Gene Page:GALNT4

Summary?
GeneID 8693
Symbol GALNT4
Synonyms GALNAC-T4|GALNACT4
Description polypeptide N-acetylgalactosaminyltransferase 4
Reference MIM:603565|HGNC:HGNC:4126|Ensembl:ENSG00000257594|HPRD:09152|Vega:OTTHUMG00000166292
Gene type protein-coding
Map location 12q21.33
eGene Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Ambalavanan_2016 Whole Exome Sequencing This dataset includes 20 de novo mutations detected in 17 COS probands.

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
GALNT4 chr12 89917133 G A NM_001199781 p.(=) synonymous SNV Childhood-onset schizophrenia DNM:Ambalavanan_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2052828 chr12 89888789 GALNT4 8693 0 cis
rs7960289 chr12 89890589 GALNT4 8693 0.01 cis
rs7310515 chr12 89899626 GALNT4 8693 0 cis
rs7310238 chr12 89899701 GALNT4 8693 0 cis
rs7299172 chr12 89899851 GALNT4 8693 0 cis
rs10777181 chr12 89908626 GALNT4 8693 0 cis
rs10777182 chr12 89908690 GALNT4 8693 0 cis
rs10745505 chr12 89910683 GALNT4 8693 0.01 cis
rs10858907 chr12 89934559 GALNT4 8693 0.03 cis
rs10858908 chr12 89934656 GALNT4 8693 0.02 cis
rs2052828 chr12 89888789 GALNT4 8693 0.14 trans
rs7310515 chr12 89899626 GALNT4 8693 0.14 trans
rs7310238 chr12 89899701 GALNT4 8693 0.08 trans
rs7299172 chr12 89899851 GALNT4 8693 0.11 trans
rs10777181 chr12 89908626 GALNT4 8693 0.16 trans
rs10777182 chr12 89908690 GALNT4 8693 0.18 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),圣2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DYNC1LI1 0.94 0.93
CUL2 0.92 0.91
MRPL3 0.91 0.91
RAB1A 0.91 0.91
HMGCLL1 0.91 0.90
STRAP 0.90 0.89
FBXO3 0.90 0.90
AZIN1 0.90 0.89
PPHLN1 0.90 0.88
STX12 0.89 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.74 -0.74
AF347015.33 -0.74 -0.74
AF347015.8 -0.73 -0.74
AF347015.2 -0.72 -0.75
FXYD1 -0.72 -0.75
AF347015.27 -0.71 -0.73
MT-CYB -0.71 -0.72
AF347015.15 -0.71 -0.73
AF347015.31 -0.71 -0.72
AF347015.26 -0.70 -0.73

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG O GLYCAN BIOSYNTHESIS 30 16 All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN 90 65 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265 158 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 UP 137 84 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN THYMUS UP 196 137 All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS DN 70 44 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162 122 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP 289 184 All SZGR 2.0 genes in this pathway