Gene Page:CBL

Summary？
基因 867
Symbol CBL
Synonyms C-CBL|CBL2|FRA11B|NSLL|RNF55
Description Cbl原癌基因,E3泛素蛋白连接酶
Reference MIM：165360|HGNC:HGNC:1541|Ensembl:ENSG00000110395|HPRD:01320|Vega:OTTHUMG00000166170
Gene type 蛋白质编码
Map location 11q23.3
Pascal p-value 0.141
胎儿β 0.019
主持人 Cerebellum

Gene in Data Sources
Gene set name Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
PMID：cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.006
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias 点击显示详细信息
Network Shortest path distance of core genes in the Human protein-protein interaction network PPI网络中最短路径的贡献：0.0043

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
Gene Pearson's Correlation Spearman's Correlation
STRA6 0.64 0.66
MMP2 0.63 0.71
EPHB4 0.63 0.71
SLC3A2 0.63 0.64
PDIA4 0.62 0.62
HTRA3 0.61 0.68
VASP 0.60 0.72
FSTL1 0.60 0.67
NID1 0.60 0.74
CMTM3 0.60 0.66
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ASPA -0.42 -0.52
RBP7 -0.41 -0.56
蛋白石 -0.41 -0.56
EVI2A -0.40 -0.52
马尔 -0.40 -0.49
RNase1 -0.40 -0.47
CAPN3 -0.39 -0.57
SEPT4 -0.39 -0.50
dbndd2 -0.39 -0.45
PLLP -0.39 -0.46

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0004871 signal transducer activity IEA -
GO:0003700 transcription factor activity TAS 2030914
去：0005509 calcium ion binding IEA -
去：0005515 蛋白质结合 IPI 11891219
去：0005525 GTP binding IEA -
GO:0004842 ubiquitin-protein ligase activity EXP 12218189|12593796|16407834
GO:0004842 ubiquitin-protein ligase activity TAS 15465819
GO：0016874 ligase activity IEA -
GO:0008270 zinc ion binding IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0007173 epidermal growth factor receptor signaling pathway TAS 15465819
GO:0006511 ubiquitin-dependent protein catabolic process IEA -
GO:0007166 细胞表面受体信号转导有关 TAS 15465819
去：0007017 microtubule-based process IEA -
GO:0016567 蛋白质泛素化 TAS 15465819
GO：0048260 positive regulation of receptor-mediated endocytosis TAS 15465819
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0005829 cytosol EXP 8621719|11823423|14505571
GO:0005874 microtubule IEA -
GO:0005634 nucleus IEA -
去：0005737 cytoplasm IEA -
GO:0005886 plasma membrane EXP 10567358|11894095|12218189
|12593796|15475003
|15962011|16407834
GO:0005886 plasma membrane IDA 15465819

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B 实验 Source PubMed ID
ABL1 ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl c-abl oncogene 1, receptor tyrosine kinase - HPRD,BioGRID 12475393
ARHGEF7 beta-pix |Cool1 |DKFZP686C12170 |DKFZP761K1021 |KIAA0142 |KIAA0412 |NBLA10314 |p50 |p50bp |P85 | P85COOL1 | P85SPR | PAK3 | PIXB Rho鸟嘌呤核苷酸交换因子（GEF）7 Two-hybrid Biogrid 12935897
BCR ALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHL 断点群集区域 共纯化 Biogrid 8641358
BLK MGC10442 B淋巴酪氨酸激酶 - HPRD 8083187
btk AGMX1 |在|ATK |bpk |IMD1 |MGC126261 |MGC126262 |PSCTK1 |XLA Bruton agammaglobulinemia tyrosine kinase - HPRD,BioGRID 7629518|10427990
CD19 B4 | MGC12802 CD19molecule - HPRD 9178909
CD2AP CMS | DKFZp586H0519 CD2-associated protein CMS interacts with Cbl. This interaction was modeled on a demonstrated interaction between CMS from an unspecified species and human Cbl. BIND 15128873
CD2AP CMS | DKFZp586H0519 CD2-associated protein - HPRD,BioGRID 11067845
