Gene Page:ASAP2

Summary?
GeneID 8853
Symbol ASAP2
Synonyms AMAP2|CENTB3|DDEF2|PAG3|PAP|Pap-alpha|SHAG1
Description ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Reference MIM:603817|HGNC:HGNC:2721|Ensembl:ENSG00000151693|HPRD:04820|Vega:OTTHUMG00000117485
Gene type protein-coding
Map location 2p25|2p24
Pascal p-value 0.048
Sherlock p-value 0.576
TADA p-value 0.019
Fetal beta 0.579
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
DNM:Gulsuner_2013 Whole Exome Sequencing analysis 155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
ASAP2 chr2 9517076 G A NM_001135191
NM_003887		 p.596V>M
p.596V>M		 missense
missense		 Schizophrenia DNM:Gulsuner_2013

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg03424478 2 9346387 ASAP2 3.85E-8 -0.015 1.1E-5 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9368942 chr6 36566512 ASAP2 8853 0.12 trans
rs9366911 chr6 36589339 ASAP2 8853 0.07 trans
rs7972594 chr12 11724913 ASAP2 8853 0.2 trans
rs10491979 chr12 11727969 ASAP2 8853 0.2 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception凌晨ks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ZEB1 0.77 0.75
SPAG9 0.76 0.73
BMS1 0.75 0.73
HDLBP 0.75 0.73
ZNF664 0.75 0.69
LRBA 0.75 0.74
B3GALNT2 0.75 0.74
NBR1 0.74 0.73
CDYL 0.74 0.71
PDCD4 0.74 0.73
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.57 -0.47
C1orf54 -0.54 -0.48
VAMP5 -0.51 -0.45
IFI27 -0.50 -0.45
AF347015.31 -0.50 -0.45
IL32 -0.50 -0.46
MYL3 -0.49 -0.45
MT-CO2 -0.49 -0.43
SYCP3 -0.49 -0.38
ENHO -0.48 -0.49

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ARF1 - ADP-ribosylation factor 1 - HPRD 10022920|10749932
ARF5 - ADP-ribosylation factor 5 - HPRD 10022920|10749932
ARF6 DKFZp564M0264 ADP-ribosylation factor 6 - HPRD 10022920|10749932
ITSN1 ITSN | MGC134948 | MGC134949 | SH3D1A | SH3P17 intersectin 1 (SH3 domain protein) DDEF2 (AMAP2) interacts with an unspecified isoform of ITSN1 (Intersectin1). BIND 15719014
PACSIN3 SDPIII protein kinase C and casein kinase substrate in neurons 3 DDEF2 (AMAP2) interacts with PACSIN3. BIND 15719014
PTK2B CADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTK PTK2B protein tyrosine kinase 2 beta - HPRD,BioGRID 10022920
PXN FLJ16691 paxillin in vitro
Reconstituted Complex		 BioGRID 10749932|12149250
PXN FLJ16691 paxillin - HPRD 10749932|12149250
跑 ARA24 | Gsp1 | TC4 跑, member RAS oncogene family - HPRD 10022920
SH3KBP1 CIN85 | GIG10 | MIG18 SH3-domain激酶结合蛋白1 DDEF2 (AMAP2) interacts with SH3KBP1 (CIN85). BIND 15719014
SRC ASV | SRC1 | c-SRC | p60-Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) Affinity Capture-Western BioGRID 10022920
TBRG4 CPR2 | FASTKD4 | KIAA0948 transforming growth factor beta regulator 4 Affinity Capture-MS BioGRID 17353931


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG ENDOCYTOSIS 183 132 All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 97 71 All SZGR 2.0 genes in this pathway
BIOCARTA ARAP PATHWAY 18 13 All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY 49 34 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362 238 All SZGR 2.0 genes in this pathway
XU HGF SIGNALING NOT VIA AKT1 6HR 26 15 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP 78 56 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN 123 86 All SZGR 2.0 genes in this pathway
BILD SRC ONCOGENIC SIGNATURE 62 38 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP 176 110 All SZGR 2.0 genes in this pathway
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION UP 67 48 All SZGR 2.0 genes in this pathway
GYORFFY DOXORUBICIN RESISTANCE 56 34 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207 143 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213 127 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222 159 All SZGR 2.0 genes in this pathway