Gene Page:AP1M1
Summary?
| GeneID | 8907 |
| Symbol | AP1M1 |
| Synonyms | AP47|CLAPM2|CLTNM|MU-1A |
| Description | adaptor related protein complex 1 mu 1 subunit |
| Reference | 米IM:603535|HGNC:HGNC:13667|Ensembl:ENSG00000072958|HPRD:04639|Vega:OTTHUMG00000182323 |
| Gene type | protein-coding |
| 米ap location | 19p13.12 |
| Pascal p-value | 0.045 |
| Sherlock p-value | 0.537 |
| eGene | Cerebellar Hemisphere Cerebellum Nucleus accumbens basal ganglia 米yers' cis & trans 元 |
| Support | ENDOCYTOSIS |
Gene in Data Sources
| Gene set name | 米ethod of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7554118 | chr1 | 34347105 | AP1M1 | 8907 | 0.14 | trans | ||
| rs9851591 | chr3 | 40042036 | AP1M1 | 8907 | 0.15 | trans | ||
| rs6791790 | chr3 | 40050274 | AP1M1 | 8907 | 0.15 | trans | ||
| rs4302323 | chr3 | 40052101 | AP1M1 | 8907 | 0.15 | trans | ||
| rs17093091 | chr14 | 23954891 | AP1M1 | 8907 | 0.18 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TNRC6A | 0.61 | 0.61 |
| NBPF12 | 0.61 | 0.55 |
| 米ACF1 | 0.60 | 0.60 |
| PROM2 | 0.59 | 0.55 |
| 米LL3 | 0.59 | 0.59 |
| CNKSR1 | 0.59 | 0.53 |
| 米LL | 0.59 | 0.56 |
| POLE | 0.59 | 0.57 |
| CHD2 | 0.59 | 0.60 |
| UBR4 | 0.59 | 0.53 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| IFI27 | -0.39 | -0.45 |
| 米GST2 | -0.38 | -0.44 |
| B2M | -0.38 | -0.43 |
| 米YL3 | -0.38 | -0.45 |
| 米T-CO2 | -0.37 | -0.44 |
| AF347015.31 | -0.37 | -0.44 |
| HIGD1B | -0.37 | -0.45 |
| ACOT13 | -0.37 | -0.39 |
| S100B | -0.37 | -0.43 |
| VAMP5 | -0.36 | -0.46 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AP1G1 | ADTG | CLAPG1 | MGC18255 | adaptor-related protein complex 1, gamma 1 subunit | Affinity Capture-Western | BioGRID | 10535737 |
| AP1M2 | AP1-mu2 | HSMU1B | MU-1B | MU1B | mu2 | adaptor-related protein complex 1, mu 2 subunit | - | HPRD | 10535737|11157985 |
| AP2B1 | ADTB2 | AP105B | AP2-BETA | CLAPB1 | DKFZp781K0743 | adaptor-related protein complex 2, beta 1 subunit | Two-hybrid | BioGRID | 16189514 |
| CTLA4 | CD152 | CELIAC3 | CTLA-4 | GSE | IDDM12 | cytotoxic T-lymphocyte-associated protein 4 | - | HPRD,BioGRID | 9812899|11583591 |
| DCX | DBCN | DC | LISX | SCLH | XLIS | doublecortin | - | HPRD | 11591131 |
| DVL2 | - | dishevelled, dsh homolog 2 (Drosophila) | Two-hybrid | BioGRID | 16189514 |
| EHD2 | FLJ96617 | PAST2 | EH-domain containing 2 | - | HPRD | 15182197 |
| FXR2 | FMR1L2 | fragile X mental retardation, autosomal homolog 2 | Two-hybrid | BioGRID | 16189514 |
| HNRNPC | C1 | C2 | HNRNP | HNRPC | MGC104306 | MGC105117 | MGC117353 | MGC131677 | SNRPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | Two-hybrid | BioGRID | 16189514 |
| KIF13A | FLJ27232 | bA500C11.2 | kinesin family member 13A | - | HPRD,BioGRID | 11106728 |
| LAMP1 | CD107a | LAMPA | LGP120 | lysosomal-associated membrane protein 1 | - | HPRD,BioGRID | 7569928 |
| LDOC1 | BCUR1 | Mar7 | Mart7 | leucine zipper, down-regulated in cancer 1 | Two-hybrid | BioGRID | 16189514 |
| 米TF1 | 米GC23036 | MTF-1 | ZRF | metal-regulatory transcription factor 1 | Two-hybrid | BioGRID | 16189514 |
| RUNDC3A | RAP2IP | RPIP8 | RUN domain containing 3A | Two-hybrid | BioGRID | 16189514 |
| SELP | CD62 | CD62P | FLJ45155 | GMP140 | GRMP | LECAM3 | PADGEM | PSEL | selectin P (granule membrane protein 140kDa, antigen CD62) | Co-crystal Structure | BioGRID | 11247301 |
| TGOLN2 | 米GC14722 | TGN38 | TGN46 | TGN48 | TGN51 | TTGN2 | trans-golgi network protein 2 | - | HPRD,BioGRID | 7569928 |
| TIFA | 米GC20791 | T2BP | T6BP | TIFAA | TRAF-interacting protein with forkhead-associated domain | Two-hybrid | BioGRID | 16189514 |
| VAMP4 | VAMP24 | vesicle-associated membrane protein 4 | - | HPRD,BioGRID | 11598115|14608369 |
| ZBTB8 | BOZF1 | FLJ90065 | MGC17919 | zinc finger and BTB domain containing 8 | Two-hybrid | BioGRID | 16189514 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG LYSOSOME | 121 | 83 | All SZGR 2.0 genes in this pathway |
| PID ECADHERIN NASCENT AJ PATHWAY | 39 | 33 | All SZGR 2.0 genes in this pathway |
| REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | 10 | 5 | All SZGR 2.0 genes in this pathway |
| REACTOME MEMBRANE TRAFFICKING | 129 | 74 | All SZGR 2.0 genes in this pathway |
| REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS | 21 | 12 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | 60 | 31 | All SZGR 2.0 genes in this pathway |
| REACTOME MHC CLASS II ANTIGEN PRESENTATION | 91 | 61 | All SZGR 2.0 genes in this pathway |
| REACTOME LYSOSOME VESICLE BIOGENESIS | 23 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | 53 | 27 | All SZGR 2.0 genes in this pathway |
| REACTOME HIV INFECTION | 207 | 122 | All SZGR 2.0 genes in this pathway |
| REACTOME HOST INTERACTIONS OF HIV FACTORS | 132 | 81 | All SZGR 2.0 genes in this pathway |
| REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | 28 | 19 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME适应性免疫系统 | 539 | 350 | All SZGR 2.0 genes in this pathway |
| RASHI RESPONSE TO IONIZING RADIATION 1 | 45 | 27 | All SZGR 2.0 genes in this pathway |
| GRADE COLON CANCER UP | 871 | 505 | All SZGR 2.0 genes in this pathway |
| CADWELL ATG16L1 TARGETS UP | 93 | 56 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| KASLER HDAC7 TARGETS 1 UP | 194 | 133 | All SZGR 2.0 genes in this pathway |