Gene Page:CCND2

Summary？
GeneID 894
Symbol CCND2
Synonyms Kiak0002 | mpph3
Description cyclin D2
Reference MIM：123833|HGNC：HGNC：1583|ENSEMBL：ENSG00000118971|HPRD:00451|Vega：Otthumg00000168123
基因类型 蛋白质编码
Map location 12p13
Pascal p-value 0.071
Sherlock p-value 0.05
胎儿β 0.734
DMG 2(# studies)

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp Genome-wide Association Study GWAS
DMG：JAFFE_2016 全基因组DNA甲基化分析 This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG：Wockner_2014 全基因组DNA甲基化分析 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 2
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症 点击显示详细信息

部分即遗传学和表观遗传学注释

@Differentially methylated gene

Probe 染色体 位置 Nearest gene p（dis） Beta (dis) fdr（dis） 学习
CG11135021 12 4382112 CCND2 5.262E-4 -0.46 0.048 DMG：Wockner_2014
cg10689512 12 4381019 CCND2 6.93E-8 -0.026 1.68E-5 DMG：JAFFE_2016


第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RBM15B 0.93 0.93
Znf71 0.93 0.94
EPHB2 0.93 0.93
NUP62 0.92 0.93
ZNF48 0.92 0.94
CCDC97 0.92 0.90
AKT1 0.92 0.90
DNMT1 0.92 0.93
PFA 0.92 0.93
CABLES2 0.92 0.95
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.74 -0.89
AF347015.27 -0.73 -0.88
MT-CO2 -0.72 -0.88
AF347015.33 -0.71 -0.85
mt-cyb -0.70 -0.86
AF347015.8 -0.70 -0.88
C5orf53 -0.69 -0.74
S100B -0.69 -0.81
FXYD1 -0.68 -0.83
HLA-F -0.68 -0.73

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
AKAP8 AKAP95 | DKFZp586B1222 A kinase (PRKA) anchor protein 8 - HPRD,BioGRID 14641107
Bcl6 BCL5 | BCL6A | LAZ3 | ZBTB27 | ZNF51 B细胞CLL/淋巴瘤6 Bcl6与CCND2启动子区域相互作用。 绑定 15531890
CDK4 CMM3 |MGC14458 |PSK-J3 cyclin-dependent kinase 4 CCND2与CDK4相互作用 绑定 11291051
CDK4 CMM3 |MGC14458 |PSK-J3 cyclin-dependent kinase 4 - HPRD,BioGRID 11358847
CDK5 PSSALRE cyclin-dependent kinase 5 - HPRD,BioGRID 9422379
CDK6 MGC59692 | PLSTIRE | STQTL11 cyclin-dependent kinase 6 - HPRD,BioGRID 11358847
CDKN1A CAP20 |CDKN1 |CIP1 |MDA-6 |p21 |SDI1 |WAF1 |P21CIP1 细胞周期蛋白依赖性激酶抑制剂1a（P21，CIP1） Two-hybrid Biogrid 16189514
CDKN1B CDKN4 |Kip1 |men1b |Men4 |P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) Two-hybrid Biogrid 16189514
CDKN2A ARF | CDK4I | CDKN2 | CMM2 | INK4 | INK4a | MLM | MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19 cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 重构的复合物 Biogrid 15065884
DMTF1 DMP1 |DMTF |FLJ41265 |HDMP1 Cyclin D结合MYB样转录因子1 - HPRD 8887674
NCOR1 KIAA1047 |MGC104216 |n-cor |trac1 |HCIT529I10 |hn-cor 核受体共抑制剂1 NcoR interacts with the CCND2 promoter region. 绑定 15531890
NCOR2 CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1 核受体共抑制剂2 SMRT与CCND2启动子区域相互作用。 绑定 15531890
NPDC1 CAB | CAB- | CAB-1 | CAB1 | DKFZp586J0523 神经增殖，分化和控制，1 - HPRD,BioGRID 11042687
RBX1 BA554C12.1 |MGC13357 |MGC1481 |RNF75 |ROC1 ring-box 1 亲和力捕获 - 韦斯特恩 Biogrid 11311237
SERTAD1 sei1 |Trip-BR1 SERTA domain containing 1 - HPRD,BioGRID 15065884
STAT5A MGF | STAT5 signal transducer and activator of transcription 5A Stat5a与Cyclin D2启动子相互作用。 绑定 15735688
TSC2 FLJ43106 | LAM | TSC4 tuberous sclerosis 2 亲和力捕获 - 韦斯特恩 Biogrid 16357142


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
kegg细胞周期 128 84 All SZGR 2.0 genes in this pathway
KEGG P53信号通路 69 45 All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY 151 112 All SZGR 2.0 genes in this pathway
kegg焦点粘附 201 138 All SZGR 2.0 genes in this pathway
kegg jak stat信号通路 155 105 All SZGR 2.0 genes in this pathway
生物卡塔尔细胞途径 23 15 All SZGR 2.0 genes in this pathway
wnt信令 89 71 All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY 79 62 All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY 80 60 All SZGR 2.0 genes in this pathway
PID IL2 STAT5 PATHWAY 30 23 All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY 65 46 All SZGR 2.0 genes in this pathway
反应组细胞周期 421 253 All SZGR 2.0 genes in this pathway
反应组细胞周期MITOTIC 325 185 All SZGR 2.0 genes in this pathway
Reactome G1相 38 23 All SZGR 2.0 genes in this pathway
Reactome有丝分裂G1 G1 S相 137 79 All SZGR 2.0 genes in this pathway
KORKOLA EMBRYONAL CARCINOMA UP 41 27 All SZGR 2.0 genes in this pathway
KORKOLA TERATOMA UP 16 11 All SZGR 2.0 genes in this pathway
korkola蛋黄囊肿瘤 20 14 All SZGR 2.0 genes in this pathway
Korkola Seminoma UP 44 27 All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER DN 481 290 All SZGR 2.0 genes in this pathway
Onken Uveal黑色素瘤 783 507 All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE UP 351 230 All SZGR 2.0 genes in this pathway
Chemnitz对前列腺素E2 DN的反应 391 222 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255 177 All SZGR 2.0 genes in this pathway
Timofeeva生长应力通过STAT1 DN 16 12 All SZGR 2.0 genes in this pathway
Rodrigues DCC目标DN 121 84 All SZGR 2.0 genes in this pathway
runx1 runx1t1融合单核细胞的TONKS目标 204 140 All SZGR 2.0 genes in this pathway
Senese HDAC1靶向 457 269 All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238 144 All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP 114 66 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
甲状腺癌的Rodrigues分化不佳的DN 805 505 All SZGR 2.0 genes in this pathway
hahtola兄弟姐妹Fungoides皮肤 177 113 All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 136 94 All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN 485 334 All SZGR 2.0 genes in this pathway
甲状腺癌 443 294 All SZGR 2.0 genes in this pathway
CAIRO PML TARGETS BOUND BY MYC UP 23 17 All SZGR 2.0 genes in this pathway
Baris甲状腺癌DN 59 45 All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS UP 33 20 All SZGR 2.0 genes in this pathway
Johansson神经胶质作用是PDGFB 58 44 All SZGR 2.0 genes in this pathway
McBryan Pubertal乳房5 6WK DN 137 97 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP 197 135 All SZGR 2.0 genes in this pathway
NUNODA RESPONSE TO DASATINIB IMATINIB UP 29 20 All SZGR 2.0 genes in this pathway
BAKER HEMATOPOIESIS STAT3 TARGETS 16 12 All SZGR 2.0 genes in this pathway
BAKER HEMATOPOESIS STAT5 TARGETS 7 7 All SZGR 2.0 genes in this pathway
铃木在口腔癌中放大 16 12 All SZGR 2.0 genes in this pathway
MATTIOLI MULTIPLE MYELOMA WITH 14Q32 TRANSLOCATIONS 36 25 All SZGR 2.0 genes in this pathway
FUNG IL2 SIGNALING 1 11 7 All SZGR 2.0 genes in this pathway
具有STAT5绑定位点的真菌IL2目标 7 5 All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向神经上皮 176 111 All SZGR 2.0 genes in this pathway
MURATA VIRULENCE OF H PILORI 24 16 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203 134 All SZGR 2.0 genes in this pathway
Spielman淋巴细胞欧洲vs亚洲 479 299 All SZGR 2.0 genes in this pathway
带有E盒的WEI MYCN目标 795 478 All SZGR 2.0 genes in this pathway
Guenther生长球形与粘附 21 15 All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283 177 All SZGR 2.0 genes in this pathway
Benporath MYC带Ebox的目标 230 156 All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 2 30 23 All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN 76 52 All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU UP 53 37 All SZGR 2.0 genes in this pathway
TCGA胶质母细胞瘤副本编号 75 36 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
Rozanov MMP14靶向 266 171 All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK 143 96 All SZGR 2.0 genes in this pathway
BYSTRYKH造血干细胞QTL顺式 128 77 All SZGR 2.0 genes in this pathway
CHESLER BRAIN QTL CIS 75 51 All SZGR 2.0 genes in this pathway
BYSTRYKH造血细胞和脑QTL顺式 65 38 All SZGR 2.0 genes in this pathway
tarte浆细胞与Plasmablast DN 309 206 All SZGR 2.0 genes in this pathway
Ferrando Lyl1邻居 15 12 All SZGR 2.0 genes in this pathway
Coller MYC的目标 25 19 All SZGR 2.0 genes in this pathway
Iizuka肝癌早期复发 11 10 All SZGR 2.0 genes in this pathway
Sansom APC目标 126 84 All SZGR 2.0 genes in this pathway
棕色髓样细胞的发育 165 100 All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318 215 All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163 115 All SZGR 2.0 genes in this pathway
