Gene Page:MCM3AP
Summary?
| GeneID | 8888 |
| Symbol | MCM3AP |
| Synonyms | GANP|MAP80|SAC3 |
| Description | minichromosome maintenance complex component 3 associated protein |
| Reference | MIM:603294|HGNC:HGNC:6946|Ensembl:ENSG00000160294|HPRD:04483|Vega:OTTHUMG00000090630 |
| Gene type | protein-coding |
| Map location | 21q22.3 |
| Pascal p-value | 0.025 |
| Sherlock p-value | 0.125 |
| eGene | Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17183318 | 21 | 47661163 | MCM3AP | ENSG00000160294.6 | 2.501E-6 | 0 | 45048 | gtex_brain_putamen_basal |
| rs2839179 | 21 | 47681041 | MCM3AP | ENSG00000160294.6 | 8.207E-7 | 0 | 25170 | gtex_brain_putamen_basal |
| rs2839183 | 21 | 47687144 | MCM3AP | ENSG00000160294.6 | 2.427E-6 | 0 | 19067 | gtex_brain_putamen_basal |
| rs17182788 | 21 | 47687982 | MCM3AP | ENSG00000160294.6 | 8.245E-7 | 0 | 18229 | gtex_brain_putamen_basal |
| rs2839217 | 21 | 47766650 | MCM3AP | ENSG00000160294.6 | 1.419E-6 | 0 | -60439 | gtex_brain_putamen_basal |
| rs2839218 | 21 | 47771056 | MCM3AP | ENSG00000160294.6 | 1.391E-6 | 0 | -64845 | gtex_brain_putamen_basal |
| rs67986301 | 21 | 47786088 | MCM3AP | ENSG00000160294.6 | 2.156E-6 | 0 | -79877 | gtex_brain_putamen_basal |
| rs2839229 | 21 | 47789528 | MCM3AP | ENSG00000160294.6 | 1.411E-6 | 0 | -83317 | gtex_brain_putamen_basal |
| rs200603931 | 21 | 47791131 | MCM3AP | ENSG00000160294.6 | 2.014E-6 | 0 | -84920 | gtex_brain_putamen_basal |
| rs34095506 | 21 | 47791132 | MCM3AP | ENSG00000160294.6 | 2.874E-6 | 0 | -84921 | gtex_brain_putamen_basal |
| rs397866655 | 21 | 47795522 | MCM3AP | ENSG00000160294.6 | 1.422E-6 | 0 | -89311 | gtex_brain_putamen_basal |
| rs8127251 | 21 | 47797626 | MCM3AP | ENSG00000160294.6 | 1.709E-6 | 0 | -91415 | gtex_brain_putamen_basal |
| rs2877143 | 21 | 47799514 | MCM3AP | ENSG00000160294.6 | 1.419E-6 | 0 | -93303 | gtex_brain_putamen_basal |
| rs11089063 | 21 | 47800907 | MCM3AP | ENSG00000160294.6 | 1.426E-6 | 0 | -94696 | gtex_brain_putamen_basal |
| rs11089064 | 21 | 47800985 | MCM3AP | ENSG00000160294.6 | 1.411E-6 | 0 | -94774 | gtex_brain_putamen_basal |
| rs3737438 | 21 | 47811272 | MCM3AP | ENSG00000160294.6 | 1.421E-6 | 0 | -105061 | gtex_brain_putamen_basal |
| rs11702433 | 21 | 47813015 | MCM3AP | ENSG00000160294.6 | 1.419E-6 | 0 | -106804 | gtex_brain_putamen_basal |
| rs9975854 | 21 | 47813646 | MCM3AP | ENSG00000160294.6 | 2.225E-6 | 0 | -107435 | gtex_brain_putamen_basal |
| rs2073382 | 21 | 47818298 | MCM3AP | ENSG00000160294.6 | 1.419E-6 | 0 | -112087 | gtex_brain_putamen_basal |
| rs2032109 | 21 | 47820654 | MCM3AP | ENSG00000160294.6 | 2.174E-6 | 0 | -114443 | gtex_brain_putamen_basal |
| rs2839241 | 21 | 47821726 | MCM3AP | ENSG00000160294.6 | 2.174E-6 | 0 | -115515 | gtex_brain_putamen_basal |
| rs2839242 | 21 | 47825890 | MCM3AP | ENSG00000160294.6 | 1.413E-6 | 0 | -119679 | gtex_brain_putamen_basal |
| rs7276637 | 21 | 47829399 | MCM3AP | ENSG00000160294.6 | 1.581E-6 | 0 | -123188 | gtex_brain_putamen_basal |
| rs11702718 | 21 | 47839490 | MCM3AP | ENSG00000160294.6 | 2.174E-6 | 0 | -133279 | gtex_brain_putamen_basal |
| rs2839250 | 21 | 47841554 | MCM3AP | ENSG00000160294.6 | 2.174E-6 | 0 | -135343 | gtex_brain_putamen_basal |
| rs200577411 | 21 | 47845990 | MCM3AP | ENSG00000160294.6 | 2.665E-6 | 0 | -139779 | gtex_brain_putamen_basal |
| rs2300561 | 21 | 47852581 | MCM3AP | ENSG00000160294.6 | 2.178E-6 | 0 | -146370 | gtex_brain_putamen_basal |
| rs60135034 | 21 | 47853029 | MCM3AP | ENSG00000160294.6 | 2.004E-6 | 0 | -146818 | gtex_brain_putamen_basal |
| rs2839258 | 21 | 47854229 | MCM3AP | ENSG00000160294.6 | 2.199E-6 | 0 | -148018 | gtex_brain_putamen_basal |
| rs60407402 | 21 | 47855509 | MCM3AP | ENSG00000160294.6 | 1.427E-6 | 0 | -149298年 | gtex_brain_putamen_basal |
| rs2236616 | 21 | 47856106 | MCM3AP | ENSG00000160294.6 | 8.294E-7 | 0 | -149895 | gtex_brain_putamen_basal |
| rs4818847 | 21 | 48004563 | MCM3AP | ENSG00000160294.6 | 9.346E-8 | 0 | -298352 | gtex_brain_putamen_basal |
| rs7278437 | 21 | 48011220 | MCM3AP | ENSG00000160294.6 | 1.751E-7 | 0 | -305009 | gtex_brain_putamen_basal |
| rs4464358 | 21 | 48030617 | MCM3AP | ENSG00000160294.6 | 1.502E-6 | 0 | -324406 | gtex_brain_putamen_basal |
| rs3810593 | 21 | 48055357 | MCM3AP | ENSG00000160294.6 | 8.972E-7 | 0 | -349146 | gtex_brain_putamen_basal |
| rs2839368 | 21 | 48055377 | MCM3AP | ENSG00000160294.6 | 8.927E-7 | 0 | -349166 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CALY | 0.67 | 0.69 |
| PHLDA3 | 0.67 | 0.70 |
| GAL3ST1 | 0.66 | 0.62 |
| SPATA20 | 0.65 | 0.63 |
| C19orf46 | 0.65 | 0.70 |
| ANKRD9 | 0.64 | 0.74 |
| KLHDC9 | 0.64 | 0.73 |
| LDHD | 0.64 | 0.73 |
| KCNK4 | 0.63 | 0.70 |
| LGI4 | 0.63 | 0.69 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SEMA3A | -0.54 | -0.46 |
| SSBP2 | -0.52 | -0.43 |
| IGF2BP2 | -0.52 | -0.53 |
| CBLB | -0.52 | -0.42 |
| ZNF238 | -0.52 | -0.43 |
| DAB1 | -0.52 | -0.47 |
| FOXG1B | -0.51 | -0.44 |
| NEUROD6 | -0.51 | -0.49 |
| EML1 | -0.51 | -0.40 |
| PBX1 | -0.51 | -0.43 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | All SZGR 2.0 genes in this pathway |
| HOEBEKE LYMPHOID STEM CELL UP | 95 | 64 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS DN | 536 | 332 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE DN | 485 | 334 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
| FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP | 167 | 92 | All SZGR 2.0 genes in this pathway |
| KAUFFMANN DNA REPLICATION GENES | 147 | 87 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 21Q22 AMPLICON | 16 | 11 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS | 185 | 114 | All SZGR 2.0 genes in this pathway |
| LEE LIVER CANCER ACOX1 DN | 65 | 39 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| HESS TARGETS OF HOXA9 AND MEIS1 UP | 65 | 44 | All SZGR 2.0 genes in this pathway |
| MOREAUX MULTIPLE MYELOMA BY TACI DN | 172 | 107 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| CERIBELLI PROMOTERS INACTIVE AND BOUND BY NFY | 44 | 20 | All SZGR 2.0 genes in this pathway |