Gene Page:TNFRSF25
Summary?
| GeneID | 8718 |
| Symbol | TNFRSF25 |
| Synonyms | APO-3|DDR3|DR3|LARD|TNFRSF12|TR3|TRAMP|WSL-1|WSL-LR |
| Description | tumor necrosis factor receptor superfamily member 25 |
| Reference | MIM:603366|HGNC:HGNC:11910|Ensembl:ENSG00000215788|HPRD:04532|Vega:OTTHUMG00000000831 |
| Gene type | protein-coding |
| Map location | 1p36.2 |
| Pascal p-value | 0.012 |
| Sherlock p-value | 0.379 |
| eGene | Myers' cis & trans 元 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Expression | 元-analysis of gene expression | Pvalue: 1.362 |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2502827 | chr1 | 176044216 | TNFRSF25 | 8718 | 0.04 | trans | ||
| rs12405921 | chr1 | 206695730 | TNFRSF25 | 8718 | 0.03 | trans | ||
| rs16829545 | chr2 | 151977407 | TNFRSF25 | 8718 | 0.01 | trans | ||
| rs3845734 | chr2 | 171125572 | TNFRSF25 | 8718 | 0 | trans | ||
| rs7584986 | chr2 | 184111432 | TNFRSF25 | 8718 | 2.308E-4 | trans | ||
| rs17762315 | chr5 | 76807576 | TNFRSF25 | 8718 | 0.14 | trans | ||
| rs1368303 | chr5 | 147672388 | TNFRSF25 | 8718 | 0.15 | trans | ||
| rs17104720 | chr14 | 77127308 | TNFRSF25 | 8718 | 0.02 | trans | ||
| rs6574467 | chr14 | 79179744 | TNFRSF25 | 8718 | 0.09 | trans | ||
| rs10146003 | chr14 | 79191170 | TNFRSF25 | 8718 | 0.09 | trans | ||
| rs16955618 | chr15 | 29937543 | TNFRSF25 | 8718 | 2.161E-11 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NRP2 | 0.66 | 0.55 |
| AL161668.2 | 0.65 | 0.58 |
| HEATR2 | 0.64 | 0.63 |
| ERBB2 | 0.64 | 0.60 |
| GYS1 | 0.63 | 0.62 |
| ATP10D | 0.63 | 0.61 |
| PALLD | 0.63 | 0.62 |
| DDR1 | 0.63 | 0.60 |
| SALL2 | 0.63 | 0.59 |
| PXN | 0.62 | 0.58 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.38 | -0.45 |
| AF347015.27 | -0.37 | -0.42 |
| AF347015.31 | -0.36 | -0.42 |
| C5orf53 | -0.34 | -0.37 |
| MT-CO2 | -0.34 | -0.40 |
| AF347015.8 | -0.34 | -0.40 |
| MT-ATP8 | -0.32 | -0.41 |
| SYCP3 | -0.32 | -0.35 |
| AL139819.3 | -0.31 | -0.39 |
| AF347015.33 | -0.30 | -0.35 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | NAS | 9114039 | |
| GO:0005031 | tumor necrosis factor receptor activity | TAS | 9052839 | |
| GO:0005515 | protein binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007166 | cell surface receptor linked signal transduction | TAS | 9052839 | |
| GO:0008624 | induction of apoptosis by extracellular signals | TAS | 8994832 | |
| GO:0042981 | regulation of apoptosis | NAS | 9114039 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005829 | cytosol | NAS | 9114039 | |
| GO:0005576 | extracellular region | IEA | - | |
| GO:0005886 | plasma membrane | IDA | 11911831 | |
| GO:0005887 | integral to plasma membrane | TAS | 9052839 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | 267 | 161 | All SZGR 2.0 genes in this pathway |
| BIOCARTA DEATH PATHWAY | 33 | 24 | All SZGR 2.0 genes in this pathway |
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | All SZGR 2.0 genes in this pathway |
| RODRIGUES NTN1 TARGETS DN | 158 | 102 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN | 180 | 101 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN | 126 | 86 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN MLL SIGNATURE 2 DN | 281 | 186 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 SIGNATURE 3 DN | 162 | 116 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE EPIDERMIS UP | 293 | 179 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS G UP | 238 | 135 | All SZGR 2.0 genes in this pathway |
| DARWICHE SKIN TUMOR PROMOTER DN | 185 | 115 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA RISK LOW UP | 162 | 104 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA RISK HIGH UP | 147 | 101 | All SZGR 2.0 genes in this pathway |
| DARWICHE SQUAMOUS CELL CARCINOMA DN | 181 | 107 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| WHITE NEUROBLASTOMA WITH 1P36.3 DELETION | 21 | 17 | All SZGR 2.0 genes in this pathway |
| SCHLESINGER METHYLATED DE NOVO IN CANCER | 88 | 64 | All SZGR 2.0 genes in this pathway |
| OKAWA NEUROBLASTOMA 1P36 31 DELETION | 22 | 19 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| ONDER CDH1 TARGETS 2 DN | 464 | 276 | All SZGR 2.0 genes in this pathway |
| ASTON MAJOR DEPRESSIVE DISORDER UP | 49 | 36 | All SZGR 2.0 genes in this pathway |
| SHIPP DLBCL VS FOLLICULAR LYMPHOMA DN | 45 | 28 | All SZGR 2.0 genes in this pathway |
| HOFMANN CELL LYMPHOMA DN | 39 | 29 | All SZGR 2.0 genes in this pathway |
| SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 2 | 50 | 34 | All SZGR 2.0 genes in this pathway |
| NATSUME RESPONSE TO INTERFERON BETA DN | 52 | 33 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY UP | 487 | 303 | All SZGR 2.0 genes in this pathway |
| HELLER SILENCED BY METHYLATION UP | 282 | 183 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER NORMAL LIKE UP | 476 | 285 | All SZGR 2.0 genes in this pathway |
| BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING | 510 | 309 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
| LEE EARLY T LYMPHOCYTE DN | 57 | 36 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | All SZGR 2.0 genes in this pathway |
| 迈斯纳大脑HCP H3 UNMETHYLATED | 37 | 21 | All SZGR 2.0 genes in this pathway |
| WOO LIVER CANCER RECURRENCE UP | 105 | 75 | All SZGR 2.0 genes in this pathway |
| ONO AML1 TARGETS DN | 41 | 25 | All SZGR 2.0 genes in this pathway |
| ONO FOXP3 TARGETS DN | 42 | 23 | All SZGR 2.0 genes in this pathway |
| LU EZH2 TARGETS DN | 414 | 237 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |