Gene Page:ADAM15
概括?
| 基因 | 8751 |
| Symbol | ADAM15 |
| Synonyms | MDC15 |
| Description | ADAM metallopeptidase domain 15 |
| Reference | MIM:605548|HGNC:HGNC:193|Ensembl:ENSG00000143537|HPRD:05674|Vega:OTTHUMG00000013898 |
| Gene type | protein-coding |
| Map location | 1q21.3 |
| Sherlock p-value | 1.106E-6 |
| Fetal beta | -0.749 |
| eGene | Cerebellar Hemisphere Myers' cis & trans |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.0235 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.00814 |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs12677942 | chr8 | 31539941 | ADAM15 | 8751 | 0.07 | trans | ||
| rs16878286 | chr8 | 31646175 | ADAM15 | 8751 | 0.13 | trans | ||
| rs16878317 | chr8 | 31657853 | ADAM15 | 8751 | 0.07 | trans | ||
| rs2176013 | chr12 | 128736907 | ADAM15 | 8751 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FZD1 | 0.68 | 0.72 |
| TNFRSF10B | 0.66 | 0.55 |
| TNFRSF19 | 0.66 | 0.73 |
| FZD7 | 0.64 | 0.65 |
| SNCAIP | 0.64 | 0.70 |
| COL5A1 | 0.64 | 0.50 |
| ADAMTS3 | 0.64 | 0.69 |
| SALL2 | 0.64 | 0.79 |
| ATP7B | 0.64 | 0.78 |
| CTNND1 | 0.63 | 0.78 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C5orf53 | -0.42 | -0.61 |
| AF347015.31 | -0.41 | -0.69 |
| MT-CO2 | -0.41 | -0.70 |
| AF347015.33 | -0.39 | -0.63 |
| AF347015.27 | -0.39 | -0.64 |
| FXYD1 | -0.39 | -0.63 |
| CXCL14 | -0.39 | -0.66 |
| IFI27 | -0.39 | -0.64 |
| HIGD1B | -0.38 | -0.67 |
| AF347015.8 | -0.38 | -0.66 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | 新闻学会 | 10531379 | |
| GO:0004222 | metalloendopeptidase activity | IEA | - | |
| GO:0008270 | zinc ion binding | IEA | - | |
| GO：0017124 | SH3 domain binding | 新闻学会 | 10531379 | |
| GO:0008233 | peptidase activity | IEA | - | |
| GO:0046872 | metal ion binding | IEA | - | |
| 生物过程 | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0007160 | 细胞 - 矩阵粘附 | TAS | 9516430 | |
| GO:0007155 | cell adhesion | NAS | 10531379 | |
| GO:0006508 | proteolysis | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| 去：0016020 | membrane | IEA | - | |
| GO：0016021 | integral to membrane | IEA | - | |
| GO：0016021 | integral to membrane | NAS | 10531379 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | - | HPRD | 11741929 |
| Fyn | MGC45350 | SLK | SYN | Fynoncogene related to SRC, FGR, YES | - | HPRD,BioGRID | 11741929 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD,BioGRID | 11741929 |
| HCK | JTK9 | hemopoietic cell kinase | - | HPRD,BioGRID | 11741929 |
| LCK | YT16 | p56lck | pp58lck | lymphocyte-specific protein tyrosine kinase | - | HPRD,BioGRID | 11741929 |
| MAD2L1 | HSMAD2 | MAD2 | MAD2 mitotic arrest deficient-like 1 (yeast) | Affinity Capture-Western | BioGRID | 11741929 |
| MAD2L2 | MAD2B | REV7 | MAD2 mitotic arrest deficient-like 2 (yeast) | 两个杂交 | BioGRID | 10527948 |
| SH3D19 | EBP | EVE1 | Kryn | MGC105136 | MGC118910 | MGC118911 | MGC118912 | MGC118913 | SH3P19 | SH3 domain containing 19 | An unspecified isoform of ADAM15 binds to Eve-1c. | BIND | 15280379 |
| SH3D19 | EBP | EVE1 | Kryn | MGC105136 | MGC118910 | MGC118911 | MGC118912 | MGC118913 | SH3P19 | SH3 domain containing 19 | An unspecified isoform of ADAM9 binds to Eve-1d. | BIND | 15280379 |
| SH3D19 | EBP | EVE1 | Kryn | MGC105136 | MGC118910 | MGC118911 | MGC118912 | MGC118913 | SH3P19 | SH3 domain containing 19 | - | HPRD | 15280379 |
| SH3GL2 | CNSA2 | EEN-B1 | FLJ20276 | FLJ25015 | SH3D2A | SH3P4 | SH3-domain GRB2-like 2 | Affinity Capture-Western Reconstituted Complex 两个杂交 |
BioGRID | 10531379 |
| SNX9 | MST155 | MSTP155 | SDP1 | SH3PX1 | SH3PXD3A | WISP | sorting nexin 9 | - | HPRD,BioGRID | 10531379 |
| 意大利面5 | DEEPEST | MAP126 | hMAP126 | sperm associated antigen 5 | - | HPRD | 10531379 |
| SRC | ASV | SRC1 | c-SRC | p60-Src | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | - | HPRD | 11741929 |
| TRIP13 | 16E1BP | thyroid hormone receptor interactor 13 | 两个杂交 | BioGRID | 16189514 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID INTEGRIN A9B1 PATHWAY | 25 | 18 | 该途径中的所有SZGR 2.0基因 |
| Pramoonjago Sox4靶向DN | 51 | 35 | 该途径中的所有SZGR 2.0基因 |
| LINDGREN BLADDER CANCER CLUSTER 1 DN | 378 | 231 | 该途径中的所有SZGR 2.0基因 |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | 该途径中的所有SZGR 2.0基因 |
| PATIL LIVER CANCER | 747 | 453 | 该途径中的所有SZGR 2.0基因 |
| RICKMAN METASTASIS DN | 261 | 155 | 该途径中的所有SZGR 2.0基因 |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | 该途径中的所有SZGR 2.0基因 |
| NIKOLSKY BREAST CANCER 1Q21 AMPLICON | 38 | 18 | 该途径中的所有SZGR 2.0基因 |
| FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP | 87 | 58 | 该途径中的所有SZGR 2.0基因 |
| KLEIN PRIMARY EFFUSION LYMPHOMA UP | 51 | 29 | 该途径中的所有SZGR 2.0基因 |
| WANG TARGETS OF MLL CBP FUSION UP | 44 | 26 | 该途径中的所有SZGR 2.0基因 |
| AFFAR YY1 TARGETS UP | 214 | 133 | 该途径中的所有SZGR 2.0基因 |
| BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN | 161 | 105 | 该途径中的所有SZGR 2.0基因 |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | 该途径中的所有SZGR 2.0基因 |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | 该途径中的所有SZGR 2.0基因 |
| STEARMAN LUNG CANCER EARLY VS LATE DN | 61 | 39 | 该途径中的所有SZGR 2.0基因 |
| HELLER HDAC TARGETS UP | 317 | 208 | 该途径中的所有SZGR 2.0基因 |
| ACEVEDO LIVER CANCER UP | 973 | 570 | 该途径中的所有SZGR 2.0基因 |
| Bonome卵巢癌的生存次优秀 | 510 | 309 | 该途径中的所有SZGR 2.0基因 |
| GRADE COLON CANCER UP | 871 | 505 | 该途径中的所有SZGR 2.0基因 |
| ZHANG TLX TARGETS 36HR UP | 221 | 150 | 该途径中的所有SZGR 2.0基因 |
| Han Satb1靶向 | 395 | 249 | 该途径中的所有SZGR 2.0基因 |
| YAGI AML WITH 11Q23 REARRANGED | 351 | 238 | 该途径中的所有SZGR 2.0基因 |
| KESHELAVA MULTIPLE DRUG RESISTANCE | 88 | 56 | 该途径中的所有SZGR 2.0基因 |
| HOSHIDA LIVER CANCER SUBCLASS S1 | 237 | 159 | 该途径中的所有SZGR 2.0基因 |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 16 | 79 | 47 | 该途径中的所有SZGR 2.0基因 |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | 该途径中的所有SZGR 2.0基因 |
| JUBAN TARGETS OF SPI1 AND FLI1 UP | 115 | 73 | 该途径中的所有SZGR 2.0基因 |
| NABA ECM REGULATORS | 238 | 125 | 该途径中的所有SZGR 2.0基因 |
| NABA MATRISOME ASSOCIATED | 753 | 411 | 该途径中的所有SZGR 2.0基因 |
| NABA MATRISOME | 1028 | 559 | 该途径中的所有SZGR 2.0基因 |