Gene Page:EIF3J

Summary?
GeneID 8669
Symbol EIF3J
Synonyms EIF3S1|eIF3-alpha|eIF3-p35
Description eukaryotic translation initiation factor 3 subunit J
Reference MIM:603910|HGNC:HGNC:3270|Ensembl:ENSG00000104131|HPRD:04883|Vega:OTTHUMG00000131158
Gene type protein-coding
Map location 15q21.1
Pascal p-value 0.06
Sherlock p-value 0.396
Fetal beta -0.259
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg08749862 15 44829310 EIF3J 6.04E-10 -0.011 9.07E-7 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
EIF3A EIF3 | EIF3S10 | KIAA0139 | P167 | TIF32 | eIF3-p170 | eIF3-theta | p180 | p185 eukaryotic translation initiation factor 3, subunit A - HPRD,BioGRID 9822659
EIF3B EIF3-ETA | EIF3-P110 | EIF3-P116 | EIF3S9 | MGC104664 | MGC131875 | PRT1 eukaryotic translation initiation factor 3, subunit B Co-purification BioGRID 15946946
EIF3C EIF3S8 | FLJ78287 | MGC189744 | eIF3-p110 eukaryotic translation initiation factor 3, subunit C - HPRD,BioGRID 9822659
EIF3D EIF3S7 | MGC126526 | MGC17258 | eIF3-p66 | eIF3-zeta eukaryotic translation initiation factor 3, subunit D - HPRD,BioGRID 9822659
EIF3K ARG134 | EIF3-p28 | EIF3S12 | HSPC029 | M9 | MSTP001 | PLAC-24 | PLAC24 | PRO1474 | PTD001 eukaryotic translation initiation factor 3, subunit K - HPRD,BioGRID 14519125
EIF6 2 | CAB | EIF3A | ITGB4BP | b | b(2)gcn | gcn | p27BBP eukaryotic translation initiation factor 6 Co-purification BioGRID 15946946
GOLM1 C9orf155 | FLJ22634 | FLJ23608 | GOLPH2 | GP73 | PSEC0257 | bA379P1.3 golgi membrane protein 1 Two-hybrid BioGRID 16169070
MAGED1 DLXIN-1 | NRAGE melanoma antigen family D, 1 Two-hybrid BioGRID 16169070
SIAH1 FLJ08065 | HUMSIAH | Siah-1 | Siah-1a | hSIAH1 seven in absentia homolog 1 (Drosophila) - HPRD,BioGRID 9822659
TADA3L ADA3 | FLJ20221 | FLJ21329 | hADA3 transcriptional adaptor 3 (NGG1 homolog, yeast)-like Two-hybrid BioGRID 16169070
TPD52L1 D53 | MGC8556 | TPD52L2 | hD53 tumor protein D52-like 1 Two-hybrid BioGRID 16169070


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME TRANSLATION 222 75 All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX 74 24 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 84 30 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518 242 All SZGR 2.0 genes in this pathway
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION 176 51 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
BERENJENO通过RHOA转换 536 340 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS UP 201 127 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514 330 All SZGR 2.0 genes in this pathway
GOLDRATH HOMEOSTATIC PROLIFERATION 171 102 All SZGR 2.0 genes in this pathway
WILLERT WNT SIGNALING 24 13 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206 118 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER DN 41 34 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
CHNG MULTIPLE MYELOMA HYPERPLOID UP 52 25 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306 191 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 7 76 46 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS UP 84 51 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 DN 180 116 All SZGR 2.0 genes in this pathway