Gene Page:EIF2B4
Summary?
| GeneID | 8890 |
| Symbol | EIF2B4 |
| Synonyms | EIF-2B|EIF2B|EIF2Bdelta |
| Description | eukaryotic translation initiation factor 2B subunit delta |
| Reference | MIM:606687|HGNC:HGNC:3260|Ensembl:ENSG00000115211|HPRD:09459|Vega:OTTHUMG00000151927 |
| Gene type | protein-coding |
| Map location | 2p23.3 |
| Pascal p-value | 0.001 |
| Sherlock p-value | 0.606 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| 去_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 2 |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1568778 | chr7 | 109250931 | EIF2B4 | 8890 | 0.09 | trans | ||
| rs711457 | chr7 | 109264996 | EIF2B4 | 8890 | 0.11 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AGTPBP1 | 0.90 | 0.93 |
| MDGA2 | 0.89 | 0.91 |
| CLASP2 | 0.89 | 0.93 |
| WDR44 | 0.89 | 0.92 |
| RAB9B | 0.88 | 0.91 |
| PAPD5 | 0.88 | 0.92 |
| PCYOX1 | 0.88 | 0.91 |
| RTN4 | 0.87 | 0.92 |
| GNPTAB | 0.87 | 0.91 |
| MGEA5 | 0.87 | 0.91 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.70 | -0.80 |
| MT-CO2 | -0.69 | -0.81 |
| FXYD1 | -0.69 | -0.79 |
| TSC22D4 | -0.67 | -0.75 |
| SLC25A18 | -0.67 | -0.76 |
| ROM1 | -0.67 | -0.77 |
| AF347015.33 | -0.67 | -0.76 |
| MT-CYB | -0.67 | -0.77 |
| HIGD1B | -0.66 | -0.79 |
| HSD17B14 | -0.66 | -0.75 |
Section III. Gene Ontology annotation
| Molecular function | 去term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| 去:0005085 | guanyl-nucleotide交换因素活动 | IDA | 11323413 | |
| 去:0005085 | guanyl-nucleotide交换因素活动 | IMP | 15054402 | |
| 去:0003743 | translation initiation factor activity | IDA | 16289705 | |
| 去:0003743 | translation initiation factor activity | IEA | - | |
| 去:0005515 | protein binding | 新闻学会 | 15060152 | |
| Biological process | 去term | Evidence | Neuro keywords | PubMed ID |
| 去:0014003 | oligodendrocyte development | IMP | axon, oligodendrocyte, Glial (GO term level: 10) | 15217090 |
| 去:0042552 | myelination | IMP | neuron, axon, Brain, oligodendrocyte (GO term level: 13) | 14566705 |
| 去:0001541 | ovarian follicle development | IMP | 15507143 | |
| 去:0006413 | translational initiation | IDA | 16289705 | |
| 去:0006417 | regulation of translation | NAS | 12556349 | |
| 去:0009408 | response to heat | ISS | - | |
| 去:0009408 | response to heat | TAS | 12499492 | |
| 去:0009749 | response to glucose stimulus | ISS | - | |
| 去:0043434 | response to peptide hormone stimulus | ISS | - | |
| 去:0044237 | cellular metabolic process | IEA | - | |
| 去:0051716 | cellular response to stimulus | IDA | 8626696 | |
| Cellular component | 去term | Evidence | Neuro keywords | PubMed ID |
| 去:0005851 | eukaryotic translation initiation factor 2B complex | IDA | 11323413|15060152 | |
| 去:0005737 | cytoplasm | IDA | 11323413 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BIOCARTA VEGF PATHWAY | 29 | 18 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSLATION | 222 | 75 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF PROTEINS | 518 | 242 | All SZGR 2.0 genes in this pathway |
| GARY CD5 TARGETS DN | 431 | 263 | All SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS DN | 352 | 225 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS | 185 | 114 | All SZGR 2.0 genes in this pathway |
| PENG LEUCINE DEPRIVATION DN | 187 | 122 | All SZGR 2.0 genes in this pathway |
| PENG GLUCOSE DEPRIVATION DN | 169 | 112 | All SZGR 2.0 genes in this pathway |
| PENG RAPAMYCIN RESPONSE DN | 245 | 154 | All SZGR 2.0 genes in this pathway |
| PENG GLUTAMINE DEPRIVATION DN | 337 | 230 | All SZGR 2.0 genes in this pathway |
| KIM GASTRIC CANCER CHEMOSENSITIVITY | 103 | 64 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS UP | 566 | 371 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH 11Q23 REARRANGED | 351 | 238 | All SZGR 2.0 genes in this pathway |
| CAIRO HEPATOBLASTOMA CLASSES UP | 605 | 377 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP | 756 | 494 | All SZGR 2.0 genes in this pathway |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | All SZGR 2.0 genes in this pathway |
| HOLLEMAN DAUNORUBICIN B ALL UP | 10 | 9 | All SZGR 2.0 genes in this pathway |
| HOLLEMAN DAUNORUBICIN ALL UP | 7 | 5 | All SZGR 2.0 genes in this pathway |