Gene Page:RUNX2

Summary?
GeneID 860
Symbol RUNX2
Synonyms AML3|CBF-alpha-1|CBFA1|CCD|CCD1|CLCD|OSF-2|OSF2|PEA2aA|PEBP2aA
Description runt related transcription factor 2
Reference MIM:600211|HGNC:HGNC:10472|Ensembl:ENSG00000124813|HPRD:02566|Vega:OTTHUMG00000014774
Gene type protein-coding
Map location 6p21
Pascal p-value 0.724
Fetal beta 0.237
DMG 1 (# studies)
eGene Caudate basal ganglia

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.04433
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg23376821 6 45391365 RUNX2 7.01E-8 -0.011 1.7E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TBX2 0.68 0.63
ITPKB 0.67 0.57
CHDH 0.66 0.54
TPCN1 0.65 0.56
GPR37L1 0.65 0.56
FAM38A 0.64 0.58
NACC2 0.64 0.56
GPER 0.64 0.60
PBXIP1 0.64 0.56
NFATC1 0.64 0.58
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MED19 -0.49 -0.52
C18orf21 -0.47 -0.49
POLB -0.46 -0.52
FRG1 -0.46 -0.52
COQ3 -0.46 -0.48
ING4 -0.46 -0.49
PAK1IP1 -0.45 -0.46
FARSB -0.45 -0.47
ASNSD1 -0.45 -0.46
DUSP12 -0.45 -0.47

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003682 chromatin binding IEA -
GO:0003700 transcription factor activity IEA -
GO:0003700 transcription factor activity NAS 9182765
GO:0003702 RNA polymerase II transcription factor activity TAS 9182762
GO:0005515 protein binding 新闻学会 11965546|12145306
GO:0005524 ATP binding IEA -
GO:0016563 transcription activator activity IDA 11965546
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0001501 skeletal system development IEA -
GO:0001649 osteoblast differentiation IEA -
GO:0001649 osteoblast differentiation TAS 12217689
GO:0002062 chondrocyte differentiation IEA -
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0008284 positive regulation of cell proliferation IEA -
GO:0048469 cell maturation IEA -
GO:0016481 negative regulation of transcription IDA 11965546
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway IEA -
GO:0042487 regulation of odontogenesis of dentine-containing tooth IEA -
GO:0045879 negative regulation of smoothened signaling pathway IEA -
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -
GO:0005737 cytoplasm IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CBFB PEBP2B core-binding factor, beta subunit - HPRD 12434156
CEBPB C/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5 CCAAT/enhancer binding protein (C/EBP), beta - HPRD 11668178
ETS1 ETS-1 | EWSR2 | FLJ10768 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) - HPRD,BioGRID 9794229
FOS AP-1 | C-FOS v-fos FBJ murine osteosarcoma viral oncogene homolog - HPRD,BioGRID 11641401
HDAC3 HD3 | RPD3 | RPD3-2 histone deacetylase 3 Affinity Capture-Western
Reconstituted Complex		 BioGRID 15292260
HDAC6 FLJ16239 | HD6 | JM21 histone deacetylase 6 - HPRD,BioGRID 12391164
JUN AP-1 | AP1 | c-Jun jun oncogene - HPRD,BioGRID 11274169|11641401
LEF1 DKFZp586H0919 | TCF1ALPHA lymphoid enhancer-binding factor 1 Reconstituted Complex BioGRID 12551949
MSX2 CRS2 | FPP | HOX8 | MSH | PFM | PFM1 msh homeobox 2 - HPRD,BioGRID 11683913
MYST4 DKFZp313G1618 | FLJ90335 | KAT6B | KIAA0383 | MORF | MOZ2 | qkf | querkopf MYST histone acetyltransferase (monocytic leukemia) 4 - HPRD,BioGRID 11965546
RB1 OSRC | RB | p105-Rb | pRb | pp110 retinoblastoma 1 Runx2 interacts with pRb. BIND 15583032
SMAD1 BSP1 | JV4-1 | JV41 | MADH1 | MADR1 SMAD family member 1 Affinity Capture-Western BioGRID 10531362|10962029
SMAD2 JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2 SMAD family member 2 - HPRD,BioGRID 10531362
SMAD3 DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396 SMAD family member 3 - HPRD,BioGRID 10962029
SMAD5 DKFZp781C1895 | DKFZp781O1323 | Dwfc | JV5-1 | MADH5 SMAD family member 5 Affinity Capture-Western BioGRID 10531362
THOC4 ALY | BEF THO complex 4 Reconstituted Complex BioGRID 9119228
YAP1 YAP | YAP2 | YAP65 | YKI Yes-associated protein 1, 65kDa - HPRD,BioGRID 10228168


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID SMAD2 3NUCLEAR PATHWAY 82 63 All SZGR 2.0 genes in this pathway
PID FGF PATHWAY 55 37 All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY 65 46 All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY 48 39 All SZGR 2.0 genes in this pathway
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 24 16 All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY 352 181 All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS UP 94 57 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
RODRIGUES DCC TARGETS DN 121 84 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN 260 143 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316 190 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
MARTIN INTERACT WITH HDAC 44 31 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392 251 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164 111 All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2 153 102 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357 212 All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS 183 115 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
ABRAHAM ALPC VS MULTIPLE MYELOMA UP 26 22 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
SU PANCREAS 54 30 All SZGR 2.0 genes in this pathway
击倒卡路里限制肌肉DN 87 59 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
BILD CTNNB1 ONCOGENIC SIGNATURE 82 52 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR DN 191 123 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A UP 111 70 All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL DN 43 28 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252 155 All SZGR 2.0 genes in this pathway
ZAIDI OSTEOBLAST TRANSCRIPTION FACTORS 14 12 All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346 192 All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE DN 75 61 All SZGR 2.0 genes in this pathway
Han Satb1靶向 395 249 All SZGR 2.0 genes in this pathway
ONO AML1 TARGETS DN 41 25 All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS DN 42 23 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254 158 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216 130 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336 211 All SZGR 2.0 genes in this pathway
DUAN PRDM5 TARGETS 79 52 All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 1 46 33 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 1529 1535 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 1529 1535 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-130/301 2728 2734 m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-135 1015 1021 1A hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-137 1036 1042 m8 hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-148/152 2729 2735 m8 hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-153 741 747 1A hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-19 2727 2733 m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-203.1 934 940 m8 hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-204/211 3653 3659 m8 hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-205 1124 1131 1A,m8 hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-218 1308 1315 1A,m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-221/222 3512 3518 1A hsa-miR-221brain AGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brain AGCUACAUCUGGCUACUGGGUCUC
miR-224 623 629 m8 hsa-miR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-23 1061 1067 m8 hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-30-5p 3348 3354 m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-323 1061 1067 1A hsa-miR-323brain GCACAUUACACGGUCGACCUCU
miR-324-5p 2492 2498 m8 hsa-miR-324-5p CGCAUCCCCUAGGGCAUUGGUGU
miR-330 391 398 1A,m8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-338 1242 1249 1A,m8 hsa-miR-338brain UCCAGCAUCAGUGAUUUUGUUGA
miR-369-3p 768 774 1A hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 768 774 m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-383 639 645 1A hsa-miR-383brain AGAUCAGAAGGUGAUUGUGGCU
miR-448 741 747 1A hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-485-3p 1121 1128 1A,m8 hsa-miR-485-3p GUCAUACACGGCUCUCCUCUCU
miR-495 3771 3777 1A hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-543 2510 2516 1A hsa-miR-543 AAACAUUCGCGGUGCACUUCU
miR-9 2764 2770 m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA