Gene Page:INPP4B

Summary?
GeneID 8821
Symbol INPP4B
Synonyms -
Description inositol polyphosphate-4-phosphatase type II B
Reference MIM:607494|HGNC:HGNC:6075|Ensembl:ENSG00000109452|HPRD:06322|Vega:OTTHUMG00000161341
Gene type protein-coding
Map location 4q31.21
Pascal p-value 0.016
Sherlock p-value 0.175
Fetal beta -2.181
DMG 2 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg03476007 4 143768727 INPP4B 3.794E-4 0.656 0.043 DMG:Wockner_2014
cg24759237 4 142956467 INPP4B 6.32E-8 0.014 1.57E-5 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs4740614 chr9 15554959 INPP4B 8821 0.03 trans
rs10962066 chr9 15555037 INPP4B 8821 0.01 trans
rs7873152 chr9 15555457 INPP4B 8821 0.01 trans
rs10962070 chr9 15566016 INPP4B 8821 0.08 trans
rs10481557 chr9 15604745 INPP4B 8821 0.06 trans
rs4741528 chr9 15655977 INPP4B 8821 0.02 trans
rs6474944 chr9 15670444 INPP4B 8821 0.01 trans
rs6474952 chr9 15711233 INPP4B 8821 0.01 trans
rs10756697 chr9 15728516 INPP4B 8821 0.06 trans
rs4740624 chr9 15753410 INPP4B 8821 0.17 trans
rs7019851 chr9 15769550 INPP4B 8821 0.03 trans
rs4146291 chr9 15783265 INPP4B 8821 0.06 trans
rs10756704 chr9 15783815 INPP4B 8821 0.05 trans
rs7032457 chr9 15826729 INPP4B 8821 0.03 trans
rs9407654 chr9 15829262 INPP4B 8821 0.04 trans
rs1891212 chr9 15900770 INPP4B 8821 0.03 trans
rs16919920 0 INPP4B 8821 0.17 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GLT8D1 0.77 0.74
C20orf12 0.76 0.79
ALG13 0.76 0.77
RRAGB 0.76 0.78
NRBP1 0.75 0.78
ARMCX2 0.75 0.78
PARP2 0.75 0.82
FSIP1 0.75 0.75
VPS33B 0.75 0.77
TPST1 0.74 0.70
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.67 -0.65
AF347015.8 -0.67 -0.66
AF347015.33 -0.67 -0.64
AF347015.27 -0.66 -0.66
AF347015.2 -0.66 -0.65
AF347015.31 -0.65 -0.64
AF347015.15 -0.65 -0.64
MT-CYB -0.65 -0.63
AF347015.26 -0.65 -0.66
AF347015.21 -0.62 -0.63

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG INOSITOL PHOSPHATE METABOLISM 54 42 All SZGR 2.0 genes in this pathway
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 76 56 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 12 8 All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198 112 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE 31 23 All SZGR 2.0 genes in this pathway
REACTOME PI METABOLISM 48 34 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478 302 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS DN 182 111 All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS UP 94 57 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 UP 112 72 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352 225 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR UP 85 54 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182 110 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194 122 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
STREICHER LSM1 TARGETS UP 44 34 All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207 128 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330 217 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330 215 All SZGR 2.0 genes in this pathway
YANAGIHARA ESX1 TARGETS 30 19 All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 UP 36 22 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382 224 All SZGR 2.0 genes in this pathway
LIN SILENCED BY TUMOR MICROENVIRONMENT 108 73 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN UP 86 61 All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS UP 84 51 All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP 78 56 All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION DN 184 132 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
GEORGANTAS HSC MARKERS 71 47 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491 310 All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN THYMUS UP 196 137 All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220 147 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE UP 97 61 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
LEE NAIVE T LYMPHOCYTE 19 10 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER DN 134 83 All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229 135 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297 194 All SZGR 2.0 genes in this pathway