Gene Page:GALR2
Summary?
| GeneID | 8811 |
| Symbol | GALR2 |
| Synonyms | GAL2-R|GALNR2|GALR-2 |
| Description | galanin receptor 2 |
| Reference | MIM:603691|HGNC:HGNC:4133|Ensembl:ENSG00000182687|HPRD:04735|Vega:OTTHUMG00000167479 |
| Gene type | protein-coding |
| Map location | 17q25.3 |
| Pascal p-value | 0.477 |
| Fetal beta | 0.048 |
| eGene | Myers' cis & trans 元 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | 系统搜索PubMed的基因co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 2 |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs997135 | chr20 | 12330295 | GALR2 | 8811 | 0.19 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| WDR74 | 0.92 | 0.92 |
| ILKAP | 0.92 | 0.92 |
| RPAIN | 0.92 | 0.91 |
| MAF1 | 0.92 | 0.91 |
| EIF6 | 0.91 | 0.92 |
| USF1 | 0.91 | 0.91 |
| BCS1L | 0.90 | 0.90 |
| PPP4C | 0.90 | 0.91 |
| NGDN | 0.90 | 0.90 |
| WDR46 | 0.90 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.27 | -0.76 | -0.84 |
| AF347015.33 | -0.74 | -0.83 |
| AF347015.8 | -0.73 | -0.82 |
| MT-CO2 | -0.73 | -0.80 |
| AF347015.15 | -0.73 | -0.84 |
| AF347015.31 | -0.72 | -0.80 |
| MT-CYB | -0.72 | -0.81 |
| AF347015.2 | -0.71 | -0.84 |
| AF347015.26 | -0.70 | -0.83 |
| AF347015.9 | -0.67 | -0.80 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | IEA | - | |
| GO:0004966 | galanin receptor activity | TAS | 9480833 | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0007268 | synaptic transmission | TAS | neuron, Synap, Neurotransmitter (GO term level: 6) | 9832121 |
| GO:0031175 | neurite development | IEA | neuron, axon, neurite, dendrite (GO term level: 10) | - |
| GO:0007204 | elevation of cytosolic calcium ion concentration | TAS | 9685625 | |
| GO:0007188 | G-protein signaling, coupled to cAMP nucleotide second messenger | TAS | 9685625 | |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | IEA | - | |
| GO:0007631 | feeding behavior | TAS | 9480833 | |
| GO:0007611 | learning or memory | TAS | 9480833 | |
| GO:0007586 | digestion | TAS | 9832121 | |
| GO:0006936 | muscle contraction | TAS | 9480833 | |
| GO:0007275 | multicellular organismal development | TAS | 9480833 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0016021 | integral to membrane | TAS | 9480833 | |
| GO:0005886 | plasma membrane | TAS | 9480833 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | 188 | 108 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 305 | 177 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA I SIGNALLING EVENTS | 195 | 114 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR LIGAND BINDING | 408 | 246 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| PEREZ TP63 TARGETS | 355 | 243 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 AND TP63 TARGETS | 205 | 145 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| BENPORATH PRC2 TARGETS | 652 | 441 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON | 335 | 181 | All SZGR 2.0 genes in this pathway |
| CERVERA SDHB TARGETS 1 UP | 118 | 66 | All SZGR 2.0 genes in this pathway |
| YAUCH HEDGEHOG SIGNALING PARACRINE UP | 149 | 85 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME2 AND H3K27ME3 | 59 | 35 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME2 | 491 | 319 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 4 | 15 | 11 | All SZGR 2.0 genes in this pathway |
| QI HYPOXIA | 140 | 96 | All SZGR 2.0 genes in this pathway |