Gene Page:TNFRSF14

Summary?
GeneID 8764
Symbol TNFRSF14
Synonyms ATAR|CD270|HVEA|HVEM|LIGHTR|TR2
Description tumor necrosis factor receptor superfamily member 14
Reference MIM:602746|HGNC:HGNC:11912|Ensembl:ENSG00000157873|HPRD:04122|织女:奥特HUMG00000000792
Gene type protein-coding
Map location 1p36.32
Pascal p-value 0.005
Sherlock p-value 0.494
eGene Cerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9993882 chr4 183824780 TNFRSF14 8764 0.09 trans
rs10016530 chr4 183824983 TNFRSF14 8764 0.09 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NUP85 0.95 0.94
DAXX 0.93 0.92
VPS16A 0.93 0.93
BAT1 0.92 0.93
GTF3C5 0.92 0.92
PRCC 0.92 0.92
TRA2B 0.92 0.93
AP4M1 0.91 0.91
NOP56 0.91 0.92
GTF2H4 0.91 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.81 -0.86
MT-CO2 -0.81 -0.86
AF347015.27 -0.80 -0.86
AF347015.33 -0.79 -0.85
MT-CYB -0.79 -0.85
AF347015.8 -0.79 -0.86
AF347015.15 -0.76 -0.84
AF347015.2 -0.76 -0.86
AF347015.26 -0.74 -0.85
AIFM3 -0.74 -0.76

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CHD3 Mi-2a | Mi2-ALPHA | ZFH chromodomain helicase DNA binding protein 3 Two-hybrid BioGRID 16169070
GCN1L1 GCN1 | GCN1L | KIAA0219 GCN1 general control of amino-acid synthesis 1-like 1 (yeast) Affinity Capture-MS BioGRID 17353931
HDAC4 HA6116 | HD4 | HDAC-A | HDACA | KIAA0288 histone deacetylase 4 - HPRD 11463856
LTA LT | TNFB | TNFSF1 lymphotoxin alpha (TNF superfamily, member 1) - HPRD 9153189
NRIP1 FLJ77253 | RIP140 nuclear receptor interacting protein 1 - HPRD 9774688
P4HB DSI | ERBA2L | GIT | PDI | PDIA1 | PHDB | PO4DB | PO4HB | PROHB procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide Affinity Capture-MS BioGRID 17353931
PDIA6 ERP5 | P5 | TXNDC7 protein disulfide isomerase family A, member 6 Affinity Capture-MS BioGRID 17353931
SEC11A 1810012E07Rik | SEC11L1 | SPC18 | SPCS4A | sid2895 SEC11 homolog A (S. cerevisiae) Affinity Capture-MS BioGRID 17353931
TNFSF12-TNFSF13 TWE-PRIL TNFSF12-TNFSF13 readthrough transcript - HPRD 10706119
TNFSF13 APRIL | CD256 | TALL2 | TRDL-1 | UNQ383/PRO715 | ligand tumor necrosis factor (ligand) superfamily, member 13 Reconstituted Complex BioGRID 10706119
TNFSF14 CD258 | HVEML | LIGHT | LTg | TR2 tumor necrosis factor (ligand) superfamily, member 14 - HPRD,BioGRID 11390428
TRAF1 EBI6 | MGC:10353 TNF receptor-associated factor 1 - HPRD,BioGRID 9162022
TRAF2 MGC:45012 | TRAP | TRAP3 TNF receptor-associated factor 2 - HPRD,BioGRID 9153189|9162022
TRAF3 CAP-1 | CD40bp | CRAF1 | LAP1 TNF receptor-associated factor 3 - HPRD,BioGRID 9162022
TRAF5 MGC:39780 | RNF84 TNF receptor-associated factor 5 Affinity Capture-Western
Reconstituted Complex
Two-hybrid		 BioGRID 9153189|9162022
UGCGL1 FLJ23671 | FLJ23796 | HUGT1 UDP-glucose ceramide glucosyltransferase-like 1 Affinity Capture-MS BioGRID 17353931
VIM FLJ36605 vimentin Two-hybrid BioGRID 16169070


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 63 48 All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933 616 All SZGR 2.0 genes in this pathway
REACTOME适应性免疫系统 539 350 All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206 111 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
ODONNELL TARGETS OF MYC AND TFRC UP 83 50 All SZGR 2.0 genes in this pathway
ZEILSTRA CD44 TARGETS UP 7 5 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207 145 All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION DN 184 132 All SZGR 2.0 genes in this pathway
ABE VEGFA TARGETS 2HR 34 21 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR DN 101 70 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259 185 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF LCP WITH H3K4ME3 128 68 All SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO CISPLATIN 20 14 All SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO MITOMYCIN 19 11 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE 151 86 All SZGR 2.0 genes in this pathway