Gene Page:KYNU

Summary?
GeneID 8942
Symbol KYNU
Synonyms KYNUU
Description kynureninase
Reference MIM:605197|HGNC:HGNC:6469|Ensembl:ENSG00000115919|HPRD:08940|Vega:OTTHUMG00000131829
Gene type protein-coding
地图上的位置 2q22.2
Pascal p-value 0.263
Fetal beta -0.327

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.023
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.02395
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PERP 0.60 0.56
LASS1 0.57 0.58
NOTCH4 0.55 0.57
TENC1 0.54 0.64
KCNJ14 0.54 0.51
SSH3 0.54 0.57
SPATA20 0.53 0.46
ZBTB7B 0.53 0.46
GPR4 0.53 0.44
ARSA 0.52 0.50
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RPL9 -0.38 -0.48
LYPLAL1 -0.37 -0.43
RWDD1 -0.37 -0.43
SUB1 -0.36 -0.39
RNASEH2B -0.35 -0.39
AC090186.1 -0.35 -0.36
DTWD1 -0.35 -0.41
PSMA6 -0.34 -0.42
VRK2 -0.34 -0.35
C11orf51 -0.34 -0.36

Section III. Gene Ontology annotation

Molecular function 去后m Evidence Neuro keywords PubMed ID
GO:0016787 hydrolase activity IEA -
GO:0042803 protein homodimerization activity IDA 11985583
GO:0030170 pyridoxal phosphate binding IEA -
GO:0030429 kynureninase activity EXP 9180257
GO:0030429 kynureninase activity IDA 9180257|11985583
GO:0030429 kynureninase activity IEA -
GO:0030429 kynureninase activity IMP 17334708
Biological process 去后m Evidence Neuro keywords PubMed ID
GO:0009435 NAD biosynthetic process IEA -
GO:0008152 metabolic process IEA -
GO:0006569 tryptophan catabolic process IEA -
GO:0006569 tryptophan catabolic process IMP 17334708
GO:0034341 response to interferon-gamma IDA 9291104
GO:0019805 quinolinate biosynthetic process IDA 9291104
GO:0034516 response to vitamin B6 IMP 1939450
GO:0043420 anthranilate metabolic process IDA 11985583
Cellular component 去后m Evidence Neuro keywords PubMed ID
GO:0005829 cytosol EXP 9180257
GO:0005829 cytosol IDA 6468727
GO:0005625 soluble fraction IDA 11985583
GO:0005737 cytoplasm IEA -
GO:0005739 mitochondrion IDA 6468727

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG TRYPTOPHAN METABOLISM 40 33 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200 136 All SZGR 2.0 genes in this pathway
REACTOME TRYPTOPHAN CATABOLISM 11 9 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408 247 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
NEWMAN ERCC6 TARGETS UP 26 18 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276 165 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 UP 139 83 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341 197 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP 457 269 All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238 144 All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP 114 66 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR DN 129 84 All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP 66 47 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 UP 64 46 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN 186 107 All SZGR 2.0 genes in this pathway
MAHADEVAN IMATINIB RESISTANCE UP 23 15 All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER DN 54 37 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330 217 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
LI CISPLATIN RESISTANCE UP 28 20 All SZGR 2.0 genes in this pathway
TSUNODA CISPLATIN RESISTANCE DN 51 38 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
WU CELL MIGRATION 184 114 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223 140 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE DN 66 43 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN 65 44 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 DN 64 38 All SZGR 2.0 genes in this pathway
FRASOR应对雌二醇DN 82 52 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309 206 All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS DN 87 69 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC DN 63 40 All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 DN 64 42 All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244 154 All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 128 90 All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION DN 184 132 All SZGR 2.0 genes in this pathway
SUZUKI RESPONSE TO TSA AND DECITABINE 1A 23 16 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK UP 244 151 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245 144 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP 123 75 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253 147 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282 183 All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN 154 101 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP 147 83 All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP 126 92 All SZGR 2.0 genes in this pathway
BERNARD PPAPDC1B TARGETS UP 40 20 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP 125 68 All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 67 52 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
TAVAZOIE METASTASIS 108 68 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 11 36 24 All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP 181 106 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 12HR DN 33 25 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP 76 46 All SZGR 2.0 genes in this pathway
KAMMINGA SENESCENCE 41 26 All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP 75 47 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222 147 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216 130 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR DN 91 56 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 116 74 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 DN 88 61 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL 160 106 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428 246 All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION UP 110 68 All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP 86 54 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 3 16 12 All SZGR 2.0 genes in this pathway