CD5 leu1 |T1 CD5 molecule - HPRD,BioGRID 9603468
CDKL2 KKIAMRE | P56 cyclin-dependent kinase-like 2 (CDC2-related kinase) - HPRD 7721825
CRK CRKII v-crk sarcoma virus CT10 oncogene homolog (avian) 亲和力捕获 - 韦斯特恩 Biogrid 9178909|9461587
CRK CRKII v-crk sarcoma virus CT10 oncogene homolog (avian) - HPRD 8621483|8662998
CRKL - v-crk sarcoma virus CT10 oncogene homolog (avian)-like 亲和力捕获 - 韦斯特恩
重构的复合物		 Biogrid 9092574|9162067
|9344843|9461587
|9590251|9820532
|10204582|10907644
|11133830|12244174
CRKL - v-crk sarcoma virus CT10 oncogene homolog (avian)-like - HPRD 9162067|9590251
|12244174
CSF1R C-FMS | CD115 | CSFR | FIM2 | FMS colony stimulating factor 1 receptor - HPRD,BioGRID 11847211
CSK MGC117393 c-src tyrosine kinase - HPRD,BioGRID 11149930
egfr ERBB | ERBB1 | HER1 | PIG61 | mENA 表皮生长因子受体（红细胞性白血病病毒（V-ERB-B）癌基因同源物，鸟类） 亲和力捕获 - 韦斯特恩 Biogrid 10086340|12061819
egfr ERBB | ERBB1 | HER1 | PIG61 | mENA 表皮生长因子受体（红细胞性白血病病毒（V-ERB-B）癌基因同源物，鸟类） - HPRD 8662998
egfr ERBB | ERBB1 | HER1 | PIG61 | mENA 表皮生长因子受体（红细胞性白血病病毒（V-ERB-B）癌基因同源物，鸟类） An unspecified isoform of EGFR interacts with CBL. BIND 15735736
egfr ERBB | ERBB1 | HER1 | PIG61 | mENA 表皮生长因子受体（红细胞性白血病病毒（V-ERB-B）癌基因同源物，鸟类） c-Cbl ubiquitinates an unspecified isoform of EGFR. This interaction was modeled on a demonstrated interaction between c-Cbl and EGFR, both from an unspecified species. BIND 12234920
EPHB6 HEP | MGC129910 | MGC129911 EPH receptor B6 - HPRD 11713248
FGR FLJ43153 |MGC75096 |src2 |C-FGR |C-SRC2 |p55c-fgr |p58c-fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog - HPRD,BioGRID 12435267
FLOT1 - 鞭毛素1 - HPRD,BioGRID 11001060
FRS2 FRS2A | FRS2alpha | SNT | SNT-1 | SNT1 fibroblast growth factor receptor substrate 2 - HPRD,BioGRID 11997436
Fyn MGC45350 | SLK | SYN Fynoncogene related to SRC, FGR, YES - HPRD,BioGRID 9535867
GRB2 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 growth factor receptor-bound protein 2 Grb2 interacts with Cbl. BIND 15782196
GRB2 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 growth factor receptor-bound protein 2 c-Cbl interacts with Grb2. This interaction was modeled on a demonstrated interaction between human c-Cbl and Grb2 from an unspecified species. BIND 11053437
GRB2 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 growth factor receptor-bound protein 2 亲和力捕获 - 韦斯特恩
重构的复合物
Two-hybrid		 Biogrid 8083187|9108392
|9174058|9178909
|9367879|9461587
|9872323|10086340
|10204582|10570290
|11964172|11997436
GRB2 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 growth factor receptor-bound protein 2 - HPRD 9108392|9178909
|11133830|11964172
HCK JTK9 血压细胞激酶 - HPRD,BioGRID 10092522
INPPL1 Ship2 inositol polyphosphate phosphatase-like 1 - HPRD,BioGRID 12504111
ITK EMT |lyk |MGC126257 |MGC126258 |PSCTK2 IL2-inducible T-cell kinase - HPRD,BioGRID 8810341
KRT18 CYK18 | K18 keratin 18 C-CBL与角蛋白18相互作用。 BIND 9367879
KRT18 CYK18 | K18 keratin 18 - HPRD,BioGRID 9367879
LCK yt16 |p56lck |pp58lck lymphocyte-specific protein tyrosine kinase - HPRD,BioGRID 9178909|11741956
|11904433
LCP2 SLP-76 |SLP76 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) - HPRD,BioGRID 10204582