Wang由Hoxa9和Meis1 Up永生 31 24 All SZGR 2.0 genes in this pathway
EWSR1 FLI1融合的Rorie目标 30 22 All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP 114 84 All SZGR 2.0 genes in this pathway
MLL CBP融合DN的王目标 45 31 All SZGR 2.0 genes in this pathway
Tavor Cebpa靶向 48 36 All SZGR 2.0 genes in this pathway
VERHAAK AML NPM1突变的DN 246 180 All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP 151 103 All SZGR 2.0 genes in this pathway
Sesto对UV C8的反应 72 56 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
CUI TCF21靶向 37 27 All SZGR 2.0 genes in this pathway
山崎TCEB3助教RGETS UP 175 116 All SZGR 2.0 genes in this pathway
Simbulan Parp1靶向 31 23 All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT 51 41 All SZGR 2.0 genes in this pathway
Gerhold脂肪形成DN 64 44 All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN 98 67 All SZGR 2.0 genes in this pathway
Kaab心脏中心与心室DN 261 183 All SZGR 2.0 genes in this pathway
HAN JNK SINGALING UP 35 21 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS PRENATAL 42 33 All SZGR 2.0 genes in this pathway
LIANG SILENCED BY METHYLATION UP 32 18 All SZGR 2.0 genes in this pathway
CUI TCF21目标2向上 428 266 All SZGR 2.0 genes in this pathway
伊万诺娃造血细胞和祖细胞 681 420 All SZGR 2.0 genes in this pathway
江缺氧正常 311 205 All SZGR 2.0 genes in this pathway
结肠癌中甲基化的甲基化 27 20 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS 212 121 All SZGR 2.0 genes in this pathway
Sansom Wnt途径需要MYC 58 43 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
马丁内斯RB1靶向 673 430 All SZGR 2.0 genes in this pathway
Martinez TP53靶向 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向DN 591 366 All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP 115 80 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430 288 All SZGR 2.0 genes in this pathway
HOQUE METHYLATED IN CANCER 56 45 All SZGR 2.0 genes in this pathway
Zheng胶质母细胞瘤可塑性 250 168 All SZGR 2.0 genes in this pathway
MATZUK EARLY ANTRAL FOLLICLE 13 11 All SZGR 2.0 genes in this pathway
mir15a和mir16 1的Bonci目标 91 75 All SZGR 2.0 genes in this pathway
ERBB2 CDC25A的射线肿瘤发生 104 57 All SZGR 2.0 genes in this pathway
lu肿瘤血管生成 25 22 All SZGR 2.0 genes in this pathway
格雷希克癌症复制号码 323 240 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C CLUSTER DN 32 21 All SZGR 2.0 genes in this pathway
Boylan多发性骨髓瘤C D DN 252 155 All SZGR 2.0 genes in this pathway
REICHERT G1S REGULATORS AS PI3K TARGETS 8 6 All SZGR 2.0 genes in this pathway
罗斯白血病与MLL融合 78 49 All SZGR 2.0 genes in this pathway
VANASSE BCL2靶向DN 74 50 All SZGR 2.0 genes in this pathway
霍夫FMANN PRE BI TO LARGE PRE BII LYMPHOCYTE DN 75 61 All SZGR 2.0 genes in this pathway
霍夫FMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP 70 49 All SZGR 2.0 genes in this pathway
霍夫曼不成熟到成熟的B淋巴细胞DN 50 36 All SZGR 2.0 genes in this pathway
张TLX目标36hr 221 150 All SZGR 2.0 genes in this pathway
Shedden肺癌良好生存A12 317 177 All SZGR 2.0 genes in this pathway
MIKKELSEN PLURIPOTENT STATE DN 8 7 All SZGR 2.0 genes in this pathway
Hsiao家政基因 389 245 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA 43 27 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS UP 74 45 All SZGR 2.0 genes in this pathway
米利假足 518 299 All SZGR 2.0 genes in this pathway
Liu Vav3前列腺致癌作用 89 61 All SZGR 2.0 genes in this pathway
Lee Liver Cancer Hepatoblast 16 12 All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP 105 75 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
LI PROSTATE CANCER EPIGENETIC 30 22 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA3 UP 80 54 All SZGR 2.0 genes in this pathway
Hoshida肝癌亚类S1 237 159 All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP 143 100 All SZGR 2.0 genes in this pathway
由MYC约束 1103 714 All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335 193 All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307 182 All SZGR 2.0 genes in this pathway
马滕斯三维诺蛋白响应DN 841 431 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3靶向 387 225 All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS 77 62 All SZGR 2.0 genes in this pathway
Wierenga Stat5A靶向 217 131 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到 1137 655 All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 2 UP 15 12 All SZGR 2.0 genes in this pathway
STAT3的Azare肿瘤转化 121 70 All SZGR 2.0 genes in this pathway
AZARE STAT3 TARGETS 24 12 All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向DN 553 343 All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP 116 87 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
YU BAP1目标 29 21 All SZGR 2.0 genes in this pathway
前列腺癌模型DN中的Acevedo FGFR1靶标 308 187 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway