Gene Page:CBLB

Summary？
基因 868
象征 CBLB
Synonyms CBL-B | NBLA00127 | RNF56
Description CBL原癌基因B，E3泛素蛋白连接酶
Reference MIM:604491|HGNC：HGNC：1542|Ensembl:ENSG00000114423|HPRD：05136|Vega：Otthumg00000150654
基因类型 蛋白质编码
Map location 3Q13.11
Pascal p-value 0.033
Sherlock p-value 0.612
胎儿β 2.144
DMG 1(# studies)
主持人 小脑
Myers' cis & trans
元

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
DMG：Nishioka_2013 全基因组DNA甲基化分析 作者研究了来自18例第一期精神分裂症（FESZ）和15个正常对照的18例外周血细胞中DNA的甲基化谱。 1
gsma_iie Genome scan meta-analysis (European-ancestry samples) PSR：0.04359
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.04047

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe 染色体 位置 Nearest gene p（dis） Beta (dis) fdr（dis） 学习
cg17468841 3 105588020 CBLB -0.026 0.25 DMG：Nishioka_2013

@eQTL annotation

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
RS17392743 CHR1 54764240 CBLB 868 0.15 反式
RS17572651 CHR1 218943612 CBLB 868 0.07 反式
RS16829545 CHR2 151977407 CBLB 868 4.454e-16 反式
rs3845734 CHR2 171125572 CBLB 868 0.11 反式
RS7584986 CHR2 184111432 CBLB 868 4.573E-5 反式
RS9810143 CHR3 5060209 CBLB 868 0.18 反式
RS6797307 CHR3 8601563 CBLB 868 0.17 反式
RS16860529 CHR3 185900368 CBLB 868 0.06 反式
rs7727026 CHR5 3456152 CBLB 868 0.1 反式
RS2914204 CHR5 3470913 CBLB 868 0.16 反式
rs13360496 0 CBLB 868 0.09 反式
rs16890367 CHR6 38078448 CBLB 868 0.05 反式
rs11139334 Chr9 84209393 CBLB 868 0 反式
rs3765543 Chr9 134458323 CBLB 868 0.15 反式
rs2393316 chr10 59333070 CBLB 868 0.02 反式
rs16955618 CHR15 29937543 CBLB 868 1.128E-22 反式
RS11873184 CHR18 1584081 CBLB 868 0.09 反式
RS7274477 CHR20 1676942 CBLB 868 0.13 反式
RS1041786 CHR21 22617710 CBLB 868 0 反式
RS16990575 Chrx 32691327 CBLB 868 0.07 反式

第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0004871 信号传感器活性 IEA -
去：0005509 calcium ion binding IEA -
去：0005515 蛋白质结合 TAS 7784085
GO：0016874 ligase activity IEA -
GO:0008270 锌离子结合 TAS 7784085
生物过程 去学期 证据 神经关键字 PubMed ID
去：0006511 ubiquitin-dependent protein catabolic process IEA -
GO:0007242 细胞内信号传导级联 IEA -
GO:0007166 cell surface receptor linked signal transduction IEA -
去：0006607 NLS-bearing substrate import into nucleus TAS 7784085
去：0006955 免疫反应 IEA -
GO:0042110 T细胞激活 IEA -
GO:0050860 negative regulation of T cell receptor signaling pathway IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005634 nucleus IEA -
去：0005737 cytoplasm IEA -

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
BLNK bash |blnk-s |Ly57 |MGC111051 |SLP-65 |SLP65 B细胞链接器 - HPRD 12093870
BTK AGMX1 |在|ATK |bpk |IMD1 |MGC126261 |MGC126262 |PSCTK1 |XLA 布鲁顿阿氨基葡萄糖酸酪氨酸激酶 亲和力捕获 - 韦斯特恩 Biogrid 12093870
CRKL - v-crk sarcoma virus CT10 oncogene homolog (avian)-like - HPRD,BioGRID 10022120
CRY1 PHLL1 cryptochrome 1 (photolyase-like) Two-hybrid Biogrid 16189514
egfr ERBB |ERBB1 |her1 |PIG61 |梅纳 表皮生长因子受体（红细胞性白血病病毒（V-ERB-B）癌基因同源物，鸟类） - HPRD,BioGRID 10086340
flt3 CD135 | FLK2 | STK1 与FMS相关的酪氨酸激酶3 - HPRD 9614102
GORASP2 DKFZP434D156 |FLJ13139 |Golph6 |grasp55 |grs2 |P59 golgi reassembly stacking protein 2, 55kDa Two-hybrid Biogrid 16189514
GRB2 灰烬|EGFRBP-GRB2 |Grb3-3 |MST084 |MSTP084 生长因子受体结合蛋白2 - HPRD,BioGRID 10086340
KIT c-kit |CD117 |PBT |scfr V-Kit Hardy-Zuckerman 4猫肉瘤病毒性癌基因同源物 亲和力捕获 - 韦斯特恩 Biogrid 12177062
NCK2 grb4 |NCKBETA NCK adaptor protein 2 Two-hybrid Biogrid 16189514
NEDD4 KIAA0093 | MGC176705 | NEDD4-1 | RPF1 神经前体细胞表达，发育下调4 - HPRD,BioGRID 12907674
PIK3R1 GRB1 | p85 | p85-ALPHA 磷酸肌醇3-激酶，调节亚基1（alpha） 亲和力捕获 - 韦斯特恩 Biogrid 9614102
PLCG2 - phospholipase C, gamma 2 (phosphatidylinositol-specific) - HPRD,BioGRID 12093870
SH3KBP1 CIN85 | GIG10 | MIG18 SH3核蛋白激酶结合蛋白1 - HPRD,BioGRID 12218189
SHC1 FLJ26504 | SHC | SHCA SHC（SRC同源性2结构域）转化蛋白1 - HPRD,BioGRID 9614102
SORBS3 骗局1 |Scam1 |SH3D4 |葡萄蛋白 索尔宾和SH3域，包含3个 Two-hybrid Biogrid 16189514
SPRY2 MGC23039 |Hspry2 发芽的同源物2（果蝇） SPRY2 interacts with Cbl-b. 绑定 11053437
VAV1 VAV VAV 1鸟嘌呤核苷酸交换因子 - HPRD,BioGRID 11857085
ZAP70 FLJ17670 |FLJ17679 |SRK |std |tzk |ZAP-70 Zeta链（TCR）相关蛋白激酶70KDA - HPRD,BioGRID 10074432


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG ERBB SIGNALING PATHWAY 87 71 All SZGR 2.0 genes in this pathway
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 138 98 All SZGR 2.0 genes in this pathway
KEGG内吞作用 183 132 All SZGR 2.0 genes in this pathway
kegg jak stat信号通路 155 105 All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
癌症中的KEGG途径 328 259 All SZGR 2.0 genes in this pathway
KEGG慢性髓细胞性白血病 73 59 All SZGR 2.0 genes in this pathway
PID FCER1途径 62 43 All SZGR 2.0 genes in this pathway
PID CD40 PATHWAY 31 26 All SZGR 2.0 genes in this pathway
pid nfat tfpathway 47 39 All SZGR 2.0 genes in this pathway
PID ERBB1 INTERNALIZATION PATHWAY 41 35 All SZGR 2.0 genes in this pathway
Reactome抗原激活B细胞受体，导致第二使者产生 29 24 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 126 90 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
Reactome适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
Reactome I类MHC介导的抗原加工表现 251 156 All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212 129 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
渡边直肠癌放疗反应能力 108 67 All SZGR 2.0 genes in this pathway
Casorelli急性临时细胞白血病 177 110 All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN 240 171 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3公共DN 483 336 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 145 91 All SZGR 2.0 genes in this pathway
彭谷氨酰胺剥夺 38 25 All SZGR 2.0 genes in this pathway
挞挞VS PLASMABLAST浆细胞 398 262 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203 130 All SZGR 2.0 genes in this pathway
Ferrando T与MLL融合一起 87 67 All SZGR 2.0 genes in this pathway
Zhan多发性骨髓瘤CD1和CD2 UP 89 51 All SZGR 2.0 genes in this pathway
Browne HCMV感染10小时DN 56 37 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病 1691 1088 All SZGR 2.0 genes in this pathway
XU GH1外源目标 85 50 All SZGR 2.0 genes in this pathway
布朗HCMV INFECTION 18HR UP 178 111 All SZGR 2.0 genes in this pathway
布朗HCMV INFECTION 10HR UP 101 69 All SZGR 2.0 genes in this pathway
Dazard对UV NHEK DN的反应 318 220 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 All SZGR 2.0 genes in this pathway
贝尔德糖尿病性肾病DN 434 302 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280 183 All SZGR 2.0 genes in this pathway
布朗HCMV INFECTION 6HR DN 160 101 All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN 49 34 All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时的反应 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
Zheng由Foxp3绑定 491 310 All SZGR 2.0 genes in this pathway
Zheng Foxp3目标胸腺 196 137 All SZGR 2.0 genes in this pathway
Amundson Gamma辐射阻力 20 14 All SZGR 2.0 genes in this pathway
COATES MACROPHAGE M1 VS M2 DN 78 44 All SZGR 2.0 genes in this pathway
黄Foxa2靶向 45 28 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
Chung水泡细胞毒性 134 84 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245 159 All SZGR 2.0 genes in this pathway
Ruiz TNC目标 153 107 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR UP 101 65 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
ERBB2同工4的PEDERSEN转移4 110 66 All SZGR 2.0 genes in this pathway
wakabayashi脂肪生成pparg rxra绑定36小时 152 88 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-135 201 207 1A hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b Uauggcuuuucauuccuaugug
miR-181 643 650 1A，M8 HSA-MIR-181Abrain AACAUUCAACGCUGUCGGUGAGU
HSA-MIR-181BSZ AACAUUCAUUGCUGUCGGUGGG
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-27 273 279 1A HSA-MIR-27Abrain uucacaguggcuaaguuccgc
HSA-MIR-27Bbrain UUCACAGUGGCUAAGUUCUGC
mir-30-5p 291 298 1A，M8 HSA-MIR-30A-5P UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA