘤坏死因子（TNF超家族，成员2） | KSRP interacts with AREtnf. This interaction was modeled on a demonstrated interaction between KSRP from human and AREtnf from an unspecified species. | BIND | 15175153 |
V.途径注释
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| Reactome糖尿病途径 | 133 | 91 | 该途径中的所有SZGR 2.0基因 |
| REACTOME PERK REGULATED GENE EXPRESSION | 29 | 14 | 该途径中的所有SZGR 2.0基因 |
| ATF4对基因激活的反应组激活 | 26 | 12 | 该途径中的所有SZGR 2.0基因 |
| Reactome展开的蛋白质反应 | 80 | 51 | 该途径中的所有SZGR 2.0基因 |
| REACTOME METABOLISM OF MRNA | 284 | 128 | 该途径中的所有SZGR 2.0基因 |
| REACTOME METABOLISM OF RNA | 330 | 155 | 该途径中的所有SZGR 2.0基因 |
| REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | 84 | 50 | 该途径中的所有SZGR 2.0基因 |
| REACTOME DESTABILIZATION OF MRNA BY KSRP | 17 | 9 | 该途径中的所有SZGR 2.0基因 |
| 渡边直肠癌放射疗法反应性DN | 92 | 51 | 该途径中的所有SZGR 2.0基因 |
| Fulcher炎症反应凝集素与LPS | 579 | 346 | 该途径中的所有SZGR 2.0基因 |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | 该途径中的所有SZGR 2.0基因 |
| LAIHO COLORECTAL CANCER SERRATED DN | 86 | 47 | 该途径中的所有SZGR 2.0基因 |
| GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN | 335 | 193 | 该途径中的所有SZGR 2.0基因 |
| TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP | 204 | 140 | 该途径中的所有SZGR 2.0基因 |
| UDAYAKUMAR MED1 TARGETS DN | 240 | 171 | 该途径中的所有SZGR 2.0基因 |
| KIM WT1 TARGETS 8HR UP | 164 | 122 | 该途径中的所有SZGR 2.0基因 |
| 多德鼻咽癌DN | 1375 | 806 | 该途径中的所有SZGR 2.0基因 |
| ENK UV RESPONSE KERATINOCYTE DN | 485 | 334 | 该途径中的所有SZGR 2.0基因 |
| OUELLET OVARIAN CANCER INVASIVE VS LMP DN | 11 | 8 | 该途径中的所有SZGR 2.0基因 |
| SCHLOSSER MYC AND SERUM RESPONSE SYNERGY | 32 | 22 | 该途径中的所有SZGR 2.0基因 |
| DAIRKEE TERT TARGETS UP | 380 | 213 | 该途径中的所有SZGR 2.0基因 |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | 该途径中的所有SZGR 2.0基因 |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | 该途径中的所有SZGR 2.0基因 |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | 该途径中的所有SZGR 2.0基因 |
| CAFFAREL RESPONSE TO THC 24HR 5 UP | 34 | 23 | 该途径中的所有SZGR 2.0基因 |
| Benporath Nanog目标 | 988 | 594 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH MYC MAX TARGETS | 775 | 494 | 该途径中的所有SZGR 2.0基因 |
| PETRETTO BLOOD PRESSURE UP | 12 | 8 | 该途径中的所有SZGR 2.0基因 |
| SHEN SMARCA2 TARGETS DN | 357 | 212 | 该途径中的所有SZGR 2.0基因 |
| PENG LEUCINE DEPRIVATION UP | 142 | 93 | 该途径中的所有SZGR 2.0基因 |
| 彭谷氨酰胺剥夺DN | 337 | 230 | 该途径中的所有SZGR 2.0基因 |
| FERRANDO T ALL WITH MLL ENL FUSION DN | 87 | 57 | 该途径中的所有SZGR 2.0基因 |
| Taci的Moreaux多发性骨髓瘤 | 412 | 249 | 该途径中的所有SZGR 2.0基因 |
| MOREAUX B LYMPHOCYTE MATURATION BY TACI UP | 92 | 58 | 该途径中的所有SZGR 2.0基因 |
| KAAB HEART ATRIUM VS VENTRICLE UP | 249 | 170 | 该途径中的所有SZGR 2.0基因 |
| Kayo衰老的肌肉 | 244 | 165 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE UP | 1691年 | 1088 | 该途径中的所有SZGR 2.0基因 |
| BACOLOD RESISTANCE TO ALKYLATING AGENTS DN | 60 | 45 | 该途径中的所有SZGR 2.0基因 |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | 该途径中的所有SZGR 2.0基因 |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | 该途径中的所有SZGR 2.0基因 |
| DAIRKEE CANCER PRONE RESPONSE BPA E2 | 118 | 65 | 该途径中的所有SZGR 2.0基因 |
| ACEVEDO LIVER CANCER DN | 540 | 340 | 该途径中的所有SZGR 2.0基因 |
| GRADE COLON CANCER UP | 871 | 505 | 该途径中的所有SZGR 2.0基因 |
| DANG BOUND BY MYC | 1103 | 714 | 该途径中的所有SZGR 2.0基因 |
| DASU IL6 SIGNALING UP | 59 | 44 | 该途径中的所有SZGR 2.0基因 |
| 双龙血清敏感基因 | 90 | 54 | 该途径中的所有SZGR 2.0基因 |
| BILANGES SERUM RESPONSE TRANSLATION | 37 | 20 | 该途径中的所有SZGR 2.0基因 |
| PURBEY TARGETS OF CTBP1 AND SATB1 DN | 180 | 116 | 该途径中的所有SZGR 2.0基因 |