LTK TYK1 leukocyte receptor tyrosine kinase - HPRD,BioGRID 9223670
林恩 FLJ26625 | JTK8 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 亲和力捕获 - 韦斯特恩 Biogrid 12244174
林恩 FLJ26625 | JTK8 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog - HPRD 12149655
见面 auts9 |HGFR |RCCP2 |C-MET met proto-oncogene (hepatocyte growth factor receptor) Met interacts with Cbl. BIND 11894096
见面 auts9 |HGFR |RCCP2 |C-MET met proto-oncogene (hepatocyte growth factor receptor) - HPRD,BioGRID 11894096
myo1c FLJ23903 | MMI-beta | MMIb | NMI | myr2 myosin IC Two-hybrid Biogrid 9367879
NCK1 MGC12668 |NCK |nckalpha NCK adaptor protein 1 亲和力捕获 - 韦斯特恩 Biogrid 10204582|11494134
OSTF1 FLJ20559 | OSF | SH3P2 | bA235O14.1 osteoclast stimulating factor 1 Cbl interacts with SH3P2. BIND 15135048
PDGFRA CD140A |MGC74795 |PDGFR2 |Rhe-pdgfra platelet-derived growth factor receptor, alpha polypeptide 亲和力捕获 - 韦斯特恩
重构的复合物		 Biogrid 9234717
PDGFRB CD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1 platelet-derived growth factor receptor, beta polypeptide c-Cbl互动以及ubiquitinates PDGF-R-beta. This interaction was modeled on a demonstrated interaction between human c-Cbl and PDGF-R-beta from an unspecified species. BIND 10514377
PIK3CA MGC142161 | MGC142163 | PI3K | p110-alpha phosphoinositide-3-kinase, catalytic, alpha polypeptide 共纯化 Biogrid 8641358
PIK3R1 GRB1 | p85 | p85-ALPHA 磷酸肌醇3-激酶，调节亚基1（alpha） 亲和力捕获 - 韦斯特恩 Biogrid 9461587|9918857
PIK3R2 P85B |P85 |p85-beta 磷酸肌醇3-激酶，调节亚基2（beta） - HPRD,BioGRID 7629144
PLCG1 PLC-II |PLC1 |PLC148 |Plcgamma1 phospholipase C, gamma 1 - HPRD,BioGRID 9712732|12061819
PTK2B CADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTK PTK2B protein tyrosine kinase 2 beta - HPRD,BioGRID 11149930
PTPN22 LYP | Lyp1 | Lyp2 | PEP | PTPN8 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) - HPRD 10068674
PTPN6 HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1 protein tyrosine phosphatase, non-receptor type 6 - HPRD,BioGRID 12176909
PXN FLJ16691 paxillin 共纯化 Biogrid 8641358
RET CDHF12 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1 | RET51 ret原癌基因 - HPRD 12727845
SH2B2 APS SH2B adaptor protein 2 重构的复合物 Biogrid 10374881
SH3BP2 3BP2 |CRBM |CRPM |FLJ42079 |RES4-23 SH3-domain binding protein 2 重构的复合物 Biogrid 9846481
SH3GL2 CNSA2 | EEN-B1 | FLJ20276 | FLJ25015 | SH3D2A | SH3P4 SH3-domain GRB2-like 2 - HPRD 11894096
SH3GL2 CNSA2 | EEN-B1 | FLJ20276 | FLJ25015 | SH3D2A | SH3P4 SH3-domain GRB2-like 2 亲和力捕获 - 韦斯特恩 Biogrid 11894095
SH3GL3 CNSA3 |een-2b-l3 |een-b2 |HST19371 |SH3D2C |SH3P13 SH3-domain GRB2-like 3 - HPRD,BioGRID 11894096
SH3KBP1 CIN85 | GIG10 | MIG18 SH3-domain kinase binding protein 1 - HPRD,BioGRID 11894095
SH3KBP1 CIN85 | GIG10 | MIG18 SH3-domain kinase binding protein 1 CIN85与CBL相互作用。 BIND 11894095
SHC1 FLJ26504 | SHC | SHCA SHC（SRC同源性2结构域）转化蛋白1 - HPRD,BioGRID 10570290
SLA Sla1 |拍击 类似于SRC的适应器 - HPRD,BioGRID 10449770
Sla2 C20orf156 | FLJ21992 | MGC49845 | SLAP-2 | SLAP2 类似于SRC的适应器2 - HPRD,BioGRID 11891219|12024036
SORBS1 上限|DKFZP451C066 |DKFZP586P1422 |flaf2 |FLJ12406 |KIAA1296 |R85FL |SH3D5 |SH3P12 |Sorb1 sorbin and SH3 domain containing 1 - HPRD 11001060
