Gene Page:SKAP1

Summary?
GeneID 8631
Symbol SKAP1
Synonyms HEL-S-81p|SCAP1|SKAP55
Description src kinase associated phosphoprotein 1
Reference MIM:604969|HGNC:HGNC:15605|Ensembl:ENSG00000141293|HPRD:05396|Vega:OTTHUMG00000178823
Gene type protein-coding
Map location 17q21.32
Pascal p-value 0.006
Fetal beta 0.527
DMG 1 (# studies)
eGene Caudate basal ganglia

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg19585103 17 46507549 SKAP1 2.95E-4 -0.446 0.039 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ZNF474 0.83 0.34
DNAI1 0.82 0.40
MNS1 0.82 0.28
TEX9 0.80 0.35
NUP62CL 0.80 0.44
C12orf55 0.80 0.38
TMEM67 0.79 0.30
DZIP1L 0.79 0.39
C12orf63 0.78 0.38
CCDC40 0.78 0.30
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MGLL -0.31 -0.34
EPB49 -0.31 -0.37
CHN1 -0.30 -0.32
BCL2L2 -0.30 -0.32
SNCB -0.30 -0.40
TUBA1 -0.30 -0.34
CBX7 -0.29 -0.32
CAP2 -0.29 -0.47
RUNDC3A -0.29 -0.37
ADAP1 -0.29 -0.34

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
HOLLMANN APOPTOSIS VIA CD40 DN 267 178 All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206 111 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406 230 All SZGR 2.0 genes in this pathway
LI CISPLATIN RESISTANCE DN 35 20 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION UP 74 51 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY UV 62 43 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226 164 All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469 239 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN 274 165 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317 177 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267 160 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway