Gene Page:WASF1
概括?
| 基因 | 8936 |
| 象征 | WASF1 |
| Synonyms | SCAR1|WAVE|WAVE1 |
| Description | WAS protein family member 1 |
| Reference | MIM: 605035|HGNC:HGNC:12732|Ensembl:ENSG00000112290|HPRD:05434|Vega：Otthumg0000000015357 |
| Gene type | protein-coding |
| Map location | 6q21 |
| Pascal p-value | 0.096 |
| Sherlock p-value | 0.804 |
| 度p-value | 度:Maycox_2009:CC_BA10_fold_change=-1.11:CC_BA10_disease_P=0.0291:HBB_BA9_fold_change=-1.15:HBB_BA9_disease_P=0.0091 |
| Fetal beta | 0.117 |
| eGene | Myers' cis & trans |
| Support | INTRACELLULAR SIGNAL TRANSDUCTION G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS COMPOSITESET Darnell FMRP targets Potential synaptic genes |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| 度:Maycox_2009 | Microarray to determine the expression of over 30000 mRNA transcripts in post-mortem tissue | We included 51 genes whose expression changes are common between two schizophrenia cohorts. |
第一节遗传学和表观遗传学注释
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| snp_a-1983537 | 0 | WASF1 | 8936 | 0.13 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26页ostconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SYK | 0.73 | 0.65 |
| FCGR3A | 0.73 | 0.66 |
| VSIG4 | 0.73 | 0.72 |
| NCKAP1L | 0.73 | 0.71 |
| CD68 | 0.72 | 0.73 |
| FCGR1A | 0.72 | 0.57 |
| HCK | 0.72 | 0.65 |
| SIGLEC10 | 0.71 | 0.65 |
| ITGB2 | 0.70 | 0.68 |
| FPR1 | 0.70 | 0.56 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.27 | -0.34 |
| AF347015.26 | -0.26 | -0.34 |
| AF347015.18 | -0.26 | -0.36 |
| AF347015.8 | -0.26 | -0.33 |
| AF347015.2 | -0.25 | -0.35 |
| AF347015.33 | -0.25 | -0.31 |
| AF347015.27 | -0.25 | -0.32 |
| AC098691.2 | -0.24 | -0.32 |
| MT-CYB | -0.24 | -0.31 |
| AF347015.31 | -0.23 | -0.31 |
第四节。蛋白质蛋白相互作用注释
| Interactors | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | WAVE-1 interacts with Abl. | BIND | 10970852 |
| ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | - | HPRD | 10970852 |
| ACTG1 | ACT | ACTG | DFNA20 | DFNA26 | actin, gamma 1 | WAVE-1 interacts with G-actin. This interaction was modeled on a demonstrated interaction between human WAVE-1 and rat G-actin. | BIND | 10970852 |
| ARHGEF2 | DKFZp547L106 | DKFZp547P1516 | GEF | GEF-H1 | GEFH1 | KIAA0651 | LFP40 | P40 | Rho/RAC鸟嘌呤核苷酸交换因子（GEF）2 | Affinity Capture-Western | BioGRID | 9843499 |
| BAIAP2 | BAP2 | IRSP53 | BAI1-associated protein 2 | Far Western Reconstituted Complex 两个杂交 |
BioGRID | 11130076 |
| C3orf10 | HSPC300 | MDS027 | hHBrk1 | chromosome 3 open reading frame 10 | - | HPRD | 12181570 |
| CDC42 | cdc42hs |G25K | cell division cycle 42 (GTP binding protein, 25kDa) | - | HPRD | 12181570 |
| DNMBP | KIAA1010 | TUBA | dynamin binding protein | - | HPRD,BioGRID | 14506234 |
| Fyn | MGC45350 | SLK | SYN | Fynoncogene related to SRC, FGR, YES | - | HPRD | 10532312 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD | 9307968 |
| PFN1 | - | profilin 1 | - | HPRD,BioGRID | 9843499 |
| PRKAR2A | MGC3606 | PKR2 | PRKAR2 | protein kinase, cAMP-dependent, regulatory, type II, alpha | WAVE-1 interacts with PKA. | BIND | 10970852 |
| PSTPIP1 | CD2BP1 | CD2BP1L | CD2BP1S | H-PIP | PAPAS | PSTPIP | proline-serine-threonine phosphatase interacting protein 1 | - | HPRD | 9804817 |
| RAC1 | MGC111543 | MIG5 | TC-25 | p21-Rac1 | 与RAS相关的C3肉毒纤维毒素底物1（RHO家族，小GTP结合蛋白Rac1） | - | HPRD | 9843499 |
| SRGAP3 | ARHGAP14 | KIAA0411 | MEGAP | SRGAP2 | WRP | SLIT-ROBO Rho GTPase activating protein 3 | - | HPRD,BioGRID | 12447388 |
| SRGAP3 | ARHGAP14 | KIAA0411 | MEGAP | SRGAP2 | WRP | SLIT-ROBO Rho GTPase activating protein 3 | WAVE1 interacts with WRP. This interaction was modeled on a demonstrated interaction between WAVE-1 from rat and an unspecified sources and WRP from rat, human and an unspecified sources. | BIND | 12447388 |
V.途径注释
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG ADHERENS JUNCTION | 75 | 53 | 该途径中的所有SZGR 2.0基因 |
| KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS | 97 | 71 | 该途径中的所有SZGR 2.0基因 |
| 肌动蛋白细胞骨架的KEGG调节 | 216 | 144 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA SALMONELLA PATHWAY | 13 | 10 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA RAC1 PATHWAY | 23 | 16 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA ACTINY PATHWAY | 20 | 14 | 该途径中的所有SZGR 2.0基因 |
| SIG趋化性 | 45 | 37 | 该途径中的所有SZGR 2.0基因 |
| Rho GTPases对肌动蛋白细胞骨架的SIG调节 | 35 | 25 | 该途径中的所有SZGR 2.0基因 |
| PID E2F途径 | 74 | 48 | 该途径中的所有SZGR 2.0基因 |
| PID RAC1 PATHWAY | 54 | 37 | 该途径中的所有SZGR 2.0基因 |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | 362 | 238 | 该途径中的所有SZGR 2.0基因 |
| MULLIGHAN MLL SIGNATURE 1 DN | 242 | 165 | 该途径中的所有SZGR 2.0基因 |
| MULLIGHAN MLL SIGNATURE 2 DN | 281 | 186 | 该途径中的所有SZGR 2.0基因 |
| LEE NEURAL CREST STEM CELL DN | 118 | 79 | 该途径中的所有SZGR 2.0基因 |
| HUMMEL BURKITTS LYMPHOMA UP | 43 | 27 | 该途径中的所有SZGR 2.0基因 |
| JAATINEN HEMATOPOIETIC STEM CELL UP | 316 | 190 | 该途径中的所有SZGR 2.0基因 |
| ENK UV RESPONSE KERATINOCYTE DN | 485 | 334 | 该途径中的所有SZGR 2.0基因 |
| DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | 该途径中的所有SZGR 2.0基因 |
| Schaeffer前列腺开发48小时DN | 428 | 306 | 该途径中的所有SZGR 2.0基因 |
| SMITH TERT TARGETS UP | 145 | 91 | 该途径中的所有SZGR 2.0基因 |
| ALCALAY AML BY NPM1 LOCALIZATION DN | 184 | 132 | 该途径中的所有SZGR 2.0基因 |
| NPM1突变DN的Verhaak AML | 246 | 180 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | 该途径中的所有SZGR 2.0基因 |
| Geiss对DSRNA DN的响应 | 16 | 8 | 该途径中的所有SZGR 2.0基因 |
| DOUGLAS BMI1 TARGETS UP | 566 | 371 | 该途径中的所有SZGR 2.0基因 |
| Creighton内分泌疗法抗性1 | 528 | 324 | 该途径中的所有SZGR 2.0基因 |
| 由Foxp3绑定的Marson未刺激 | 1229 | 713 | 该途径中的所有SZGR 2.0基因 |
| HELLER HDAC TARGETS UP | 317 | 208 | 该途径中的所有SZGR 2.0基因 |
| Heller HDAC靶向被甲基化的沉默 | 461 | 298 | 该途径中的所有SZGR 2.0基因 |
| MASSARWEH TAMOXIFEN RESISTANCE DN | 258 | 160 | 该途径中的所有SZGR 2.0基因 |
| BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING | 246 | 152 | 该途径中的所有SZGR 2.0基因 |
| Aguirre胰腺癌拷贝编号DN | 238 | 145 | 该途径中的所有SZGR 2.0基因 |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | 456 | 285 | 该途径中的所有SZGR 2.0基因 |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | 该途径中的所有SZGR 2.0基因 |
| CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP | 178 | 108 | 该途径中的所有SZGR 2.0基因 |
| CAIRO LIVER DEVELOPMENT UP | 166 | 105 | 该途径中的所有SZGR 2.0基因 |
| VERHAAK GLIOBLASTOMA PRONEURAL | 177 | 132 | 该途径中的所有SZGR 2.0基因 |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | 该途径中的所有SZGR 2.0基因 |