Gene Page:EIF2S2

Summary?
GeneID 8894
Symbol EIF2S2
Synonyms EIF2|EIF2B|EIF2beta|PPP1R67|eIF-2-beta
Description eukaryotic translation initiation factor 2 subunit beta
Reference MIM:603908|HGNC:HGNC:3266|Ensembl:ENSG00000125977|HPRD:04882|Vega:OTTHUMG00000032287
Gene type protein-coding
Map location 20q11.2
Pascal p-value 0.003
Sherlock p-value 0.717
Support Ascano FMRP目标

Gene in Data Sources
基因集名称 Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0143

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KLHL17 0.95 0.89
AC145098.2 0.95 0.91
GIGYF1 0.93 0.92
CCDC142 0.93 0.92
QRICH2 0.93 0.92
TRPV1 0.92 0.90
ANO8 0.92 0.93
KIAA0913 0.92 0.93
ADAMTS10 0.92 0.92
MICAL1 0.92 0.90
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.65 -0.78
C5orf53 -0.65 -0.71
AF347015.27 -0.63 -0.75
ACOT13 -0.63 -0.69
B2M -0.63 -0.71
MT-CO2 -0.61 -0.75
MT-CYB -0.60 -0.73
S100B -0.60 -0.69
AF347015.33 -0.60 -0.71
COPZ2 -0.59 -0.67

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003723 RNA binding TAS 3044606
GO:0003743 translation initiation factor activity IDA 16289705
GO:0003743 translation initiation factor activity IEA -
GO:0005515 protein binding 新闻学会 16288713
GO:0008270 zinc ion binding IEA -
GO:0046872 metal ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006413 translational initiation IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005829 cytosol EXP 1104615|12588972
GO:0005850 eukaryotic translation initiation factor 2 complex TAS 3044606

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
APLP1 APLP amyloid beta (A4) precursor-like protein 1 Two-hybrid BioGRID 16169070
CCDC90B MDS011 | MDS025 | MGC104239 coiled-coil domain containing 90B Two-hybrid BioGRID 16169070
CRMP1 DPYSL1 | DRP-1 | DRP1 collapsin response mediator protein 1 Two-hybrid BioGRID 16169070
CSNK2A1 CK2A1 | CKII casein kinase 2, alpha 1 polypeptide EIF2beta interacts with CK2alpha. BIND 12901717
CSNK2B CK2B | CK2N | CSK2B | G5A | MGC138222 | MGC138224 casein kinase 2, beta polypeptide EIF2beta interacts with CK2beta. BIND 12901717
EIF2B1 EIF-2B | EIF-2Balpha | EIF2B | EIF2BA | MGC117409 | MGC125868 | MGC125869 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa - HPRD 9446619
EIF2B4 DKFZp586J0119 | EIF-2B | EIF2B | EIF2Bdelta eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa - HPRD 9446619
EIF2B5 CACH | CLE | EIF-2B | EIF2Bepsilon | LVWM eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa - HPRD 9446619
EIF5 EIF-5A eukaryotic translation initiation factor 5 - HPRD,BioGRID 9395514|10805737
|11092890
KIAA1377 - KIAA1377 Two-hybrid BioGRID 16169070
NCK1 MGC12668 | NCK | NCKalpha NCK adaptor protein 1 - HPRD 11959995
PLEKHM1 AP162 | B2 | KIAA0356 | OPTB6 pleckstrin homology domain containing, family M (with RUN domain) member 1 Two-hybrid BioGRID 16169070
PRKDC DNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350 protein kinase, DNA-activated, catalytic polypeptide - HPRD,BioGRID 9442054
TLE1 ESG | ESG1 | GRG1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) Two-hybrid BioGRID 16169070
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 Two-hybrid BioGRID 16169070
UNC119 HRG4 unc-119 homolog (C. elegans) Two-hybrid BioGRID 16169070
ZBTB16 PLZF | ZNF145 zinc finger and BTB domain containing 16 Two-hybrid BioGRID 16169070


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA RNA PATHWAY 10 9 All SZGR 2.0 genes in this pathway
BIOCARTA EIF PATHWAY 16 9 All SZGR 2.0 genes in this pathway
BIOCARTA EIF2 PATHWAY 11 8 All SZGR 2.0 genes in this pathway
BIOCARTA IGF1MTOR PATHWAY 20 14 All SZGR 2.0 genes in this pathway
BIOCARTA VEGF PATHWAY 29 18 All SZGR 2.0 genes in this pathway
REACTOME TRANSLATION 222 75 All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX 74 24 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 84 30 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518 242 All SZGR 2.0 genes in this pathway
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION 176 51 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
BARIS THYROID CANCER UP 23 9 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217 143 All SZGR 2.0 genes in this pathway
KIM MYC AMPLIFICATION TARGETS UP 201 127 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
TONG INTERACT WITH PTTG1 57 32 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED MODERATELY VS POORLY UP 121 71 All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP 77 60 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176 115 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS UP 126 84 All SZGR 2.0 genes in this pathway
RHODES UNDIFFERENTIATED CANCER 69 44 All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS PRENATAL 42 33 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311 205 All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 96 71 All SZGR 2.0 genes in this pathway
POS RESPONSE TO HISTAMINE DN 11 9 All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA 51 35 All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294 199 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245 159 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE 101 76 All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED B LYMPHOCYTE 81 66 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS UP 74 45 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335 193 All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS UP 127 78 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family 助教rget position miRNA ID miRNA seq
UTR开始 UTR end Match method
miR-128 1179 1186 1A,m8 hsa-miR-128a UCACAGUGAACCGGUCUCUUUU
hsa-miR-128b UCACAGUGAACCGGUCUCUUUC
miR-186 290 296 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-27 1180 1186 m8 hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-29 645 651 1A hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
miR-33 257 263 1A hsa-miR-33 GUGCAUUGUAGUUGCAUUG
hsa-miR-33b GUGCAUUGCUGUUGCAUUGCA
miR-335 450 456 1A hsa-miR-335brain UCAAGAGCAAUAACGAAAAAUGU
miR-362 1398 1404 m8 hsa-miR-362 AAUCCUUGGAACCUAGGUGUGAGU
miR-369-3p 277 283 1A hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 277 284 1A,m8 hsa - mir - 374 UUAUAAUACAACCUGAUAAGUG