Gene Page:TNFRSF6B

Summary?
GeneID 8771
Symbol TNFRSF6B
Synonyms DCR3|DJ583P15.1.1|M68|M68E|TR6
Description tumor necrosis factor receptor superfamily member 6b
Reference MIM:603361|HGNC:HGNC:11921|Ensembl:ENSG00000243509|HPRD:04527|Vega:OTTHUMG00000143724
Gene type protein-coding
Map location 20q13.3
Pascal p-value 0.006
Sherlock p-value 0.858
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
Expression Meta-analysis of gene expression Pvalue: 1.556

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs11260821 chr1 16931642 TNFRSF6B 8771 0.18 trans
rs2842861 chr1 156172498 TNFRSF6B 8771 0.09 trans
rs890527 chr3 140774852 TNFRSF6B 8771 0.02 trans
rs16846456 chr3 172757337 TNFRSF6B 8771 0.05 trans
rs3900348 chr4 104509166 TNFRSF6B 8771 0.11 trans
rs4446310 chr4 104509230 TNFRSF6B 8771 0.15 trans
rs4580655 chr4 104529273 TNFRSF6B 8771 0.07 trans
rs1678893 chr5 31763244 TNFRSF6B 8771 0.17 trans
rs12524136 chr6 84935440 TNFRSF6B 8771 0.05 trans
rs10247386 chr7 69173543 TNFRSF6B 8771 0.17 trans
rs7807249 chr7 131615735 TNFRSF6B 8771 0.11 trans
rs9416364 chr10 56253021 TNFRSF6B 8771 0.03 trans
rs4303487 chr16 90033254 TNFRSF6B 8771 0.19 trans
rs16979927 chr20 55019249 TNFRSF6B 8771 0.15 trans
rs16982879 chrX 92924110 TNFRSF6B 8771 0.03 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26conception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AC008074.3 0.92 0.91
AFTPH 0.91 0.90
RABGEF1 0.90 0.89
RTN1 0.90 0.89
MAPK14 0.90 0.89
UBQLN1 0.90 0.87
CSRP2BP 0.90 0.87
UBE2Z 0.89 0.89
UBQLN2 0.89 0.87
EIF4ENIF1 0.89 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.79 -0.75
AF347015.31 -0.77 -0.74
AF347015.21 -0.76 -0.76
AF347015.8 -0.76 -0.74
MT-CYB -0.75 -0.71
FXYD1 -0.75 -0.73
AF347015.26 -0.74 -0.70
AF347015.33 -0.74 -0.69
HIGD1B -0.73 -0.73
AF347015.2 -0.73 -0.70

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity TAS 9872321
GO:0003676 nucleic acid binding IEA -
GO:0005515 protein binding 新闻学会 10318773
GO:0005524 ATP binding IEA -
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA -
GO:0008026 ATP-dependent helicase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process IEA -
GO:0006916 anti-apoptosis TAS 9872321
GO:0006915 apoptosis IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region IEA -
GO:0005625 soluble fraction TAS 9872321

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267 161 All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY 65 54 All SZGR 2.0 genes in this pathway
CHIN BREAST CANCER COPY NUMBER UP 27 18 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 20Q12 Q13 AMPLICON 149 76 All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP 89 61 All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242 159 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway