Gene Page:CBFA2T3
概括?
| 基因 | 863 |
| Symbol | CBFA2T3 |
| Synonyms | ETO2|MTG16|MTGR2|ZMYND4 |
| Description | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 |
| Reference | MIM:603870|HGNC:HGNC:1537|Ensembl:ENSG00000129993|HPRD:04847|Vega:OTTHUMG00000137864 |
| Gene type | protein-coding |
| Map location | 16q24 |
| Pascal p-value | 0.033 |
| Sherlock p-value | 0.257 |
| Fetal beta | 0.973 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
第一节遗传学和表观遗传学注释
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg05751310 | 16 | 88963738 | CBFA2T3 | 5.104E-4 | -0.288 | 0.047 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6543365 | 0 | CBFA2T3 | 863 | 0.19 | trans | |||
| rs16829545 | chr2 | 151977407 | CBFA2T3 | 863 | 7.901E-8 | trans | ||
| rs7584986 | chr2 | 184111432 | CBFA2T3 | 863 | 4.68E-5 | trans | ||
| rs6741060 | chr2 | 217169088 | CBFA2T3 | 863 | 0.09 | trans | ||
| rs17762315 | chr5 | 76807576 | CBFA2T3 | 863 | 0.07 | trans | ||
| rs4836433 | chr5 | 128361954 | CBFA2T3 | 863 | 0.06 | trans | ||
| rs16955618 | chr15 | 29937543 | CBFA2T3 | 863 | 6.19E-13 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| EIF2C2 | 0.95 | 0.94 |
| CRKRS | 0.92 | 0.93 |
| AFF4 | 0.92 | 0.96 |
| PCNX | 0.91 | 0.95 |
| DCP1A | 0.91 | 0.91 |
| KIF1B | 0.91 | 0.95 |
| SLC12A6 | 0.91 | 0.93 |
| SEC16A | 0.90 | 0.90 |
| HELZ | 0.90 | 0.94 |
| KIAA1632 | 0.90 | 0.93 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FXYD1 | -0.61 | -0.76 |
| AF347015.31 | -0.60 | -0.75 |
| HIGD1B | -0.60 | -0.76 |
| MT-CO2 | -0.60 | -0.75 |
| IFI27 | -0.59 | -0.74 |
| AF347015.33 | -0.57 | -0.69 |
| CXCL14 | -0.57 | -0.73 |
| S100B | -0.56 | -0.68 |
| MT-CYB | -0.56 | -0.70 |
| C5orf53 | -0.56 | -0.62 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| CBFA2T2 | DKFZp313F2116 | EHT | MTGR1 | ZMYND3 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | - | HPRD,BioGRID | 12242670 |
| CBFA2T3 | ETO2 | MTG16 | MTGR2 | ZMYND4 | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 | - | HPRD | 14703694 |
| HDAC1 | DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1 | histone deacetylase 1 | - | HPRD,BioGRID | 12242670 |
| HDAC2 | RPD3 | YAF1 | histone deacetylase 2 | Affinity Capture-Western | BioGRID | 11533236 |
| HDAC3 | HD3 | RPD3 | RPD3-2 | histone deacetylase 3 | - | HPRD,BioGRID | 12242670 |
| HDAC6 | FLJ16239 | HD6 | JM21 | histone deacetylase 6 | Affinity Capture-Western | BioGRID | 11533236 |
| HDAC8 | HDACL1 | RPD3 | histone deacetylase 8 | Affinity Capture-Western | BioGRID | 11533236 |
| LDB1 | CLIM2 | NLI | 林域结合1 | Affinity Capture-Western | BioGRID | 16407974 |
| NCOR1 | KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoR | nuclear receptor co-repressor 1 | Affinity Capture-Western | BioGRID | 11533236 |
| PRKAR2A | MGC3606 | PKR2 | PRKAR2 | protein kinase, cAMP-dependent, regulatory, type II, alpha | - | HPRD,BioGRID | 11823486 |
| RUNX1 | AML1 | AML1-EVI-1 | AMLCR1 | CBFA2 | EVI-1 | PEBP2aB | runt-related transcription factor 1 | - | HPRD | 14703694 |
| RUNX1T1 | AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | - | HPRD,BioGRID | 14703694 |
| TAL1 | SCL | TCL5 | bHLHa17 | tal-1 | T-cell acute lymphocytic leukemia 1 | Affinity Capture-MS Affinity Capture-Western Reconstituted Complex |
BioGRID | 16407974 |
| TCF3 | E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21 | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) | Affinity Capture-Western Reconstituted Complex |
BioGRID | 16407974 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID ERBB4 PATHWAY | 38 | 32 | 该途径中的所有SZGR 2.0基因 |
| WANG LMO4 TARGETS UP | 372 | 227 | 该途径中的所有SZGR 2.0基因 |
| TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN | 187 | 115 | 该途径中的所有SZGR 2.0基因 |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | 该途径中的所有SZGR 2.0基因 |
| PEREZ TP53 TARGETS | 1174 | 695 | 该途径中的所有SZGR 2.0基因 |
| AUNG GASTRIC CANCER | 54 | 20 | 该途径中的所有SZGR 2.0基因 |
| SCHLOSSER SERUM RESPONSE UP | 134 | 93 | 该途径中的所有SZGR 2.0基因 |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | 该途径中的所有SZGR 2.0基因 |
| PUJANA ATM PCC NETWORK | 1442 | 892 | 该途径中的所有SZGR 2.0基因 |
| NIKOLSKY BREAST CANCER 16Q24 AMPLICON | 53 | 38 | 该途径中的所有SZGR 2.0基因 |
| TENEDINI MEGAKARYOCYTE MARKERS | 66 | 48 | 该途径中的所有SZGR 2.0基因 |
| LEE LIVER CANCER CIPROFIBRATE UP | 60 | 42 | 该途径中的所有SZGR 2.0基因 |
| FAELT B CLL WITH VH REARRANGEMENTS UP | 48 | 34 | 该途径中的所有SZGR 2.0基因 |
| 棕色髓样细胞发育DN | 129 | 86 | 该途径中的所有SZGR 2.0基因 |
| THEILGAARD NEUTROPHIL AT SKIN WOUND DN | 225 | 163 | 该途径中的所有SZGR 2.0基因 |
| CUI TCF21 TARGETS 2 DN | 830 | 547 | 该途径中的所有SZGR 2.0基因 |
| BROWNE HCMV INFECTION 18HR DN | 178 | 121 | 该途径中的所有SZGR 2.0基因 |
| IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR | 681 | 420 | 该途径中的所有SZGR 2.0基因 |
| IWANAGA CARCINOGENESIS BY KRAS PTEN DN | 353 | 226 | 该途径中的所有SZGR 2.0基因 |
| OSADA ASCL1 TARGETS UP | 46 | 30 | 该途径中的所有SZGR 2.0基因 |
| SMID BREAST CANCER BASAL DN | 701 | 446 | 该途径中的所有SZGR 2.0基因 |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | 该途径中的所有SZGR 2.0基因 |
| GRESHOCK CANCER COPY NUMBER UP | 323 | 240 | 该途径中的所有SZGR 2.0基因 |
| WU ALZHEIMER DISEASE UP | 14 | 8 | 该途径中的所有SZGR 2.0基因 |
| WONG ADULT TISSUE STEM MODULE | 721 | 492 | 该途径中的所有SZGR 2.0基因 |
| MIKKELSEN ES LCP WITH H3K4ME3 | 142 | 80 | 该途径中的所有SZGR 2.0基因 |
| BROWNE HCMV INFECTION 30MIN DN | 150 | 99 | 该途径中的所有SZGR 2.0基因 |
| ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN | 116 | 74 | 该途径中的所有SZGR 2.0基因 |
| PILON KLF1 TARGETS DN | 1972 | 1213 | 该途径中的所有SZGR 2.0基因 |
| BHAT ESR1 TARGETS NOT VIA AKT1 UP | 211 | 131 | 该途径中的所有SZGR 2.0基因 |
| BHAT ESR1 TARGETS VIA AKT1 UP | 281 | 183 | 该途径中的所有SZGR 2.0基因 |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | 该途径中的所有SZGR 2.0基因 |
| HOLLEMAN VINCRISTINE RESISTANCE ALL UP | 27 | 16 | 该途径中的所有SZGR 2.0基因 |