SORBS1 上限|DKFZP451C066 |DKFZP586P1422 |flaf2 |FLJ12406 |KIAA1296 |R85FL |SH3D5 |SH3P12 |Sorb1 sorbin and SH3 domain containing 1 亲和力捕获 - 韦斯特恩 Biogrid 12504111|15128873
SORBS1 上限|DKFZP451C066 |DKFZP586P1422 |flaf2 |FLJ12406 |KIAA1296 |R85FL |SH3D5 |SH3P12 |Sorb1 sorbin and SH3 domain containing 1 CAP的未指定同工型与CBL相互作用。这种相互作用是在未指定物种和人CBL的CAP之间的相互作用上建模的。 BIND 15128873
SORBS2 ARGBP2 | FLJ93447 | KIAA0777 | PRO0618 sorbin and SH3 domain containing 2 亲和力捕获 - 韦斯特恩
重构的复合物
Two-hybrid		 Biogrid 12475393|15128873
SORBS2 ARGBP2 | FLJ93447 | KIAA0777 | PRO0618 sorbin and SH3 domain containing 2 ArgBP2 interacts with Cbl. BIND 15128873
SORBS2 ARGBP2 | FLJ93447 | KIAA0777 | PRO0618 sorbin and SH3 domain containing 2 ARGBP2-A与CBL相互作用。 BIND 12475393
SPRY2 MGC23039 | hSPRY2 sprouty homolog 2 (Drosophila) - HPRD,BioGRID 11053437|12234920
SPRY2 MGC23039 | hSPRY2 sprouty homolog 2 (Drosophila) c-Cbl interacts with hSpry2. This interaction was modeled on a demonstrated interaction between c-Cbl from an unspecified species and human hSpry2. BIND 12234920
SPRY2 MGC23039 | hSPRY2 sprouty homolog 2 (Drosophila) SPRY2与C-CBL相互作用。 BIND 11053437
SPRY2 MGC23039 | hSPRY2 sprouty homolog 2 (Drosophila) hSpry2 interacts with c-Cbl. BIND 12815057
src ASV | SRC1 | c-SRC | p60-Src V-SRC肉瘤（Schmidt-Ruppin A-2）病毒癌基因同源物（Avian） - HPRD 8635998
src ASV | SRC1 | c-SRC | p60-Src V-SRC肉瘤（Schmidt-Ruppin A-2）病毒癌基因同源物（Avian） CBL与SRC相互作用。这种相互作用是基于未指定物种的人类CBL和SRC之间的相互作用进行建模的。 BIND 15135048
SYK DKFZp313N1010 | FLJ25043 | FLJ37489 脾酪氨酸激酶 亲和力捕获 - 韦斯特恩
重构的复合物		 Biogrid 9857068|11331248
|12435267
SYK DKFZp313N1010 | FLJ25043 | FLJ37489 脾酪氨酸激酶 - HPRD 9857068|10540342
|11133830
TLN1 ilweq |KIAA1027 |TLN talin 1 共纯化 Biogrid 8641358
TYK2 JTK1 酪氨酸激酶2 亲和力捕获 - 韦斯特恩 Biogrid 8780698
ubash3b KIAA1959 |MGC15437 |STS-1 |sts1 |P70 ubiquitin associated and SH3 domain containing, B - HPRD 15159412
ube2d2 E2(17)KB2 | PUBC1 | UBC4 | UBC4/5 | UBCH5B ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) - HPRD,BioGRID 10514377
ube2d2 E2(17)KB2 | PUBC1 | UBC4 | UBC4/5 | UBCH5B ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) C-CBL与UBC4相互作用。 BIND 10514377
ube2g1 E217K |UBC7 |ube2g 泛素结合酶E2G 1（UBC7同源物，酵母） - HPRD 11032556
ube2g2 UBC7 ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) - HPRD 11032556
ube2l3 E2-F1 | L-UBC | UBCH7 | UbcM4 泛素结合酶E2L 3 亲和力捕获 - 韦斯特恩
共晶结构
重构的复合物		 Biogrid 10531381|10966114
|12234920
ube2l3 E2-F1 | L-UBC | UBCH7 | UbcM4 泛素结合酶E2L 3 - HPRD 10531381|10966114
|11278816
ube2l3 E2-F1 | L-UBC | UBCH7 | UbcM4 泛素结合酶E2L 3 C-CBL与UBCH7的未指定同工型相互作用。这种相互作用是基于未指定物种与人类UBCH7的C-CBL之间的相互作用进行建模的。 BIND 12234920
VAV1 VAV VAV 1鸟嘌呤核苷酸交换因子 - HPRD 9200440|11133830
VAV1 VAV VAV 1鸟嘌呤核苷酸交换因子 亲和力捕获 - 韦斯特恩
Far Western
重构的复合物		 Biogrid 9200440|11331248
VAV2 - vav 2 guanine nucleotide exchange factor - HPRD 11313921
YWHAB GW128 |HS1 |KCIP-1 酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，β多肽 C-CBL与14-3-3-beta相互作用。 BIND 9367879
YWHAB GW128 |HS1 |KCIP-1 酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，β多肽 亲和力捕获 - 韦斯特恩
重构的复合物
Two-hybrid		 Biogrid 9367879
YWHAQ 14-3-3 |1c5 |HS1 酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，theta多肽 - HPRD,BioGRID 8663231|11024037
YWHAZ KCIP-1|MGC111427 | MGC126532 | MGC138156 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide Two-hybrid Biogrid 9367879
YWHAZ KCIP-1|MGC111427 | MGC126532 | MGC138156 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide c-Cbl interacts with 14-3-3-zeta. BIND 9367879
ZAP70 FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70 zeta-chain (TCR) associated protein kinase 70kDa 亲和力捕获 - 韦斯特恩
共晶结构		 Biogrid 8798643|10078535


Section V. Pathway annotation

Pathway name 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG ERBB SIGNALING PATHWAY 87 71 All SZGR 2.0 genes in this pathway
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 138 98 All SZGR 2.0 genes in this pathway
KEGG内吞作用 183 132 All SZGR 2.0 genes in this pathway
kegg jak stat信号通路 155 105 All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG慢性髓细胞性白血病 73 59 All SZGR 2.0 genes in this pathway
BIOCARTA CBL PATHWAY 13 10 All SZGR 2.0 genes in this pathway
BIOCARTA IL2RB PATHWAY 38 26 All SZGR 2.0 genes in this pathway
Biocarta Spry途径 18 15 All SZGR 2.0 genes in this pathway
心肌细胞中的SIG胰岛素受体途径 51 41 All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION 45 33 All SZGR 2.0 genes in this pathway
PID FCER1 PATHWAY 62 43 All SZGR 2.0 genes in this pathway
PID INSULIN PATHWAY 45 32 All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY 59 49 All SZGR 2.0 genes in this pathway
PID IL4 2PATHWAY 65 43 All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 66 51 All SZGR 2.0 genes in this pathway
PID遇到了路径 80 60 All SZGR 2.0 genes in this pathway
PID REELIN PATHWAY 29 29 All SZGR 2.0 genes in this pathway
PID CDC42途径 70 51 All SZGR 2.0 genes in this pathway
PID CD8 TCR途径 53 42 All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY 75 53 All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY 40 34 All SZGR 2.0 genes in this pathway
PID EPHA FWDPATHWAY 34 29 All SZGR 2.0 genes in this pathway
PID PDGFRB途径 129 103 All SZGR 2.0 genes in this pathway
PID IL8 CXCR2 PATHWAY 34 26 All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY 41 35 All SZGR 2.0 genes in this pathway
PID VEGFR1途径 26 23 All SZGR 2.0 genes in this pathway
PID KIT PATHWAY 52 40 All SZGR 2.0 genes in this pathway
PID EPO PATHWAY 34 29 All SZGR 2.0 genes in this pathway
PID VEGFR1 2途径 69 57 All SZGR 2.0 genes in this pathway
PID IL8 CXCR1 PATHWAY 28 19 All SZGR 2.0 genes in this pathway
PID EPHA2 FWD途径 19 16 All SZGR 2.0 genes in this pathway
PID FGF PATHWAY 55 37 All SZGR 2.0 genes in this pathway
SCF套件的Reactome信号传导 78 59 All SZGR 2.0 genes in this pathway
REACTOME SPRY REGULATION OF FGF SIGNALING 14 9 All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING 37 24 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF KIT SIGNALING 17 10 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR 18 13 All SZGR 2.0 genes in this pathway
EGFR在癌症中的反应组信号传导 109 80 All SZGR 2.0 genes in this pathway
Reactome抗原激活B细胞受体，导致第二使者产生 29 24 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 126 90 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
REACTOME EGFR DOWNREGULATION 25 14 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 107 86 All SZGR 2.0 genes in this pathway
CBL对信号的反应组调节 18 16 All SZGR 2.0 genes in this pathway
REACTOME IL 3 5 AND GM CSF SIGNALING 43 34 All SZGR 2.0 genes in this pathway
REACTOME IL 6 SIGNALING 11 9 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270 204 All SZGR 2.0 genes in this pathway
FGFR的Reactome信号传导 112 80 All SZGR 2.0 genes in this pathway
Rodrigues NTN1靶向DN 158 102 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 23 24 13 All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向胎儿肝DN 514 319 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357 212 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
Hedenfalk乳腺癌BRCA1与BRCA2 163 113 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323 240 All SZGR 2.0 genes in this pathway
LEE RECENT THYMIC EMIGRANT 227 128 All SZGR 2.0 genes in this pathway
fontaine乳头状甲状腺癌DN 80 53 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321 200 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN 106 77 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
Let-7/98 3440 3447 1A,m8 hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain ugagguaguagguuguguguguu
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
HSA-MIR-98brain ugagguaaguuguauuguu
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain ugagguaguugugugugugcugu
hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain ugagguaguagguuguguguguu
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
HSA-MIR-98brain ugagguaaguuguauuguu
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain ugagguaguugugugugugcugu
miR-1/206 914 921 1A,m8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ Uggaauguaaggaagugugugg
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
mir-101 763 769 m8 hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-124/506 7186 7192 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
miR-133 3362 3368 m8 HSA-MIR-133A uugguccccuucaaccagcugu
HSA-MIR-133B UUGGUCCCCUUCAACCAGCUA
miR-141/200a 8015 8022 1A,m8 HSA-MIR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-150 3871 3877 1A HSA-MIR-150 UCUCCCAACCCUUGUACCAGUG
mir-192/215 985 991 m8 HSA-MIR-192 CUGACCUAUGAAUUGACAGCC
hsa-miR-215 AUGACCUAUGAAUUGACAGAC
miR-199 808 814 m8 hsa-miR-199a CCCAGUGUUCAGACUACCUGUUC
hsa-miR-199b CCCAGUGUUUAGACUAUCUGUUC
miR-214 7025 7032 1A,m8 hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-218 450 456 1A hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-22 7051 7058 1A,m8 hsa-miR-22brain AAGCUGCCAGUUGAAGAACUGU
mir-221/222 8360 8366 1A hsa-miR-221brain agcuacauugucugugggggguc
hsa-miR-222brain agcuacaucuggcuacugggucuc
miR-30-3p 7157 7164 1A,m8 HSA-MIR-30A-3P CUUUCAGUCGGAUGUUUGCAGC
HSA-MIR-30E-3P CUUUCAGUCGGAUGUUUACAGC
mir-320 8177 8183 1A hsa-miR-320 aaaagcugggugagaggggcgaa
mir-330 3857 3863 1A hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
mir-338 7619 7625 1A hsa-miR-338brain uccagauuuuuguuga
miR-374 404 410 1A HSA-MIR-374 UUAUAAUACAACCUGAUAAGUG
miR-381 8007 8013 1A HSA-MIR-381 UAUACAAGGGCAAGCUCUCUGU
miR-410 7112 7118 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-495 734 740 m8 hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-542-3p 4125 4131 m8 hsa-miR-542-3p UGUGACAGAUUGAUAACUGAAA
mir-543 8251 8257 1A hsa-miR-543 aaacauucgcggugcacuucu
mir-9 6138 6144 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA