Gene Page:HERC1

Summary?
GeneID 8925
Symbol HERC1
Synonyms p532|p619
Description HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Reference MIM:605109|HGNC:HGNC:4867|Ensembl:ENSG00000103657|HPRD:06894|Vega:OTTHUMG00000172433
Gene type protein-coding
Map location 15q22
Pascal p-value 0.464
Sherlock p-value 0.362
Fetal beta -0.111
DMG 1 (# studies)
Support CompositeSet
Darnell FMRP targets
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg01888129 15 64126210 HERC1 3.428E-4 -0.18 0.041 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RPL19P12 0.96 0.93
RPL32 0.96 0.94
RPS19P3 0.95 0.92
RPLP2 0.94 0.92
RPS23 0.94 0.92
RPL18 0.94 0.91
RPS18 0.94 0.93
RPS8 0.93 0.94
RPS11P5 0.93 0.92
RPL10A 0.93 0.94
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ATP10A -0.63 -0.72
APOL1 -0.62 -0.73
ZBTB7B -0.62 -0.75
BCL2L2 -0.62 -0.68
HLA-F -0.62 -0.68
SYNM -0.62 -0.69
MYH14 -0.61 -0.77
EPB41L2 -0.61 -0.69
FBXO2 -0.61 -0.65
AF347015.27 -0.61 -0.70

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 138 98 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN 240 171 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP 140 85 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN 50 32 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D DN 64 35 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER POOR SURVIVAL UP 31 22 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
CHNG MULTIPLE MYELOMA HYPERPLOID UP 52 25 All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222 141 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway