Gene Page:aldh1a2

概括?
基因 8854
象征 aldh1a2
Synonyms RALDH(II)|RALDH2|RALDH2-T
Description aldehyde dehydrogenase 1 family member A2
Reference MIM:603687|HGNC:HGNC:15472|Ensembl:ENSG00000128918|HPRD:04733|Vega:OTTHUMG00000132624
Gene type protein-coding
Map location 15q21.3
Pascal p-value 0.823
Sherlock p-value 0.335
Fetal beta -0.566
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统的搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophrenias 点击to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关关键字的命中：3

第一节遗传学和表观遗传学注释

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance EQTL类型
rs6693444 chr1 98690213 aldh1a2 8854 0.08 trans
rs16909877 chr9 98216644 aldh1a2 8854 0.12 trans
RS9303674 chr17 32458848 aldh1a2 8854 0.16 trans
rs12951337 chr17 58154206 aldh1a2 8854 0.09 trans
rs17255719 chrX 12144766 aldh1a2 8854 0.1 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SCYL1 0.90 0.87
GRINA 0.88 0.86
ATP6AP1 0.88 0.88
C3orf39 0.87 0.85
PNPLA6 0.87 0.84
ACP2 0.86 0.87
ATP6V0C 0.86 0.87
AP2A1 0.86 0.86
CAPNS1 0.86 0.83
GPI 0.86 0.84
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.62 -0.44
AF347015.18 -0.56 -0.44
AF347015.8 -0.55 -0.40
MT-CO2 -0.54 -0.39
AF347015.2 -0.54 -0.36
MT-ATP8 -0.53 -0.42
AF347015.31 -0.53 -0.38
MT-CYB -0.52 -0.37
NOSTRIN -0.52 -0.38
AF347015.26 -0.51 -0.35

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0001758 retinal dehydrogenase activity IEA -
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity IEA -
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity TAS 8663198
去：0009055 电子载体活动 TAS 8797830
GO:0016491 oxidoreductase activity IEA -
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0030182 neuron differentiation IEA neuron (GO term level: 8) -
GO:0030902 hindbrain development IEA Brain (GO term level: 8) -
GO:0030900 forebrain development IEA Brain (GO term level: 8) -
GO:0003007 心形形态发生 IEA -
GO:0009954 proximal/distal pattern formation IEA -
GO:0009952 anterior/posterior pattern formation IEA -
GO:0008284 positive regulation of cell proliferation IEA -
去：0009855 双边对称性的测定 IEA -
GO:0008152 metabolic process IEA -
GO:0014032 神经rest细胞发育 IEA -
GO:0016331 morphogenesis of embryonic epithelium IEA -
GO:0031016 pancreas development IEA -
GO:0042573 retinoic acid metabolic process IEA -
GO:0048384 retinoic acid receptor signaling pathway IEA -
GO:0043010 camera-type eye development IEA -
GO:0035115 embryonic forelimb morphogenesis IEA -
GO:0055114 oxidation reduction IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005737 细胞质 IEA -

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG RETINOL METABOLISM 64 37 该途径中的所有SZGR 2.0基因
GRABARCZYK BCL11B TARGETS DN 57 35 该途径中的所有SZGR 2.0基因
BASAKI YBX1 TARGETS DN 384 230 该途径中的所有SZGR 2.0基因
vecchi胃癌早期DN 367 220 该途径中的所有SZGR 2.0基因
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185 126 该途径中的所有SZGR 2.0基因
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204 140 该途径中的所有SZGR 2.0基因
runx1 runx1t1融合红细胞的TONKS目标 157 104 该途径中的所有SZGR 2.0基因
单核细胞中维持的runx1 runx1t1融合的tonks目标 21 15 该途径中的所有SZGR 2.0基因
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP 44 30 该途径中的所有SZGR 2.0基因
DELYS THYROID CANCER DN 232 154 该途径中的所有SZGR 2.0基因
MARKEY RB1 ACUTE LOF DN 228 137 该途径中的所有SZGR 2.0基因
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 该途径中的所有SZGR 2.0基因
MAHADEVAN IMATINIB RESISTANCE DN 20 11 该途径中的所有SZGR 2.0基因
WONG ENDMETRIUM CANCER DN 82 53 该途径中的所有SZGR 2.0基因
PAX3 FOXO1融合的Ebauer目标 207 128 该途径中的所有SZGR 2.0基因
YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 DN 87 48 该途径中的所有SZGR 2.0基因
PUJANA BRCA2 PCC NETWORK 423 265 该途径中的所有SZGR 2.0基因
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 该途径中的所有SZGR 2.0基因
BYSTRYKH造血干细胞QTL Trans 882 572 该途径中的所有SZGR 2.0基因
YAO HOXA10 TARGETS VIA PROGESTERONE DN 19 12 该途径中的所有SZGR 2.0基因
URS ADIPOCYTE DIFFERENTIATION UP 74 51 该途径中的所有SZGR 2.0基因
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE UP 1691年 1088 该途径中的所有SZGR 2.0基因
NIELSEN GIST AND SYNOVIAL SARCOMA UP 20 15 该途径中的所有SZGR 2.0基因
BOQUEST STEM CELL DN 216 143 该途径中的所有SZGR 2.0基因
ALONSO METASTASIS UP 198 128 该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 该途径中的所有SZGR 2.0基因
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 该途径中的所有SZGR 2.0基因
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11 103 68 该途径中的所有SZGR 2.0基因
LEE BMP2 TARGETS UP 745 475 该途径中的所有SZGR 2.0基因
SCHMIDT POR TARGETS IN LIMB BUD DN 8 7 该途径中的所有SZGR 2.0基因
Plasari TGFB1靶向10小时 199 143 该途径中的所有SZGR 2.0基因
RAO BOUND BY SALL4 ISOFORM A 182 108 该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

mirna家族 Target position miRNA ID miRNA seq
UTR start UTR end Match method
mir-137 1744 1750 1A hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-203.1 502 508 1A HSA-MIR-203 UGAAAUGUUUAGGACCACUAG
miR-23 1688年 1695 1A,m8 hsa-miR-23abrain aucacauugccagggauucc
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-323 1688年 1694 1A HSA-MIR-323brain gcacauuacggucgaccucu
miR-329 737 743 m8 HSA-MIR-329brain AACACACCUGGUUAACCUCUUU