Gene Page:TIMELESS

Summary?
GeneID 8914
象征 TIMELESS
Synonyms TIM|TIM1|hTIM
Description timeless circadian clock
Reference MIM:603887|HGNC:HGNC:11813|Ensembl:ENSG00000111602|HPRD:04864|Vega:OTTHUMG00000170600
Gene type protein-coding
Map location 12q13.3
Pascal p-value 0.002
Fetal beta 1.034
DMG 1 (# studies)
eGene Myers' cis & trans
Support Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details

节n I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
ch.12.1183517F 12 56819834 TIMELESS 1.97E-5 -0.646 0.016 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs4757560 chr11 17690161 TIMELESS 8914 0.07 trans

节n II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PON2 0.55 0.53
C10orf54 0.54 0.59
ACOX2 0.53 0.57
B2M 0.53 0.57
SRGN 0.52 0.61
GIMAP2 0.52 0.52
TMBIM1 0.52 0.60
NMI 0.52 0.50
CXCL16 0.52 0.56
BBOX1 0.52 0.54
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RTF1 -0.46 -0.49
DPF1 -0.46 -0.51
BOP1 -0.46 -0.50
CHD3 -0.46 -0.51
GTF2F1 -0.46 -0.49
SAFB -0.46 -0.48
AC011498.3 -0.45 -0.49
ZNF643 -0.45 -0.49
NOVA2 -0.45 -0.49
NCL -0.45 -0.49

节n III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005515 protein binding ISS -
GO:0046982 protein heterodimerization activity ISS -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0002009 上皮细胞的形态发生 ISS -
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0007049 cell cycle IEA -
GO:0007067 mitosis IEA -
GO:0009582 detection of abiotic stimulus TAS 9856466
GO:0007623 circadian rhythm ISS -
GO:0006974 response to DNA damage stimulus IEA -
GO:0007275 multicellular organismal development IEA -
GO:0016481 negative regulation of transcription IDA 9856465
GO:0033261 regulation of S phase IMP 17102137
GO:0042127 regulation of cell proliferation IMP 17102137
GO:0051301 cell division IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0000790 nuclear chromatin IDA 17102137
GO:0005634 nucleus IC 9856465

节n V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID ATR PATHWAY 39 25 All SZGR 2.0 genes in this pathway
PID CIRCADIAN PATHWAY 16 15 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201 125 All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP 151 84 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
DITTMER PTHLH TARGETS DN 73 51 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
NADERI BREAST CANCER PROGNOSIS UP 50 26 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
BERENJENO变换ED BY RHOA UP 536 340 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING UP 108 69 All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK 168 103 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK 117 72 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163 115 All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH CHROMOSOME 12 TRISOMY 24 12 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428 266 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC 210 123 All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202 132 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO SERM OR FULVESTRANT DN 50 29 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN 185 116 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277 166 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS DN 89 50 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368 247 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN 251 151 All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 All SZGR 2.0 genes in this pathway
开罗肝母细胞癌类了 605 377 All SZGR 2.0 genes in this pathway
WINNEPENNINCKX MELANOMA METASTASIS UP 162 86 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS GROWING 243 155 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324 193 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS DN 148 88 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 6HR 85 49 All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR 128 73 All SZGR 2.0 genes in this pathway