Gene Page:MGAM
Summary?
| GeneID | 8972 |
| Symbol | MGAM |
| Synonyms | MG|MGA |
| Description | maltase-glucoamylase |
| Reference | MIM:154360|HGNC:HGNC:7043|Ensembl:ENSG00000257335|HPRD:01104|Vega:OTTHUMG00000158395 |
| Gene type | protein-coding |
| Map location | 7q34 |
| Pascal p-value | 0.601 |
| Sherlock p-value | 0.632 |
| DMG | 1 (# studies) |
| eGene | Caudate basal ganglia Cortex Frontal Cortex BA9 Hypothalamus |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| PMID:cooccur | High-throughput literature-search | 系统搜索PubMed的共病的基因with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg26125550 | 7 | 141695623 | MGAM | 5.715E-4 | -0.522 | 0.049 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SMPD4 | 0.73 | 0.68 |
| CDAN1 | 0.72 | 0.67 |
| DVL2 | 0.72 | 0.68 |
| CAD | 0.72 | 0.68 |
| C17orf53 | 0.71 | 0.62 |
| NXF1 | 0.71 | 0.66 |
| LEMD2 | 0.71 | 0.67 |
| HAUS5 | 0.71 | 0.64 |
| CNTROB | 0.70 | 0.65 |
| UNK | 0.70 | 0.65 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C5orf53 | -0.53 | -0.58 |
| AF347015.31 | -0.50 | -0.59 |
| CXCL14 | -0.50 | -0.60 |
| MT-CO2 | -0.49 | -0.59 |
| IFI27 | -0.49 | -0.57 |
| AF347015.27 | -0.49 | -0.57 |
| AF347015.33 | -0.48 | -0.57 |
| FXYD1 | -0.47 | -0.56 |
| HIGD1B | -0.47 | -0.58 |
| CA4 | -0.47 | -0.51 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG GALACTOSE METABOLISM | 26 | 22 | All SZGR 2.0 genes in this pathway |
| KEGG STARCH AND SUCROSE METABOLISM | 52 | 33 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF CARBOHYDRATES | 247 | 154 | All SZGR 2.0 genes in this pathway |
| TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D DN | 143 | 83 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC2 TARGETS DN | 133 | 77 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS DN | 536 | 332 | All SZGR 2.0 genes in this pathway |
| KIM WT1 TARGETS DN | 459 | 276 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| JAERVINEN AMPLIFIED IN LARYNGEAL CANCER | 40 | 24 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER WITH H3K9ME3 UP | 141 | 75 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER RELAPSE IN BONE UP | 97 | 61 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA C D DN | 252 | 155 | All SZGR 2.0 genes in this pathway |
| CHYLA CBFA2T3 TARGETS UP | 387 | 225 | All SZGR 2.0 genes in this pathway |
| ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF | 516 | 308 | All SZGR 2.0 genes in this pathway |
| HECKER IFNB1 TARGETS | 95 | 54 | All SZGR 2.0 genes in this pathway |